Washington University Network of Excellence in Neuroscience Clinical Trials Site

华盛顿大学神经科学临床试验卓越网络网站

• 批准号: 8241279
• 负责人: DAVID B CLIFFORD
• 金额: $ 30.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8241279
• 关键词: Adult; Child; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Data Coordinating Center; Discipline; Funding; Institutes; Leadership; Monitor; Neurologic; Neurology; Neurosciences; Performance; Population; Productivity; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Seasons; Site; Stroke; Training; Translational Research; United States National Institutes of Health; Universities; Washington; design; experience; nervous system disorder; outreach; programs; response; translational neuroscience

DESCRIPTION (provided by applicant): In response to RFA-NS-11-008 we propose to establish a clinical trial site at Washington University in St. Louis (WUSTL) as a part of the "Network of Excellence in Neuroscience Clinical Trials" (NEXT) program proposed by the National Institute of Neurological Diseases and Stroke (NINDS). Under the leadership of David B Clifford, MD (PI/PD) for the WUSTL site, with the large clinical and research programs at WUSTL in neurological disorders led by experts in most disciplines of pediatric and adult neurology, and with well -developed research infrastructure including our Neurologic Clinical Research Unit (NCRU) and experience in clinical trials we will provide a highly productive and efficient contributor to the NEXT group. Specific aims for this proposal are to: 1. Establish leadership for a Clinical Trials Site optimizing the ability of Washington University in St. Louis o be an effective contributing part of the Network for Excellence in Neuroscience Clinical Trials (NEXT) 2. Establish a plan for collaboration with the Clinical Coordinating Center (CCC), the Data Coordinating Center (DCC), and the potential co-investigators from Washington University in St. Louis to enhance productivity of the entire network, and specifically the WUSTL contributions to it 3. Establish a plan to facilitate recruitment and outreach supporting the conduct of NEXT trials that may include studies of uncommon neurological conditions 4. Establish a plan to leverage and support local clinical research resources particularly focusing on the NIH funded Institute of Clinical and Translational Sciences (ICTS) at Washington University and the Neuroclinical Research Unit (NCRU) 5. Establish means to optimize the efficiency of clinical research carried out at our site 6. Establish plan for performance monitorin to enhance the productivity of the WUSTL NEXT site 7. Establish plans to facilitate recruiting and training new professionals to contribute to the translational neuroscience programs at WUSTL and nationally PUBLIC HEALTH RELEVANCE: Emerging neuroscientific findings provide opportunities for new treatments for neurological disorders. Developing a highly efficient clinical trial network wil maximize the ability to study diverse neurological conditions. Effective sites will, like WUSTL, combine access to both children and adults, serve large clinical populations with diverse neurological disorders, include seasoned specialized investigators and establish efficient mechanisms to design and carry out high quality clinical trials.

描述（由申请人提供）：为了回应RFA-NS-11-008，我们建议在圣路易斯的华盛顿大学（WUSTL）建立一个临床试验地点，作为“神经科学临床试验卓越网络”的一部分（下一项）计划，该计划由国家神经疾病和Stroke和Stroke和Stroke（Ninds）提出的计划。在Wustl网站的MD（PI/PD）的领导下，WUSTL的大型临床和研究计划是由小儿和成人神经病学专家领导的神经系统疾病领域的大型临床和研究计划，并在包括我们的神经临床研究单元（NCRU）和临床方面的经验以及我们在临床方面的经验以及我们在临床方面的经验以及我们将在临床方面的经验，并提供了良好的研究基础结构。该提案的具体目的是：1。建立领导地位，以优化华盛顿大学在圣路易斯o的能力，成为神经科学临床试验卓越网络的有效贡献（下一个）2。建立与临床协调中心（CCC）的合作计划（CCC），以及在数据协调中心（dcc），以及整个数据协调中心（DCC），以及整个套件的工作范围，以及整个套件的工作。网络，特别是WUSTL对其的贡献。在我们的网站6上进行的临床研究。建立绩效监控计划，以提高wustl下一个网站7的生产率。建立计划，以促进招募和培训新专业人员，以为WUSTL和全国性的转化神经科学计划做出贡献 公共卫生相关性：新兴的神经科学发现为神经系统疾病的新疗法提供了机会。 开发高效的临床试验网络将最大程度地研究多种神经系统疾病的能力。有效的站点将像Wustl一样，将与儿童和成人的访问权限结合在一起，为具有不同神经系统疾病的大量临床人群提供服务，包括经验丰富的专业研究人员，并建立了有效的机制来设计和进行高质量的临床试验。