Detoxication of Air Pollutants in Humans with a Broccoli Supplement

西兰花补充剂对人体空气污染物的解毒

基本信息

批准号：
8885232
负责人：
John D Groopman
金额：
$ 43.74万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8885232
关键词：
Acetylcysteine Acrolein Aflatoxins Agriculture Air Air Pollutants Air Pollution Archives Area Asians Attention Automobiles Benzene Beverages Bioavailable Biological Markers Broccoli - dietary Burn injury Carcinogens Cereals Chemicals Chemoprevention Chemopreventive Agent China Chronic Disease Clinical Clinical Trials Cooking Practices Data Diet Dose Drops Drug Formulations Drug Kinetics Economic Development Economics Environmental Exposure Environmental Protection Excretory function Exposure to Female Food Gene Targeting Glucosinolates Glutathione S-Transferase Government Health Human Incidence Individual Ingestion International Agency for Research on Cancer Intervention Investigation Investments Longevity Lymphocyte Maize Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of lung Measures Myrosinase Participant Pattern Pharmacodynamics Policies Pollution Population Populations at Risk Power Plants Prevention strategy Preventive Intervention Primary Prevention Randomized Clinical Trials Rice Risk Rivers Rural Sampling Schedule Serum Signal Pathway Source Sulforaphane Time Toxic Environmental Substances Toxicant exposure Translations United States Urine Woman base cancer risk cohort design detoxication dietary supplements effective intervention glucoraphanin hazard mortality neoplasm registry non-smoking novel phenanthrene pollutant population based pre-clinical prospective public health relevance toxicant urinary

项目摘要

DESCRIPTION (provided by applicant): Air pollution has recently been declared a Group 1 human carcinogen by IARC. It is well documented that exposures are very high in Asian megacities including those in China. Our studies in the Yangtze River Basin region (Qidong) have revealed high internal dose levels of a spectrum of airborne toxicants, presumably reflecting the surge in economic development without concomitant attention to regional environmental protection. Reductions in exposures to airborne toxicants require substantive economic and political investments, driven by national and global mandates, which have proven difficult to implement. However, chemoprevention, especially food-based "green" chemoprevention, offers the opportunity for individuals to mitigate risks associated with these unavoidable exposures. Based upon our previous clinical trials demonstrating that broccoli sprout extracts (rich in the chemopreventive agent sulforaphane and its precursor glucoraphanin) enhanced the detoxication of multiple airborne toxicants from ambient exposures, we will examine a new dietary supplement that provides a consistent, bioavailable source of sulforaphane in the body using a clever, inexpensive formulation. It is our hypothesis that the extent of modulation of these hazard biomarker levels (e.g., mercapturic acids of volatile organic air pollutants) can predict the efficacy of chemopreventive interventions in at-risk populations and will guide their optimization and translation to practice. The specific aims of thi project are designed to understand, in detail, past and emerging patterns of exposure to airborne toxicants. To achieve the aims, we will use longitudinal samples over a 20- year period from our earlier studies in Qidong, China to quantify the extent of changes occurring in levels of air toxicants. These patterns will be evaluated in the context of recent, rapidly increasing risk o lung cancer in non-smoking women in Qidong. We will also optimize dose and schedule for a mechanism-based chemoprevention intervention with a broccoli-derived dietary supplement for enhanced detoxication of these chemical airborne hazards. We seek to provide frugal approaches to mitigate the actions of environmental toxins where legislative or regulatory approaches are not feasible at present.

描述（由适用提供）：IARC最近宣布了空气污染为1组人类致癌物。有充分的文献证明，包括中国在内的亚洲大城市的暴露量很高。我们在长江盆地地区（Qidong）的研究表明，机载有毒物质的内部剂量水平很高，大概反映了经济发展的激增，而没有同时关注区域环境保护。在国家和全球授权的推动下，对空中有毒物质的暴露量减少需要实质性的经济和政治投资，事实证明这很难实施。但是，化学预防，尤其是基于食品的“绿色”化学预防，为个人提供了减轻与这些不可避免的暴露有关的风险的机会。基于我们以前的临床试验，表明西兰花发芽提取物（富含化学预防剂磺胺硫烷及其前体葡萄糖磷酸）增强了从环境暴露中的多种空气中有毒物质的解毒，我们将研究一种新的饮食补充剂，可提供一种一致的，可提供一致的，具有硫磺素的源形式，它具有一种聪明的，具有聪明的，聪明的。我们的假设是，这些危害生物标志物水平的调节程度（例如，挥发性的苏联酸有机空气污染物）可以预测高危人群中化学预防干预措施的效率，并将指导其优化和转化为实践。 THI项目的具体目的旨在详细地理解对空中有毒物质的过去和新兴模式。为了实现目标，我们将在较早的中国Qidong研究中使用20年的纵向样本来量化空气有毒物质水平发生变化的程度。这些模式将在Qidong的非吸烟妇女中最近迅速增加的肺癌风险迅速增加的背景下进行评估。我们还将通过基于机制的化学预防干预措施优化剂量和时间表，并使用支链球衍生的饮食补充剂来增强这些化学空气传播危害的排毒。我们试图提供节俭的方法来减轻目前不可行的立法或监管方法的环境毒素的行动。