Interactive effects of physical activity and neighborhood air pollution on risk of incident Alzheimer's disease and related dementias

体力活动和社区空气污染对阿尔茨海默病和相关痴呆症风险的交互影响

基本信息

批准号：
10193961
负责人：
Wei Xu
金额：
$ 18.75万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10193961
关键词：
Address Adult Affect Age Air Air Pollutants Air Pollution Alzheimer&apos s disease related dementia Behavioral Biological Blood Vessels Brain Cessation of life Characteristics Clinical Cognition Complex Confidence Intervals Data Data Set Databases Dementia Developed Countries Diagnosis Disease Education Elderly Environment Environmental Exposure Environmental Risk Factor Ethnic Origin Exercise Exposure to Formulation Frontotemporal Dementia Genotype Health Health behavior Heterogeneity Hospitalization Household Incidence Income Individual Knowledge Lead Light Link Literature Measurable Modeling Morbidity - disease rate Neighborhoods Neurons Nitrogen Dioxide Nitrogen Oxides Participant Particulate Matter Pathogenesis Physical activity Population Decreases Populations at Risk Prevention strategy Process Prospective Studies Public Health Recording of previous events Registries Relative Risks Research Research Design Risk Risk Factors Risk Reduction Sample Size Sampling Social Impacts Specificity Sports Structure Suggestion Testing Vascular Dementia Walking Woman aging population behavioral study biobank brain volume coarse particles cognitive benefits cognitive function cognitive reserve cost dementia risk disability economic impact fine particles follow-up hazard human old age (65+)interest men middle age modifiable risk mortality neurophysiology pleasure pollutant population based preservation prevent protective effect protective factors recruit sex social sociodemographics systematic review β-amyloid burden

项目摘要

Project summary Physical activity is an important protective factor against dementia, a condition increasingly affecting older adults worldwide. Currently, only 26% of men and 19% of women in the U.S. are sufficiently active. Public health initiatives aimed at encouraging physical activity have the potential of decreasing population-level dementia risk and related social costs. However, cumulating evidence is highly suggestive that exposure to high levels of air pollution is associated with a greater risk of dementia. Given these countervailing effects, the neuroprotective benefits induced by physical activity could be inhibited if people exercise in polluted air. The lack of knowledge on the interactive effects of physical activity and air pollution prevents the formulation of most effective dementia prevention strategies. This proposed study aims to determine if physical activity interacts with neighborhood air pollution to impact dementia risk. In addition, we will examine if certain types of air pollutants have a greater moderating effect on the relationship between certain types of physical activity and risk of dementia subtypes. This project will use a large, population-based dataset on adults ages between 40 and 69 years from UK Biobank to longitudinally examine the independent and interactive effects of physical activity and air pollution on incident dementia over ten years. The primary objective of this two year project is to test the central hypothesis that exposure to neighborhood air pollution inhibits the protective effects of physical activity on risk of incident dementia.

项目概要体力活动是预防痴呆症的重要保护因素，这种疾病对老年人的影响越来越大全世界的成年人。目前，美国只有 26% 的男性和 19% 的女性足够活跃。民众旨在鼓励身体活动的健康举措有可能减少人口数量痴呆症风险和相关的社会成本。然而，越来越多的证据强烈表明，暴露于空气污染严重与患痴呆症的风险增加有关。考虑到这些抵消效应，如果人们在污染的空气中锻炼，体力活动带来的神经保护作用可能会受到抑制。这由于缺乏对身体活动和空气污染的相互作用影响的了解，阻碍了制定最有效的痴呆症预防策略。这项拟议的研究旨在确定身体活动是否与附近空气污染相互作用，影响痴呆风险。此外，我们将检查某些类型的空气污染物对某些类型的身体活动之间的关系有更大的调节作用和痴呆亚型的风险。该项目将使用一个基于人口的大型数据集，涵盖年龄介于英国生物银行 40 和 69 年纵向研究了物理治疗的独立和交互影响十年来活动和空气污染对痴呆症事件的影响。这个为期两年的项目的主要目标是检验中心假设，即暴露于附近的空气污染会抑制身体的保护作用关于痴呆症风险的活动。