WASHINGTON UNIVERSITY AIDS CLINICAL TRIALS UNIT

华盛顿大学艾滋病临床试验中心

• 批准号: 8402793
• 负责人: DAVID B CLIFFORD
• 金额: $ 141.56万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8402793
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Affect; Area; Cardiovascular system; Childhood; Clinical; Clinical Management; Clinical Research; Clinical Trials Unit; Communities; Comorbidity; Counseling; Country; Development; Disease; Enrollment; Funding; HIV; HIV Infections; HIV therapy; Head; Health; Hepatitis; Infection prevention; International; Leadership; Metabolic; Neurologic; Participant; Persons; Population; Prevention; Protocols documentation; Recruitment Activity; Research; Structure; System; Time; Translational Research; Translations; Universities; Vaccine Research; Vertical Disease Transmission; Washington; Work; clinical research site; drug development; improved; medical schools; outreach; screening; vaccine development

DESCRIPTION (provided by applicant): This application will continue the contributions of an existing AIDS Clinical Trails Unit at Washington University School of Medicine in St. Louis for the next seven years. We propose a Clinical Trial Unit with an administrative structure led by Dr. David Clifford facilitating active contribution to the AIDS Clinical Trials Group (ACTG) network (100%) proposed in an application responding to RFA AI-05-001 headed by Dr. Constance Benson. We will conduct clinical research by recruiting, screening, and enrolling research participants in trials responding to clinical research plans in the following areas: (1) Translational Research/Drug Development, (-25) (2) Optimization of Clinical Management, Including Co-Morbidities,(~55%) (2)Prevention of Mother-to-Child Transmission(~10%) (4) Vaccine Research and Development. (~5%) and (5) Prevention of Infection (5%). This application describes a single Clinical Research Site (CRS) at Washington University School of Medicine that will carry out all portions of this research agenda. The CRS application includes plans for recruiting, screening, and enrolling 20 subjects in typical protocols in the above research areas, as well as ongoing work supporting continuing trials organized by the ACTG system with in excess of100 participating subjects at the present time. The St. Louis CTU will also contribute to scientific leadership assisting development of translational research with particular emphasis on the co-morbidities including neurologic conditions, hepatitis, cardiovascular and metabolic complications. Additional scientific leadership and expertise will continue to be developed in areas of new HIV therapies and pediatric and adolescent manifestations of HIV disease. Ongoing support for a vital Community Advisory Board will be continued under this application, assuring the constructive engagement for advise and counsel from affected populations, as well as providing outreach and educational support to affected populations. Funding this application will provide for ongoing contributions of the Washington University AIDS research community in translation of critical scientific concepts to optimal implementation to the benefit of all persons with HIV infection. We anticipate improvements in therapy that will improve the health in our own community, country, and in the much larger international community affected by HIV/AIDS. ADMINISTRATIVE COMPONENT:

描述（由申请人提供）：本申请将在接下来的七年中继续在圣路易斯华盛顿大学医学院现有的艾滋病临床步道部门的贡献。我们提出了一个由戴维·克利福德（David Clifford）博士领导的行政结构的临床试验部门，促进了对AIDS临床试验小组（ACTG）网络（100％）的积极贡献，该申请应响应由Constance Benson博士领导的RFA AI-05-001。我们将通过招募，筛查和招募研究参与者参加以下领域响应临床研究计划的试验：（1）转化研究/药物开发，（-25）（2）临床管理的优化，包括临床管理，包括共培训，（约55％）（约55％）（约55％）（约55％）预防母亲传播（〜10％）（〜10％）（〜10％）（4）流动研究和发展。 （〜5％）和（5）预防感染（5％）。该申请描述了华盛顿大学医学院的一个临床研究站点（CRS），该地点将执行本研究议程的所有部分。 CRS申请包括招聘，筛查和招募20个受试者在上述研究领域的典型协议中的计划，以及正在进行的工作，支持ACTG系统组织的持续试验，目前有超过100名参与受试者。圣路易斯CTU还将为科学领导力做出贡献，协助转化研究的发展，特别着重于神经系统疾病，肝炎，心血管和代谢并发症等合并症。在新的艾滋病毒疗法以及艾滋病毒疾病的儿科和青少年表现的领域，将继续开发更多的科学领导力和专业知识。在本申请中将继续对重要的社区顾问委员会的持续支持，确保受影响人群的咨询和律师的建设性参与，并向受影响的人群提供外展和教育支持。资助此应用程序将为华盛顿大学艾滋病研究界的持续贡献，以翻译批判性科学概念，以最佳实施，以使所有艾滋病毒感染者受益。我们预计治疗方面会有所改善，这将改善我们自己的社区，国家以及受艾滋病毒/艾滋病影响的更大的国际社会的健康状况。 管理组件：