Prefrontal-amygdala interactions in social learning

社会学习中前额叶-杏仁核的相互作用

基本信息

批准号：
7618698
负责人：
PAUL J WHALEN
金额：
$ 32.38万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7618698
关键词：
Address Adolescent Affective Amygdaloid structure Animals Anterior Anxiety Anxiety Disorders Area Awareness Basic Science Brain Brain imaging Child Clinical Clinical Research Cognitive Collaborations Complex Cues Development Disease Dorsal Emotional Emotional disorder Event Exhibits Face Facial Expression Fright Functional Magnetic Resonance Imaging Funding Mechanisms Future General Hospitals Handedness Heart Human Individual Iris Knowledge Laboratories Lead Learning Literature Location Masks Massachusetts Nature Outcome Patients Pattern Plague Population Positioning Attribute Prefrontal Cortex Process Psychologist Psychopathology Research Role Sclera Social Conditions Social Environment Stimulus Structure Symptoms Translations Work classical conditioning depression design human subject improved neural circuit neuroimaging psychologic relating to nervous system research study response showing emotion social vigilance

项目摘要

DESCRIPTION (provided by applicant): This R01 application proposes to use functional neuroimaging with human subjects to elucidate the role of prefrontal-amygdala circuitry in the processing of facial expressions that predict different social outcomes. Presentations of facial expressions of emotion in neuroimaging studies have proven particularly robust stimuli for activating amygdala and prefrontal regions involved in processing biologically-relevant social cues. Further, these tasks have proven useful for revealing aberrant brain activation patterns in patients with various emotional disorders (e.g., anxiety, depression). Here we propose to further develop facial expression tasks for use with specific psychopathological disorders. The utility of this work is that it will provide for a better understanding of the basic rules that determine amygdala response (Aim 1), allow us to better understand how the amygdala interacts with reciprocally connected prefrontal areas when such expressions are encountered (Aim 2) and tie this social/emotional human work to the greater Pavlovian conditioning work, which shows particular promise for elucidating the neural substrates of fear learning and its aberrations in anxiety disorders (Aim 3). The experiments proposed here are critical for establishing an understanding of the normal pattern of human brain responsivity to important social cues in order to allow future developmental research (i.e., with children and adolescents) as well as direct translation to clinical populations. An area of the brain called the amygdala is particularly responsive to the facial expressions of others and has been shown to exhibit exaggerated reactivity to the facial expression of fear in subjects with anxiety disorders. This may, in part, underlie the symptoms of increased vigilance and hyper-reactivity to potential threat that plague individuals with anxiety disorders. The studies proposed here will further our understanding of these brain responses to facial expressions and offer improved human brain imaging tasks for future study of the brain responses that underlie anxiety disorders.

描述（由申请人提供）：此R01申请建议将功能神经影像与人类受试者使用功能性神经影像，以阐明前额叶 - 杏仁核电路在处理预测不同社会结果的面部表情中的作用。事实证明，在神经影像学研究中面部情绪表达的表现特别强大，以激活杏仁核和参与处理生物学上与生物学相关的社会提示的前额叶区域。此外，这些任务已被证明可用于揭示各种情绪障碍患者（例如焦虑症，抑郁症）的脑激活模式异常。在这里，我们建议进一步开发面部表达任务，以与特定的心理病理学疾病一起使用。这项工作的效用在于，它将更好地理解确定杏仁核反应的基本规则（AIM 1），使我们能够更好地了解杏仁核如何与遇到这种表达式相互联系的前额叶领域相互作用时，当遇到这种表达方式时，当遇到这种社交/情感的焦虑和恐惧的焦虑中，以使人们的焦虑症与越来越多的人相关，以使人们对众所周知的工作有所帮助，以使善良的工作有望，这是在越来越多的人，这是在越来越多的人，这是善于努力的工作，这是在越来越多的偏爱，这是在越来越多的偏爱，这是在越来越多的偏爱，这是在越来越多的偏爱，这是在越来越多的偏爱，这是在越来越多的偏爱，这是在越来越多的人。疾病（目标3）。此处提出的实验对于确定对重要社会提示的正常响应的正常模式至关重要，以便允许未来的发展研究（即与儿童和青少年）以及直接转化为临床人群。一个称为杏仁核的大脑区域对他人的面部表情特别敏感，并且已被证明对患有焦虑症的受试者的恐惧表达表现出夸张的反应性。这可能部分是在困扰着患有焦虑症的人的潜在威胁的警惕性和反应性高度反应的症状。这里提出的研究将进一步了解这些大脑对面部表情的反应，并提供改进的人脑成像任务，以对焦虑症的脑反应进行未来的研究。