Brain and Behavior in Early Iron Deficiency

早期缺铁时的大脑和行为

基本信息

批准号：
7389149
负责人：
BETSY LOZOFF
金额：
$ 21.45万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7389149
关键词：
Accounting Address Adolescent Adopted Adult Adverse effects Affect Affective Age Anemia Animal Model Animals Appendix Auditory Brainstem Responses Autopsy Basic Science Behavior Behavior assessment Behavioral Behavioral inhibition Biochemical Brain Brain Hypoxia-Ischemia Brain region Breast Feeding CNS processing California Caregivers Carrier Proteins Child Chile Chronic Classification Clinical Clinical Investigator Cocaine Code Cognition Cognitive Collaborations Compatible Complement Condition Conflict (Psychology)Corpus striatum structure Country Data Analyses Depth Developed Countries Developing Countries Development Diet Dietary Iron Diffuse Disadvantaged Disease Disruption Dopamine Educational process of instructing Effectiveness Electrophysiology (science)Emotional Employee Strikes Environment Equipment Event-Related Potentials Evoked Potentials Excision Experimental Designs Experimental Models Face Fetal Alcohol Exposure Financial compensation Follow-Up Studies Forelimb Fostering Funding Future Gene Proteins Genes Genomics Glutamates Glutamine Growth Head Hippocampus (Brain)Hour Human Hydrocortisone Impairment Impulsivity In Vivo NMR Spectroscopy Infant Injury Institutes Interdisciplinary Study Intervention Investigation Iron Iron deficiency anemia Iron-Regulatory Proteins Knowledge Laboratories Lactation Language Language Development Lead Learning Leukocytes Life Link Long-Term Effects Longitudinal Studies Masks Measures Mercury Metabolic Michigan Minnesota Minority Modeling Monkeys Mothers Motor Myelin NMR Spectroscopy Nature Neuroanatomy Neurosciences Neurotransmitters Newborn Infant Nurseries Nursery Schools Nutrient Oligodendroglia Outcome Paper Pathway interactions Pattern Pennsylvania Performance Perinatal Peripheral Pharmaceutical Preparations Play Population Positron-Emission Tomography Pregnancy Pregnant Women Prematurity of fetus Primates Problem behavior Process Program Research Project Grants Progress Reports Proteomics Puberty Publishing Purpose Rate Rattus Recording of previous events Recovery Reflex action Reporting Research Research Design Research Personnel Reversal Learning Rewards Risk Rodent Rodent Model Role School-Age Population Scientist Secondary to Sensorimotor functions Sensory Serotonin Severities Short-Term Memory Shyness Side Site Social Environment Social Interaction Staging Stress Structure Supplementation Syndrome System Techniques Testing Texas Time Training Universities Videotape Visual Acuity Weaning Wisconsin Withdrawal Woman Work animal data austin base behavior measurement brain behavior brain metabolism brain tissue concept day deprivation design distraction dopamine system executive function experience human study improved infancy infant animal infant of diabetic mother innovation interdisciplinary collaboration memory recognition monoamine morris water maze myelination neurotoxic neurotoxicity neurotransmission nonhuman primate noradrenaline transporter novel nutrition postnatal prenatal prevent programs pup relating to nervous system response sensorimotor system social social cognition stressor teenage mother trend vigilance young mother

项目摘要

The overall purposes of this program-project grant (PPG) are to understand how iron deficiency alters brain and behavior in early development and identify interventions that will correct or prevent ill effects in the shortand long-term. Up to 75% of women worldwide are anemic during pregnancy, with about half due to iron deficiency. In developing countries, 46-66% of children < 4 years are anemic, again with half attributed to iron deficiency, and iron deficiency disproportionately affects poor and/or minority mothers and infants everywhere. Yet there are still important unanswered questions about the brain and behavior effects of early iron deficiency. In the next 5 years, the PPG will focus on 1) timing of iron deficiency in relation to different stages of brain development, 2) timing of iron repletion to ameliorate short-term effects and prevent longterm consequences for brain and behavior, and 3) in-depth study of short- and long-term effects and the processes that account for them. PPG involves 4 projects (1 human infant, 2 monkey, 1 rodent) supported by 3 cores (administrative, analytical, and statistical).The component projects and cores, with interdisciplinary collaboration among leading clinical and basic science researchers, are tightly linked conceptually and methodologically, designed so that each has a special but complementary role. Project I (human infant) will be a systematic investigation of brain and behavior effects of pre- v. postnatal v. combined pre- and postnatal iron deficiency in human infants and the timing of iron treatment. Project II (Davis monkey) will use an experimental model to pursue its novel finding that prenatal iron deprivation produced a behavioral profile of reduced inhibition and increased impulsivity, despite iron repletion. Project III (Madison monkey) will assess brain-behavior effects of combined pre- and postnatal iron deficiency in infants born to young mothers - a naturalistic model directly relevant to vulnerable human populations (developing countries, adolescent mothers). Project IV (developing rodent) will focus on the effectiveness of iron therapy at different times in brain development in preventing genomic, biochemical, structural, and behavioral alterations in adulthood. It will also consider the potential for neurotoxicity with too much iron following early iron deficiency. With close integration, all projects assess neural and behavioral development. Each uses innovative approaches to assess the brain (e.g., electrophysiology in Project I, PET with drug challenge in Project II, brain tissue in Project III, and regional genomics in Project IV). Individually, each project represents a substantial leap beyond previous research on early iron deficiency. Collectively, the program will make major contributions to understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder.

该计划项目拨款 (PPG) 的总体目的是了解缺铁如何改变大脑和早期发育中的行为，并确定纠正或预防短期不良影响的干预措施长期。全球高达 75% 的女性在怀孕期间患有贫血，其中约一半是由铁引起的不足。在发展中国家，46-66% 的 4 岁以下儿童患有贫血，其中一半归因于贫血缺铁，缺铁对贫困和/或少数民族母亲和婴儿的影响尤为严重到处。然而，关于早期儿童对大脑和行为的影响，仍有一些重要的未解之谜。缺铁。在未来 5 年中，PPG 将重点关注 1) 与不同疾病相关的缺铁时机。大脑发育阶段，2) 补充铁的时机以改善短期影响并预防长期影响对大脑和行为的影响，以及3）深入研究短期和长期影响以及解释它们的过程。 PPG 涉及 4 个项目（1 个人类婴儿、2 个猴子、1 个啮齿动物），由 3个核心（管理、分析和统计）。组成项目和核心，具有跨学科性领先的临床和基础科学研究人员之间的合作，在概念和概念上紧密相连在方法论上，设计使每个人都具有特殊但互补的作用。项目 I（人类婴儿）将对产前、产后、结合产前和产后的大脑和行为影响进行系统的研究人类婴儿产后缺铁和铁治疗的时机。项目二（戴维斯猴）将使用一个实验模型来追求其新发现，即产前缺铁会产生行为特征尽管补充了铁，但抑制作用却减少了，冲动性增加了。项目 III（麦迪逊猴）将评估婴儿产前和产后缺铁对大脑行为的影响母亲——与弱势群体（发展中国家、青春期的母亲）。项目 IV（开发啮齿动物）将重点研究铁疗法在不同时期的有效性。大脑发育中预防基因组、生化、结构和行为改变的时间成年期。它还将考虑早期铁剂摄入过多后可能产生的神经毒性。不足。通过紧密结合，所有项目都评估神经和行为发展。各用评估大脑的创新方法（例如项目 I 中的电生理学、PET 与药物挑战）项目 II、项目 III 中的脑组织和项目 IV 中的区域基因组学）。每个项目单独与之前关于早期缺铁的研究相比，这是一个巨大的飞跃。总的来说，该计划将为理解、治疗和预防铁对大脑和行为的影响做出重大贡献缺乏症，世界上最常见的单一营养素紊乱。