Prefrontal-Amygdala Interactions in Social Learning

社会学习中的前额叶-杏仁核相互作用

基本信息

批准号：
9039660
负责人：
PAUL J WHALEN
金额：
$ 40.25万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9039660
关键词：
Adolescent Adult Affective Amygdaloid structure Anger Anxiety Anxiety Disorders Area Attention Back Behavioral Brain Child Clinical Cognitive Collaborations Complex Cues Data Development Diffuse Emotional Emotional disorder Empathy Face Facial Expression Failure Friends Fright Functional Magnetic Resonance Imaging Individual Individual Differences Laboratories Learning Longitudinal Studies Major Depressive Disorder Masks Measures Mental Depression Outcome Pathway interactions Patients Pattern Personality Persons Population Prefrontal Cortex Process Psychologist Publishing Regulation Reporting Research Rest Risk Factors Role Signal Transduction Social Behavior Stimulus Structure Symptoms System Techniques Time Translations Work attenuation base behavioral outcome behavioral response directed attention emotion regulation experience human subject neuroimaging novel psychologic relating to nervous system research study response showing emotion skills social social learning social situation white matter

项目摘要

DESCRIPTION (provided by applicant): This R01 application proposes functional neuroimaging studies with human subjects to elucidate the role of the prefrontal cortex and amygdala in the processing of facial identities and expressions that predict different social outcomes. Presentations of facial expressions of emotion in neuroimaging studies have proven particularly robust stimuli for activating amygdala and prefrontal regions involved in processing biologically- relevant social cues. Further, these tasks have proven useful for revealing aberrant brain activation patterns in patients with various emotional disorders (e.g., anxiety, depression). Here we propose to further develop our facial expression tasks to increase our understanding of cortical-subcortical interactions during the processing of these socially relevant cues. The utility of this work is that it will provide for a better understanding of the basic rules that determine amygdala responses, and allow us to better understand how the amygdala interacts with reciprocally connected prefrontal areas when such expressions are encountered. The proposed studies comprise programmatic extensions of our previous work as well as incorporate a novel longitudinal study of the effect of regulatory experience on brain structure. This specific study builds off our recent exciting published finding showing that the structural integrity of an amygdala-prefrontal pathway predicts individual differences in reported anxiety. The experiments proposed here are critical for establishing an understanding of the normal pattern of adult human brain responsivity to these ubiquitous social cues. These data will be usefully compared to complementary developmental research (i.e., with children and adolescents) and will be amenable to direct translation to clinical populations.

描述（由申请人提供）：此R01申请提出了对人类受试者的功能神经成像研究，以阐明前额叶皮层和杏仁核在处理面部身份和表达方面的作用，以预测不同的社会成果。事实证明，在神经影像学研究中面部情绪表达的表现特别强大，以激活杏仁核和参与处理生物学相关的社会提示的前额叶区域。此外，这些任务已被证明可用于揭示各种情绪障碍患者（例如焦虑症，抑郁症）的脑激活模式异常。在这里，我们建议进一步发展我们的面部表达任务，以增加对这些与社会相关的暗示处理过程中对皮质增生相互作用的理解。这项工作的实用性是，它将更好地理解确定杏仁核反应的基本规则，并让我们更好地理解杏仁核如何与遇到这种表达时相互连接的前额叶区域相互作用。拟议的研究包括我们先前工作的程序扩展，并结合了对调节经验对脑结构的影响的新纵向研究。这项特定的研究基于我们最近令人兴奋的发现，表明杏仁核前额途径的结构完整性预测了所报告焦虑的个体差异。这里提出的实验对于确定对这些无处不在的社会提示的正常方式的正常模式至关重要。这些数据将与互补的发展研究（即与儿童和青少年）相比，并且可以直接转化为临床人群。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The shape of faces (to come).

面孔的形状（即将到来）。

DOI：
10.1038/nn0708-739
发表时间：
2008
期刊：
Nature neuroscience
影响因子：
25
作者：
Whalen,PaulJ;Kleck,RobertE
通讯作者：
Kleck,RobertE

The Inverse Relationship between the Microstructural Variability of Amygdala-Prefrontal Pathways and Trait Anxiety Is Moderated by Sex.

DOI：
10.3389/fnsys.2016.00093
发表时间：
2016
期刊：
Frontiers in systems neuroscience
影响因子：
3
作者：
Kim MJ;Brown AC;Mattek AM;Chavez SJ;Taylor JM;Palmer AL;Wu YC;Whalen PJ
通讯作者：
Whalen PJ

The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety.

DOI：
10.1523/jneurosci.2335-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Kim MJ;Whalen PJ
通讯作者：
Whalen PJ

Preliminary report on the association between pulvinar volume and the ability to detect backward-masked facial features.