Making connections among social ties, neural sensitivity to social signals, and outcomes

在社会关系、对社会信号的神经敏感性和结果之间建立联系

• 批准号: 10200497
• 负责人: PEARL H CHIU
• 金额: $ 64.71万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10200497
• 关键词: Address; Alcohol consumption; Alcoholism; Alcohols; Anxiety; Behavioral; Brain; COVID-19; Characteristics; Computer Models; Consumption; Enrollment; Equation; Human; Individual; Life; Link; Longitudinal cohort; Measures; Mechanics; Mediating; Mediation; Mental Depression; Mental Health; Modeling; Moods; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Persons; Play; Procedures; Process; Reporting; Request for Applications; Role; Sampling; Signal Transduction; Social Distance; Social Environment; Social Functioning; Social Interaction; Social isolation; Social outcome; Source; Statistical Models; Structure; Testing; Time; To specify; Trust; Visit; Work; addiction; base; behavioral economics; behavioral response; biopsychosocial; design; experience; indexing; interest; neurobiological mechanism; neuroimaging; physical conditioning; preference; recruit; relating to nervous system; response; satisfaction; social; social factors; social structure; tool

PROJECT SUMMARY Social isolation is associated with excessive alcohol use, depression, anxiety, and other poor outcomes (e.g., Daeppen et al., 2013; Moos et al., 2001; Muller et al., 2017; Zuckermann et al., 2020). Substantial variability also exists in these associations, such that individuals with limited social ties do experience positive outcomes and socially connected individuals similarly do experience negative outcomes (Bond et al., 2007; Bryan et al., 2017; Eddie & Kelly, 2017; Spohr et al., 2019). Despite the importance of social factors in alcohol use and related outcomes, the mechanisms via which social connectedness or isolation yield positive and negative outcomes remains largely unexplored, in part due to difficulties eliciting and quantifying interpersonal processes in a parametric manner. We have previously shown that sensitivity to social signals may be parameterized in the context of interactive behavioral economic games and provide powerful tools with which to examine sources of variability and potential mechanisms through which social preferences are related to mental health (Chung et al., 2015; Chiu et al., 2008; King-Casas et al., 2005, 2008; King-Casas & Chiu, 2012). Here, we use these tools to test the possibility that sensitivity to social signals in the context of social interaction influences how social ties yield variability in alcohol use, mood, and anxiety. To examine associations among social connectedness, sensitivity to social signals, and outcomes, we combine a longitudinal cohort design including time-lagged mediation analyses, functional neuroimaging, and a behavioral economic social exchange task. We will assess these associations (i) contemporaneously in Aim 1, (ii) over time in Aim 2, and (iii) following social restrictions related to COVID-19 in a large online sample in Aim 3. The broad hypothesis is that sensitivity to social signals (as measured by neurocomputational indices) will both moderate and mediate associations between social ties and alcohol use and related outcomes. The work is submitted in response to PAR-19-373 requesting applications addressing basic mechanisms of social connectedness, connection, and isolation, including those related to COVID-19. The application further is in line with specific interests of NIAAA and NIMH and in “mechanistic studies of the biopsychosocial causes and effects of social connection and isolation” and “behavioral [and] neurobiological mechanisms of social connection and isolation leading to alcohol use, addiction, or cessation of consumption.”

项目概要 社会孤立与过度饮酒、抑郁、焦虑和其他不良后果有关（例如， Daeppen 等人，2013；Moos 等人，2001；Muller 等人，2017；Zuckermann 等人，2020）。 存在于这些协会中，这样社会关系有限的个人确实会经历积极的结果， 具有社会联系的个人同样也会经历负面结果（Bond 等人，2007 年；Bryan 等人，2017 年； Eddie & Kelly，2017；Spohr 等人，2019）。 结果，社会联系或孤立产生积极和消极结果的机制 很大程度上仍未被探索，部分原因是难以引出和量化人际交往过程 我们之前已经表明，对社交信号的敏感性可以以参数化的方式进行。 互动行为经济游戏的背景，并提供强大的工具来检查来源 社会偏好与心理健康相关的变异性和潜在机制（Chung 等，2017） 等人，2015；Chiu 等人，2008；King-Casas 等人，2005，2008；King-Casas 和 Chiu，2012）。 测试社交互动背景下对社交信号的敏感性影响社交关系的可能性 酒精使用、情绪和焦虑的变化。 为了检查社会联系、对社会信号的敏感性和结果之间的关联，我们结合了 纵向队列设计，包括时滞中介分析、功能神经影像和行为 我们将在目标 1 中同时评估这些协会，(ii) 随着时间的推移 目标 2 中，以及 (iii) 目标 3 中的大型在线样本中遵循与 COVID-19 相关的社会限制。 假设是对社交信号的敏感性（通过神经计算指数测量）都会调节 并调解社会关系和饮酒及相关结果之间的关联。 响应 PAR-19-373 请求解决社会联系基本机制的应用程序， 连接和隔离，包括与 COVID-19 相关的应用程序进一步符合特定要求。 NIAAA 和 NIMH 的兴趣以及“社会生物心理社会原因和影响的机制研究” 连接和隔离”和“社会连接和隔离的行为[和]神经生物学机制 导致饮酒、成瘾或停止饮酒。”