Brain and Behavior in Early Iron Deficiency Administrative Core

早期缺铁的大脑和行为管理核心

基本信息

批准号：
7904279
负责人：
BETSY LOZOFF
金额：
$ 12.91万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7904279
关键词：
Accounting Address Adopted Affect Anemia Animal Model Basic Science Behavior Behavioral Biochemical Brain Brain Hypoxia-Ischemia CNS processing California Child Classification Clinical Clinical Investigator Cocaine Cognition Collaborations Conflict (Psychology)Corpus striatum structure Country Developed Countries Developing Countries Development Diffuse Disadvantaged Disease Effectiveness Electrophysiology (science)Employee Strikes Event-Related Potentials Experimental Models Fetal Alcohol Exposure Financial compensation Funding Genes Genomics Head Hippocampus (Brain)Human Impulsivity Infant Interdisciplinary Study Intervention Investigation Iron Knowledge Laboratories Lead Learning Link Long-Term Effects Measures Mercury Michigan Minnesota Minority Modeling Monkeys Mothers Nutrient Oligodendroglia Outcome Pennsylvania Perinatal Pharmaceutical Preparations Population Positron-Emission Tomography Pregnancy Pregnant Women Primates Process Program Research Project Grants Progress Reports Research Research Design Research Personnel Risk Rodent Rodent Model Role Scientist Staging Structure System Techniques Texas Time Universities Wisconsin Woman Work austin behavior measurement brain behavior brain tissue deprivation design high risk improved infancy infant of diabetic mother innovation interdisciplinary collaboration meetings monoamine myelination neurotoxic neurotoxicity neurotransmission novel postnatal premature prenatal prevent programs relating to nervous system response teenage mother trend young mother

项目摘要

The overall purposes of this program-project grant (PPG) are to understand how iron deficiency alters brain and behavior in early development and identify interventions that will correct or prevent ill effects in the shortand long-term. Up to 75% of women worldwide are anemic during pregnancy, with about half due to iron deficiency. In developing countries, 46-66% of children < 4 years are anemic, again with half attributed to iron deficiency, and iron deficiency disproportionately affects poor and/or minority mothers and infants everywhere. Yet there are still important unanswered questions about the brain and behavior effects of early iron deficiency. In the next 5 years, the PPG will focus on 1) timing of iron deficiency in relation to different stages of brain development, 2) timing of iron repletion to ameliorate short-term effects and prevent longterm consequences for brain and behavior, and 3) in-depth study of short- and long-term effects and the processes that account for them. PPG involves 4 projects (1 human infant, 2 monkey, 1 rodent) supported by 3 cores (administrative, analytical, and statistical).The component projects and cores, with interdisciplinary collaboration among leading clinical and basic science researchers, are tightly linked conceptually and methodologically, designed so that each has a special but complementary role. Project I (human infant) will be a systematic investigation of brain and behavior effects of pre- v. postnatal v. combined pre- and postnatal iron deficiency in human infants and the timing of iron treatment. Project II (Davis monkey) will use an experimental model to pursue its novel finding that prenatal iron deprivation produced a behavioral profile of reduced inhibition and increased impulsivity, despite iron repletion. Project III (Madison monkey) will assess brain-behavior effects of combined pre- and postnatal iron deficiency in infants born to young mothers - a naturalistic model directly relevant to vulnerable human populations (developing countries, adolescent mothers). Project IV (developing rodent) will focus on the effectiveness of iron therapy at different times in brain development in preventing genomic, biochemical, structural, and behavioral alterations in adulthood. It will also consider the potential for neurotoxicity with too much iron following early iron deficiency. With close integration, all projects assess neural and behavioral development. Each uses innovative approaches to assess the brain (e.g., electrophysiology in Project I, PET with drug challenge in Project II, brain tissue in Project III, and regional genomics in Project IV). Individually, each project represents a substantial leap beyond previous research on early iron deficiency. Collectively, the program will make major contributions to understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder.

该计划项目赠款（PPG）的总体目的是了解铁缺乏症如何改变大脑和早期发展中的行为，并确定将纠正或防止短暂影响不良影响的干预措施长期。在怀孕期间，全球多达75％的妇女是贫血的，大约一半是由于铁不足。在发展中国家中，有46％的儿童<4岁是贫血，又有一半归因于铁缺乏症和铁缺乏症会影响贫穷和/或少数族裔母亲和婴儿到处。然而，关于早期的大脑和行为影响仍然存在重要的问题铁缺乏。在接下来的5年中，PPG将重点关注1）相对于不同的铁缺乏时间大脑发育的阶段，2）铁的时机可以改善短期影响并防止长期对大脑和行为的影响，以及3）对短期和长期影响的深入研究处理它们的处理。 PPG涉及4个项目（1个人类婴儿，2只猴子，1个啮齿动物） 3个核心（行政，分析和统计）。组件项目和核心，具有跨学科领先的临床和基础科学研究人员之间的协作在概念上紧密相关，从方法上讲，设计使每个人都具有特殊但互补的作用。项目I（人类婴儿）将成为对大脑和行为影响的系统研究人类婴儿的产后铁缺乏症和铁治疗的时间。项目II（戴维斯猴子）将使用一种实验模型，以追求其新颖的发现，即产前铁剥夺产生了行为概况尽管是铁的抑制作用和冲动性的降低和增加的冲动性。 III项目（麦迪逊猴）将评估年轻人出生的婴儿前和产后缺铁的脑行为影响母亲 - 一种自然主义模式，与脆弱的人口直接相关（发展中国家，青春期母亲）。 IV项目（发展啮齿动物）将重点介绍不同的铁治疗的有效性在预防基因组，生化，结构和行为改变的大脑发展中的时代成年。早期铁后，它还将考虑使用过多铁的神经毒性的潜力不足。通过紧密整合，所有项目都评估了神经和行为发展。每种方法都使用创新的方法来评估大脑（例如，项目I中的电生理学，项目II中的药物挑战，项目III中的脑组织和项目IV中的区域基因组学）。单独地，每个项目都超出了对早期铁缺乏症的先前研究的重大飞跃。总的来说，该计划将对世界上最常见的单一营养障碍的铁缺乏症的理解，治疗和预防大脑和行为影响做出重大贡献。