Genomics Core

基因组学核心

基本信息

批准号：
9978085
负责人：
J Michael Salbaum
金额：
$ 18.21万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9978085
关键词：
Anatomy Applications Grants Basic Science Bioinformatics Biological Biomedical Research Categories Cellular biology Centers of Research Excellence ChIP-seq Clinical Clinical Research Collaborations Communities Complex Computer software Counseling Custom Data Data Analyses Data Analytics Data Set Diabetes Mellitus Environment Equipment Excision Experimental Designs Extramural Activities Funding Gene Expression Gene Expression Profiling Generations Genetic Models Genomic approach Genomics Histologic Incidence Individual Knowledge Laboratories Louisiana Measurement Mentors Metabolic syndrome Methods Modernization Molecular Non-Insulin-Dependent Diabetes Mellitus Nucleic Acids Obesity Overweight Pathology Population Preparation Procedures Productivity Public Health Publications Quality Control Research Research Activity Research Personnel Research Project Grants Resources Robotics Sampling Services Source Systems Biology Techniques Technology Transgenic Organisms Translational Research base bioimaging cost effective epigenome epigenomics experimental study falls functional genomics genetic analysis genome-wide genomic data interest laser capture microdissection next generation next generation sequencing programs synergism tool

项目摘要

Nearly two-thirds of the US population is either clinically overweight or obese, and almost 10% of the population has adult-onset diabetes. Louisiana is afflicted with even higher incidence, a fact that provides the public health urgency for obesity and diabetes research conducted under the auspices of the Center of Biomedical Research Excellence at the Pennington Biomedical Research Center. Both basic and clinical research in obesity, diabetes, or metabolic syndrome requires genomics approaches to understand the molecular mechanisms that underlie the respective pathology. The Genomics Core of the PBRC COBRE seeks to facilitate such inquiries by providing access to modern genomics technologies that are typically too expensive for most individual laboratories to procure or to maintain. Based on the scientific requirements of COBRE and PBRC investigators, the Core has focused on `Functional Genomics', with measurements of gene expression and epigenomics approaches at center stage. The Specific Aims of the Core are (1) to make high quality and cost-effective genomics technology available to investigators, (2) to provide the bioinformatics necessary for the analytical and interpretative framework for genomics experiments, and (3) to serve as an intellectual and advisory resource and promote interactions and collaborations among investigators interested in genomics approaches. Based on a strong record of productivity in the prior two funding periods of the PBRC COBRE, the impact of the Genomics Core results from the facilitation of research progress, the removal of critical barriers, specifically in the realm of bioinformatics, and the creation of scientific synergy through interactions with the Cell Biology and Bioimaging Core, the Transgenic Core, and PBRC and COBRE investigators. Thus, the Genomics Core is a critical component to sustain the Center's basic and translational research activities, and obtain new extramural support.

近三分之二的美国人口处于临床超重或肥胖状态，近 10% 的人口患有成人糖尿病。路易斯安那州的发病率甚至更高这一事实为肥胖和糖尿病研究提供了公共卫生紧迫性彭宁顿生物医学中心生物医学研究卓越中心的赞助研究中心。肥胖、糖尿病或代谢综合征的基础和临床研究需要基因组学方法来了解潜在的分子机制各自的病理。 PBRC COBRE 的基因组学核心致力于促进此类工作通过提供通常过于昂贵的现代基因组学技术来进行查询大多数个体实验室都需要采购或维护。根据科学要求 COBRE 和 PBRC 研究人员，核心重点关注“功能基因组学”，基因表达测量和表观基因组学方法处于中心阶段。具体核心目标是 (1) 提供高质量且具有成本效益的基因组学技术向研究人员提供，(2) 提供分析和解释所需的生物信息学基因组学实验的框架，以及（3）作为知识和咨询资源促进对基因组学感兴趣的研究人员之间的互动和合作接近。基于前两个资助期的良好生产力记录 PBRC COBRE，基因组学核心的影响来自于促进研究进步，消除关键障碍，特别是在生物信息学领域，以及通过与细胞生物学和生物成像核心的相互作用创造科学协同作用转基因核心、PBRC 和 COBRE 研究人员。因此，基因组学核心是一个关键维持中心的基础和转化研究活动，并获得新的校外支持。