Integrative Health Sciences

综合健康科学

• 批准号: 7434800
• 负责人: John D Groopman
• 金额: $ 68.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434800
• 关键词: Address; Basic Science; Biological Markers; Certification; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Communities; Community Outreach; Complex; Core Facility; Development; Discipline; Disease; Early Diagnosis; Education and Outreach; Environmental Health; Epidemiology; Ethics; Faculty; Fostering; Goals; Health Sciences; Health Services Accessibility; Human Subject Research; Intervention; Intervention Studies; Investigation; Population; Prevention intervention; Preventive Intervention; Public Health; Public Health Applications Research; Public Health Schools; Purpose; Research; Research Infrastructure; Research Personnel; Schools; Services; Speed; Structure; Support of Research; Technology; Training; Translational Research; Translations; base; burden of illness; design; disorder risk; human subject; improved; instrumentation; interdisciplinary approach; member; research and development

A2. Purpose, Rationale and Objectives The purpose of the Integrated Health Sciences Facility Core (IHSFC) is to facilitate and enhance the speed at which translation of basic research discovery occurs into clinical or public health applications by members of the Johns Hopkins NIEHS Center in Urban Environmental Health. The rationale for incorporating and enhancing the functions of several of our existing facility cores into this new structure is built upon the recognition that addressing the problems of urban environmental health requires multidisciplinary approaches and ever increasing complex technologies. Our past facility core structure often had the unintended consequence of "stove piping" services. Since we are striving to facilitate the tackling of problems across disciplines, we have designed the IHSFC to streamline the ability of Center investigators to do translational research by creating a "one-stop" core that encompasses the services, instrumentation and seed-money necessary to promote linkages to public health. We feel that the IHSFC has taken what we have done well in the past in several facility cores and enhanced these services in a new format that will serve the Center during the next renewal cycle. The specific objectives of this core are: ¿ To provide services and access to instrumentation and technologies that foster integration of basic science into public health research, including epidemiology, prevention and intervention studies. ¿ To support research to improve exposure characterization, early detection of disease risk, biomarker discovery and development of preventive interventions for environmentally related diseases. ¿ To enhance partnerships between researchers and the community that impact on conduct of clinical and public health research through the linkage of the IHSFC with the Community Outreach and Education Core (COEC) in this Center. Translational research always encompasses population or clinical-based investigations that involve human subjects with the goal of reducing disease burden. Irrespective of whether these studies involve etiologic or active interventions, all of these investigations must undergo extensive human subjects review by the Public Health Institutional Review, Submission and Tracking (PHIRST) committee at the Johns Hopkins Bloomberg School of Public Health (http://phirst.jhsph.edu/). All faculty are required to take online training certification about the ethics of human subjects research (at www.citiprogram.org). Furthermore, investigators involved in clinical trials are strongly encouraged to avail themselves of the Center for Clinical Trials (http://cct.jhsph.edu) in the School to provide guidance for ethical research, and the development of data safety and monitoring boards. Thus, the extensive institutional commitment and infrastructure for human subject's research at this School obviates the need for the IHSFC to duplicate these activities.

A2。目的，理由和目标 综合健康科学设施核心（IHSFC）的目的是促进和增强 基础研究发现翻译到临床或公共卫生应用中的速度 约翰·霍普金斯（John Hopkins Niehs）的城市环境健康中心的成员。编码的理由 并将我们现有的几个设施核心的功能纳入这种新结构的构建是建立在此新结构上的 认识到解决城市环境健康问题需要多学科方法 并不断提高复杂技术。我们过去的设施核心结构通常是意外的 “炉子管道”服务的结果。由于我们正在努力促进解决问题 学科，我们设计了IHSFC来简化中心研究人员进行翻译的能力 通过创建一个涵盖服务，仪器和种子货币的“一站式”核心来研究 促进与公共卫生联系的必要条件。我们觉得IHSFC采取了我们所做的一切 过去的几个设施核心，并以新的格式增强了这些服务 下一个更新周期。 该核心的具体目标是： �提供促进基础科学整合的仪器和技术的服务和访问 进入公共卫生研究，包括流行病学，预防和干预研究。 �支持研究以提高暴露表征，早期发现疾病风险，生物标志物 针对环境疾病的预防干预措施的发现和开发。 �为了增强研究人员与社区之间的伙伴关系，以影响临床行为和 通过IHSFC与社区外展和教育核心的联系，公共卫生研究 （COEC）在这个中心。 翻译研究始终涵盖涉及人类的人群或基于临床的调查 受试者的目标是减少疾病伯恩。无论这些研究是否涉及病因或 积极的干预措施，所有这些调查都必须接受公众的广泛人类主题审查 卫生机构审查，提交和跟踪（PHIRST）委员会在约翰·霍普金斯·彭博 公共卫生学院（http://phirst.jhsph.edu/）。所有教师都必须接受在线培训认证 关于人类受试者研究的伦理（在www.citiprogram.org上）。此外，参与的调查人员 强烈鼓励临床试验临床试验中心（http://cct.jhsph.edu）。 在学校为道德研究提供指导，以及数据安全和监测的发展 董事会。这是针对人类受试者研究的广泛的机构承诺和基础设施 学校消除了IHSFC复制这些活动的必要性。