Core B-Clinical Core

核心 B-临床核心

• 批准号: 9922101
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 61.75万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922101
• 关键词: Alzheimer associated neurodegeneration; Alzheimer' s Disease; Amyloid; Ancillary Study; Asian Americans; Asians; Autopsy; Biochemical; Biological Markers; Blood; Blood Vessels; Brain; California; Cardiovascular system; Cell Line; Cerebrospinal Fluid; Cessation of life; Chinese American; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical assessments; Cognitive; Collaborations; Collection; Consent; Data; Data Set; Dementia; Deposition; Diagnostic; Disease; Ecosystem; Education; Enrollment; Ethnic Origin; Female; Fibroblasts; Funding; Generations; Genetic; Hispanics; Home environment; Image; Impaired cognition; Individual; Investigation; Link; Longevity; Longitudinal cohort; Magnetic Resonance Imaging; Methodology; Minority; Mission; Molecular; Neurocognitive; Neurologic; Participant; Peripheral Blood Mononuclear Cell; Population; Positron-Emission Tomography; Procedures; Punch Biopsy; Questionnaires; Race; Randomized; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Risk; Role; Sampling; Skin; Spinal Puncture; Symptoms; System; Telephone; Telephone Interviews; Tissue Donations; Training; Training and Education; Translational Research; Universities; clinical trial participant; cognitive testing; cohort; data management; demented; disorder risk; education research; follow-up; genetic analysis; improved; inclusion criteria; induced pluripotent stem cell; innovation; mild cognitive impairment; neuroimaging marker; next generation; novel; outreach; pre-clinical; programs; recruit; retention rate; stem cells; tau Proteins; tissue biomarkers

Core B: Clinical Core Project Summary/Abstract The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS, participants and their study partners complete questionnaires and assessments unique to our ADRC, and voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify, quantify, and validate factors that influence the risk of AD across the lifespan.”!

核心 B：临床核心 项目概要/摘要 UCI ADRC 临床核心招募、描述和跟踪一群认知能力较差的个体 未受损、认知受损或痴呆，每个人都完成统一数据集 (UDS) 除了 UDS 之外，还包括一系列身体和神经学检查以及一系列神经认知评估。 参与者及其研究伙伴完成 ADRC 特有的调查问卷和评估，以及 自愿贡献各种组织和生物标志物评估，包括遗传分析、体积分析 成像、脑脊液分析和成纤维细胞捐赠以产生诱导多能干细胞 总体而言，我们目前的 330 名活跃参与者中有 292 名捐赠了成纤维细胞或外周血。 单核细胞 (PBMC)，已被我们的 iPSC Core Most 用于生成 192 个 iPSC 系。 参与者同意在尸检时捐献大脑，我们尸检的成功完成率很高 我们的 UDS 队列目前包括 330 名活跃参与者，其中 60% 是死亡时确认的。 女性，三分之一是非白人或西班牙裔，百分之十九患有精神错乱，百分之十八患有精神错乱。 轻度认知障碍 (MCI) 的诊断标准，大多数 (60%) 不符合 MCI 的诊断标准或 我们的总体保留率非常高，高于 ADRC 系统的中位数。 参与者已参加外部资助的辅助研究，包括电话访谈研究 支持 ADRC 研究人员不断增长的需求，包括新颖的神经影像生物标志物研究。 分子和血管生物标志物的研究，我们将把这个 UDS 队列发展到稳定状态 n=400， 重点关注招募能够进行新颖研究以支持 UCI ADRC 主题“识别、 量化并验证影响整个生命周期 AD 风险的因素。”！