COBRE: UNE MED CTR: CORE B: MOUSE GENOME ENGINEERING

COBRE：UNE MED CTR：核心 B：小鼠基因组工程

• 批准号: 7960544
• 负责人: J Michael Salbaum
• 金额: $ 13.19万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960544
• 关键词: Animal Model; Biomedical Research; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Extramural Activities; Fostering; Funding; Future; Generations; Genes; Genome engineering; Goals; Grant; Healthcare; Human; Institution; Knockout Mice; Molecular Biology; Molecular Profiling; Mus; Recruitment Activity; Research; Research Personnel; Resources; Services; Site; Source; System; Transgenic Organisms; United States National Institutes of Health; boys; experience; mouse genome; mouse model; neurosurgery; research study; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One goal of this COBRE proposal is to establish the triangle UNMC-Creighton-Boys Town NRH as a recognized Center of Research Excellence in Neurosensory Development. With the commitment of all three institutions to human health care, the mouse will be the paramount model organism for future biomedical research on this topic. The presence and availability of a Mouse Core will, therefore, not only benefit the initial COBRE Investigators through the on-site establishment of the pertinent mouse models, but will serve as an essential recruiting tool once the initial COBRE Investigators will rotate off and new Investigators will be brought aboard. We anticipate that such recruits will also focus on the mouse, use genetically manipulated mice to advance their research. In particular, junior Investigators with limited experience with mice would greatly benefit from Mouse Core support services. Furthermore, we expect that the expression profiling experiments of several projects of this proposal will yield results that merit the generation of new transgenic and knockout mouse models for the respective genes in order to study their function in neurosensory development. We are therefore convinced that the availability of a Mouse Core will significantly enhance the competitiveness of new applications for extramural funding that are fostered by this COBRE proposal.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 COBRE 提案的目标之一是建立三角 UNMC-Creighton-Boys Town NRH 作为 公认的神经感觉发育卓越研究中心。在所有人的承诺下 人类医疗保健三大机构，小鼠将成为未来最重要的模式生物 关于该主题的生物医学研究。因此，鼠标核心的存在和可用性不会 仅通过相关小鼠的现场建立使最初的 COBRE 研究人员受益 模型，但一旦最初的 COBRE 调查员轮换，将成为一个重要的招聘工具 新的调查员将被带上船。我们预计此类招聘也将集中于 小鼠，使用基因操纵小鼠来推进他们的研究。特别是初级研究者 使用鼠标的经验有限的人将大大受益于 Mouse Core 支持服务。 此外，我们期望该提案的几个项目的表达谱实验 将产生值得产生新的转基因和基因敲除小鼠模型的结果 各自的基因，以研究它们在神经感觉发育中的功能。我们因此 确信鼠标核心的推出将显着增强新产品的竞争力 此 COBRE 提案促进了外部资金的申请。