INOSITOL 1,4,5 TRIPHOSPHATE RECEPTOR (IP3R)

肌醇 1,4,5 三磷酸受体 (IP3R)

• 批准号: 7598589
• 负责人: Irina I Serysheva
• 金额: $ 2.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598589
• 关键词: Apoptosis; Atherosclerosis; Cells; Cerebellum; Complex; Computer Retrieval of Information on Scientific Projects Database; Defect; Endoplasmic Reticulum; Fertilization; Funding; Genes; Genetic Transcription; Grant; Heart Hypertrophy; Heart failure; Homo; Hormones; ITPR1 gene; Individual; Inherited Spinocerebellar Degenerations; Inositol; Inositol 1,4,5-Trisphosphate; Institution; Ions; Mammals; Metabolic; Migraine; Molecular; Osteoporosis; Play; Population; Protein Isoforms; Proteins; Regulation; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; cell type; human disease; neurotransmitter release; receptor; tripolyphosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are the intracellular Ca2+ release channels gated by inositol 1,4,5-trisphosphate (IP3). These channels allow rapid fluxes of Ca2+ ions from the endoplasmic reticulum, thereby playing a key role in neurotransmitter release, fertilization, hormone secretion, gene transcription, metabolic regulation and apoptosis. In mammals, 3 different IP3R genes, sharing ~70% homology, are expressed. Individual cell types can express more than one isoform, and they may form homo- or hetero-tetrameric populations. The type 1 IP3R (IP3R1) is the predominant type in the cerebellar endoplasmic reticulum (ER), forming homo-tetramers with a Mr over 1.2 MDa. The cerebellum is generally used as a primary source for purification of the IP3R1 for structure-function characterization. The long-term objectives of this project are to determine the molecular mechanisms of the IP3-induced Ca2+-gating through structure-function analysis of the IP3R channel complex and to define how defects in this channel protein can cause abnormal regulation of cell Ca2+ level underlying human diseases such as cardiac hypertrophy, heart failure, hereditary ataxias, osteoporosis, atherosclerosis and some migraines.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肌醇1,4,5-三磷酸受体（IP3RS）是细胞内Ca2+释放通道，由肌醇1,4,5-三磷酸（IP3）配对。这些通道允许内质网的Ca2+离子快速通量，从而在神经递质释放，受精，激素分泌，基因转录，代谢调节和凋亡中起关键作用。 在哺乳动物中，表达了3种不同的IP3R基因，共享约70％的同源性。单个细胞类型可以表达多种同工型，并且它们可能形成同型或异种群体。 1型IP3R（IP3R1）是小脑内质网（ER）中的主要类型，形成MR超过1.2 MDA的同性恋者。小脑通常用作纯化IP3R1进行结构功能表征的主要来源。 The long-term objectives of this project are to determine the molecular mechanisms of the IP3-induced Ca2+-gating through structure-function analysis of the IP3R channel complex and to define how defects in this channel protein can cause abnormal regulation of cell Ca2+ level underlying human diseases such as cardiac hypertrophy, heart failure, hereditary ataxias, osteoporosis, atherosclerosis and some migraines.