Omega-3 Supplementation and Adolescent Behavior

Omega-3 补充剂和青少年行为

• 批准号: 9977207
• 负责人: JIANGHONG LIU
• 金额: $ 48.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977207
• 关键词: Adolescent; Adolescent Behavior; Adult; Aggressive behavior; Behavioral; Benign; Biological; Brain; Brain imaging; Caregivers; Child; Child Development; Child Health; Clinical; Cognitive; Communities; Conduct Disorder; Data; Development; Dietary Intervention; Double-Blind Method; Emotional; Epidemiology; General Population; Goals; Health; Impairment; Individual; Intervention; Mediating; Mental Health; Mental disorders; Motor; Neurobiology; Neurocognitive; Neurocognitive Deficit; Occupational; Omega-3 Fatty Acids; Outcome; Parents; Prevention approach; Preventive Intervention; Problem behavior; Process; Public Health; Quality of life; Randomized; Research; Risk Factors; Savings; Side; Social Functioning; Societies; Structure; Supplementation; Violence; Yang; Youth; anti social; antisocial behavior; base; behavioral study; clinical practice; economic cost; externalizing behavior; imaging study; intergenerational; long chain fatty acid; novel; novel strategies; nutrition; perpetrators; placebo controlled trial; primary caregiver; social; transmission process; violence perpetration

Project Summary Despite increasing evidence for a significant neurobiological basis to aggression, biological interventions have been largely side-stepped, despite the fact that violence is a global public health problem. An important need is to develop socially acceptable ways of bettering brain functioning to reduce adolescent behavior problems, a critical developmental stage for adult violence perpetration and mental health problems. This is the primary health challenge that this proposal aims to tackle. Our pilot data documents that omega-3, a long-chain fatty acid which is critical for brain structure and function, reduces behavior problems in children and adolescents six months after the end of supplementation. If we can further document support and extension of our pilot findings with dual supplementation to both parent and adolescent, and if we can begin to identify the mechanisms of action underlying change, this can provide a new vista on biological interventions for adolescent externalizing problems that predispose to violence. Our overarching, long-term goals are to develop a non-invasive biological approach to prevention of youth aggression, and ultimately adult violence. The specific aims of this 2 x 2 randomized, double-blind, stratified, placebo-controlled trial of omega-3 supplementation to adolescents and caregivers are: (1) to investigate whether a nutritional intervention to adolescents and their parents can reduce externalizing behavior problems; (2) to examine the impact of a dual nutritional intervention to both parents and adolescents on adolescent externalizing behavior problems; (3) to identify mechanisms of action by which omega-3 supplementation impacts externalizing behavior in adolescents. It is expected that omega-3 supplementation will reduce adolescent behavior problems, and that dual supplementation to both the caregiver and adolescent will result in exponential improvements in adolescent behavior. A secondary prediction is that improvements in neurocognitive functioning will partially account for any behavioral improvements observed. Effects on scholastic ability are also explored. The paradigm-shift that could influence clinical practice is the use of a biological intervention that is not solely focused on the adolescent, but which is also applied to the primary caregiver. To our knowledge, such dual supplementation has never been examined. From an epidemiological standpoint, if this dual intervention approach could reduce even modestly the overall level of aggressive and antisocial behavior in the community at large, there is the promise of enhancing child health and development with a clinical paradigm novel in the biological study of behavior problems. The study's significance extends beyond adolescent behavior problems, which predispose not just to later adult violence, but also a wide array of adult psychiatric disorders. These adult outcomes result in an enormous societal burden in terms of economic costs, reduced occupational functioning, social functioning, and quality of life for both victims and perpetrators, a burden which could be significantly ameliorated if our pilot findings are supported.

项目概要 尽管越来越多的证据表明攻击性具有重要的神经生物学基础，但生物学 尽管暴力是一个全球公共卫生问题，但干预措施基本上被回避了。 一个重要的需要是开发社会可接受的方法来改善大脑功能，以减少青少年 行为问题，这是成人暴力实施和心理健康问题的关键发展阶段。 这是本提案旨在解决的主要健康挑战。我们的试验数据证明 omega-3 长链脂肪酸对大脑结构和功能至关重要，可减少儿童的行为问题和 补充结束后六个月的青少年。如果我们可以进一步记录支持和扩展 我们对父母和青少年进行双重补充的试点结果，以及我们是否可以开始确定 改变潜在的行动机制，这可以为生物干预提供新的前景 青少年将容易发生暴力的问题外化。我们的总体长期目标是发展 采用非侵入性生物方法来预防青少年的攻击行为，并最终预防成人的暴力行为。 这项 2 x 2 随机、双盲、分层、安慰剂对照 omega-3 试验的具体目标 对青少年和照顾者的补充是：（1）调查营养干预是否可以 青少年及其父母可以减少外化行为问题； (2) 检验双重影响 针对青少年外化行为问题对父母和青少年进行营养干预； (3) 至 确定 omega-3 补充剂影响外化行为的作用机制 青少年。预计补充 omega-3 将减少青少年行为问题，并且 对看护者和青少年的双重补充将带来指数级的改善 青少年行为。第二个预测是神经认知功能的改善将部分地 解释观察到的任何行为改善。还探讨了对学业能力的影响。 可能影响临床实践的范式转变是使用非生物干预措施 只关注青少年，但也适用于主要照顾者。据我们所知，这样的 双重补充从未被研究过。从流行病学的角度来看，如果这种双重干预 这种方法甚至可以稍微降低社区中攻击性和反社会行为的总体水平 总的来说，通过新颖的临床范式有望增强儿童的健康和发展 行为问题的生物学研究。这项研究的意义不仅限于青少年行为问题， 这不仅会导致后来的成人暴力，还会导致一系列成人精神疾病。这些 成人结果导致巨大的社会负担，包括经济成本、职业减少等。 受害者和犯罪者的功能、社会功能和生活质量，这可能是一种负担 如果我们的试点结果得到支持，情况会显着改善。