Assessment of the Neurological Impact of HIV-2 in West Africa

西非 HIV-2 神经系统影响评估

• 批准号: 7600390
• 负责人: DAVID B CLIFFORD
• 金额: $ 12.43万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-03 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600390
• 关键词: Affect; Africa; African; Aging; Characteristics; Clinical; Clinical Trials; Cohort Studies; Communities; Complication; Future; Gambia; Grant; HIV; HIV Infections; HIV-1; HIV-2; Impairment; Infection; International; Investigation; Laboratories; Medical Research; NIH Program Announcements; Nervous System Physiology; Neurocognitive; Neurologic; Neurologic Manifestations; Opportunistic Infections; Patients; Peripheral Nervous System Diseases; Preparation; Prevalence; Prevalence Study; Procedures; Research; Research Personnel; Research Project Grants; Sampling; Senegal; Site; Spinal Cord Diseases; Training; Universities; Washington; cohort; data sharing; design; neuroimaging; public health relevance; tool

DESCRIPTION (provided by applicant): Assessment of Neurological Impact of HIV-2 in West Africa This project is designed to develop capacity for clinical neurological assessment of human immunodeficiency virus induced neurological complications in West Africa, enhancing and sharing expertise of investigators at Washington University in St. Louis and other US centers with the Medical Research Council Laboratories in The Gambia and the Universite Cheikh Anta Diop of Dakar (Senegal). The project will develop clinical tools for description of neurological function relevant to HIV-1 and HIV-2 infection and train teams at African sites to reliably apply the tool to established cohorts of HIV-2 patients and controls. The project will characterize the prevalence and characteristics of neurocognitive impairment, peripheral neuropathy and myelopathy in HIV-2 subjects. Through the project the capacity to perform neurological assessments will be enhanced and teams will be established for future investigations. The project will also establish data sharing procedures for multicenter neuroclinical trials in West Africa. Pilot observations of neuroimaging and CSF characteristics of HIV-2 infected subjects, observations relevant to aging with HIV-2 infection, and description of the neurological opportunistic infections associated with HIV-2 will be provided to enhance future research projects. The project is designed to develop the capacity to undertake more detailed and mechanistic studies of neurological manifestations of HIV in West Africa in subsequent research applications. PUBLIC HEALTH RELEVANCE: Neurological impact of HIV infection is extremely common and is seriously disabling. HIV-2 is likely to also have significant neurological complications, yet has not been systematically studied. HIV-2 is prevalent in West Africa, and thus uniquely problematic for this region. Local expertise to study neurological complications is presently lacking, making this grant timely in providing an opportunity to develop the capacity to probe this complication by developing expertise for application in already established cohort studies. The project is responsive to needs of the communities suffering with HIV and is responsive to the program announcement seeking capacity building international projects.

描述（由申请人提供）：对HIV-2在西非的神经系统影响的评估该项目旨在为人类免疫缺陷病毒诱发的临床神经学评估能力评估西非的神经系统并发症，增强和共享圣路易斯大学华盛顿大学和其他美国中心研究人员的研究专业知识，并在医学研究委员会的实验室中与医学研究委员会的实验室中的医学研究委员会（Gambia and dii di a）ceikik and di a at a an a an a a an a anar di。该项目将开发临床工具，以描述与HIV-1和HIV-2感染相关的神经功能，并在非洲部位训练小组，以可靠地将工具应用于已建立的HIV-2患者和对照组的同类。该项目将表征HIV-2受试者中神经认知障碍，周围神经病和骨髓病的患病率和特征。通过该项目，将提高进行神经系统评估的能力，并建立团队以供未来的调查。该项目还将为西非的多中心神经临床试验建立数据共享程序。对HIV-2感染受试者的神经影像学和CSF特征的试验观察，与HIV-2感染相关的观察结果以及对与HIV-2相关的神经机会感染的描述，以增强未来的研究项目。该项目旨在发展在随后的研究应用中对西非艾滋病毒神经表现的更详细和机械研究的能力。 公共卫生相关性：艾滋病毒感染的神经系统影响非常普遍，并且正在严重致残。 HIV-2可能也有明显的神经系统并发症，但尚未系统地研究。 HIV-2在西非普遍存在，因此对于该地区而言是唯一的问题。目前缺乏研究神经系统并发症的本地专业知识，这使得这笔赠款及时提供了一个机会，可以通过在已经建立的队列研究中开发应用专业知识来开发这种并发症的能力。该项目对患有艾滋病毒的社区的需求有反应，并且对寻求能力建设国际项目的计划公告有回应。

项目成果

Neurologic manifestations of human immunodeficiency virus-2: dementia, myelopathy, and neuropathy in West Africa.

• DOI: 10.1007/s13365-011-0022-9
• 发表时间: 2011-04
• 期刊: JOURNAL OF NEUROVIROLOGY
• 影响因子: 3.2
• 作者: Choi, Youngjee;Townend, John;Vincent, Tim;Zaidi, Irfan;Sarge-Njie, Ramu;Jaye, Assan;Clifford, David B.
• 通讯作者: Clifford, David B.