Physics of Cancer Microfabrication

癌症微加工物理学

• 批准号: 8381714
• 负责人: Peter C Searson
• 金额: $ 6.72万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8381714
• 关键词: Adhesiveness; Adhesives; Cancer Center; Devices; Equipment; Extracellular Matrix; Extravasation; Laboratories; Malignant Neoplasms; Microfabrication; Microfluidics; Neoplasm Metastasis; Physics; Postdoctoral Fellow; Process; Protocols documentation; Recovery; Research Personnel; Resources; Schedule; Surface; Training; base; cell motility; cost; insight; lithography; operation; research study

The Microfabrication Core will be established to support the investigators in the Cancer Physics Center, specifically to provide resources for microfabrication and soft-lithography. The Core will mainly support Projects 2 and 3 in the Center. For example, adhesive micropatterned surfaces will be used to study the influence of geometry on motility. In another example, microfluidic-based devices will be fabricated to study the influence of steric forces, extracellular matrix, cell compliance, and adhesiveness on tumor cell migration. These experiments will provide new insight into the process of intravasation and extravasation. The core will be located at the Hopkins' Homewood campus in 600 sq. ft. of dedicated laboratory space. The Core will be managed and administered as a user facility with well established protocols for: scheduling, managing and maintaining equipment, training, providing oversight of users, and billing and cost recovery. Two post-doctoral associates will be responsible for the day-to-day operation, including fabrication of devices and platforms for researchers in the Center, the training of researchers in microfabrication, and the oversight of self-users in the facility.

将建立微观加工核心，以支持癌症物理中心的研究人员，特别是为了提供微型制作和软性刻痕的资源。核心将主要在中心支持项目2和3。例如，将使用粘合性微图案表面来研究几何学对运动的影响。在另一个例子中，将制造基于微流体的设备以研究 空间力，细胞外基质，细胞依从性以及肿瘤细胞迁移的粘附性。这些实验将为侵入和渗出过程提供新的见解。核心将位于霍普金斯的霍姆伍德校园，位于600平方英尺的专用实验室空间。核心将作为用户设施进行管理和管理，该设施具有良好的协议：调度，管理和维护设备，培训，提供对用户的监督以及计费和成本恢复。两名博士后同事将负责日常运营，包括为中心的研究人员制造设备和平台，微加工研究人员的培训以及设施中的自我使用者的监督。