COBRE PHASE III: Center for Neuroplasticity at the University of Puerto Rico

COBRE 第三阶段：波多黎各大学神经可塑性中心

基本信息

批准号：
10628974
负责人：
JOSE Antonio LASALDE-DOMINICCI
金额：
$ 105.45万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628974
关键词：
Advisory Committees Alcohols Anatomy Animals Applications Grants Area Award Basic Science Benchmarking Biology Biomedical Research Businesses Centers of Research Excellence Chemistry Clinical Research Collaborations Communities Contract Services Core Facility Cyclic GMP Development Disease Educational workshop Electrophysiology (science)Ensure Entrepreneurship Faculty Familiarity Fees Floor Fluorescence Fostering Funding Goals Grant IACUC Image Industry Institution Interdisciplinary Study Investigation Investments Leadership Medical Mental disorders Mentors Mentorship Microscope Microscopy Molecular Nerve Degeneration Neurobiology Neuronal Plasticity Neurosciences Participant Pharmacology Pharmacy facility Phase Physiology Pilot Projects Principal Investigator Privatization Productivity Puerto Rico Qualifying Research Research Infrastructure Research Personnel Research Project Grants Resources Science Scientist Services Slide Source Therapeutic Training United States National Institutes of Health Universities addiction biomedical resource career design and construction experience industry partner innovation instrument instrumentation medical schools member multidisciplinary multiphoton microscopy nervous system disorder neural neuroadaptation neuroimaging neuroprotection patch clamp pre-clinical research preclinical study programs recruit square foot synergism translational applications

项目摘要

Project Summary (Overall section): The UPR COBRE Center for Neuroplasticity (UPR-CCfN) was established with a COBRE phase 1 award in 2013 as a collaboration of two main UPR campuses, the Institute of Neurobiology (UPR-MSC) and the Department of Biology at UPR Rio Piedras (UPR-RP). The UPR-CCfN has since expanded collaborations to include several UPR campuses, including the Departments of Biology and Chemistry (UPRRP), Departments of Physiology, Pharmacology, Pharmacy, and Anatomy (UPR-MSC), Department of Chemistry (UPR Humacao campus), and Universidad Central del Caribe Medical School, a private institution in PR. During COBRE phases 1-2 the UPR-CCfN achieved several benchmarks: (1) It has significantly enhanced ability of new and early-stage UPR researchers to conduct competitive research in the area of neuroscience. (2) It has established a critical mass of 24 investigators. (3) It has developed the COBRE Neuroimaging and Electrophysiology Facility (NIEF) core into a state-of-the-art resource for the UPR-CCfN investigators and the larger UPR biomedical research community. This was accomplished by providing outstanding specialized technical services, training, and access to state-of- the-art instrumentation in fluorescence, confocal, and multiphoton microscopy along with electrophysiology that has enhanced the productivity of our researchers. (4) A major accomplishment of the NIEF was becoming a Nikon Center of Excellence (NCoE), globally renowned for its state-of-the- art facilities for advanced research imaging. (5) The UPR-CCfN has extraordinarily increased its biomedical research capacity as it recently took occupancy of a new state-of-the-art research infrastructure, which includes a more than $26 million institutional investment on two floors (~40 square feet) of the Molecular Science Research Center (MSRC); the Neuroplasticity Center (floor 6); and Vivarium (floor 7). (6) UPR-CCfN has developed a robust business plan that will sustain and upgrade our NIEF core facilities, provide technical support, and programmatic activities beyond COBRE Phase 3. During Phase 3 the UPR-CCfN will continue to provide a multidisciplinary cadre of investigators with cutting-edge facilities, scientific capability, and multidisciplinary collaborations with the public and biopharma sectors for the treatment of neurodegeneration-related diseases. The UPR-CCfN will foster research innovation, maximize research synergy and collaborations as well as mentoring and entrepreneurship. Our overreaching goal is that during Phase 3, the UPR-CCfN will propel into a world- recognized Center for Neuroplasticity and Neurodegeneration with translational/therapeutic applications.

项目概要（总体部分）： UPR COBRE 神经可塑性中心 (UPR-CCfN) 成立并获得 COBRE 第一阶段奖项 2013 年，作为 UPR 两个主要校区、神经生物学研究所 (UPR-MSC) 和 UPR Rio Piedras 生物系 (UPR-RP)。 UPR-CCfN 此后已扩大合作涉及多个 UPR 校区，包括生物系和化学系（UPRRP），生理学、药理学、药学和解剖学系（UPR-MSC），化学系（UPR Humacao 校区）和加勒比中央大学医学院，公关领域的私人机构。在 COBRE 第 1-2 阶段期间，UPR-CCfN 实现了多项基准：(1) 它显着增强了新的和早期的UPR研究人员进行竞争性研究的能力神经科学领域的研究。 (2) 已建立了 24 名调查员的临界数量。（3）它有将 COBRE 神经影像和电生理学设施 (NIEF) 核心开发成最先进的为 UPR-CCfN 研究人员和更大的 UPR 生物医学研究界提供资源。这是通过提供出色的专业技术服务、培训和获得最新状态的机会来实现荧光、共焦和多光子显微镜方面最先进的仪器电生理学提高了我们研究人员的生产力。（四）重大成果 NIEF 正在成为尼康卓越中心 (NCoE)，因其最先进的技术而享誉全球。用于高级研究成像的艺术设施。 (5) UPR-CCfN 大幅增加了其生物医学研究能力，因为它最近进行了一项新的最先进的研究基础设施，其中包括对两层楼（约 40 平方米）的超过 2600 万美元的机构投资英尺）的分子科学研究中心（MSRC）；神经可塑性中心（6 楼）；和动物园（7 楼）。 (6) UPR-CCfN 制定了稳健的业务计划，将维持和升级我们的 NIEF 核心设施，提供 COBRE 阶段之外的技术支持和计划活动 3. 在第 3 阶段，UPR-CCfN 将继续为多学科调查员队伍提供尖端的设施、科学能力以及与公众和公众的多学科合作用于治疗神经退行性疾病相关疾病的生物制药部门。 UPR-CCfN 将促进研究创新，最大限度地发挥研究协同作用和合作以及指导和创业。我们的远大目标是，在第三阶段，UPR-CCfN 将推动进入一个世界—— 公认的神经可塑性和神经退行性转化/治疗中心应用程序。