CORE--CLINICAL

核心--临床

• 批准号: 6932809
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 25.01万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932809
• 关键词: Alzheimer' s disease; Downs syndrome; aging; biomedical facility; clinical research; human data; human subject; neurobiology; neuropathology; neuropsychology; patient /disease registry; postmortem

The principal functions of the Clinical Core of the UCI ADRC are: to recruit, characterize, and longitudinally follow subjects as part of our clinical and neurobiological investigations of aging and Alzheimer's disease, and to provide a resource for all investigators involved in the study of aging and AD at UCI and nationally by providing well-characterized subjects for clinical trials, genetic studies, tissue repositories, and imaging protocols. With this renewal the Clinical Core has responded to the RFA and the needs of our investigators by assembling three cohorts of subjects to examine the cognitive states associated with old age and Down syndrome. Extending our previous cohort of subjects (the Clinical Cohort, N=250), the Core has added two special interest groups of subjects. The 90+ Autopsy Cohort (N=100) provides unique opportunities to better understand the brain/behavior relationships and effects of aging in the most rapidly growing segment of the population, the oldest old. Our center also brings to the ADC system another unique cohort, the adult Down Syndrome Cohort (N=75). These subjects are followed with the same methodology used for all ADRC subjects, and provide opportunities for innovative investigations by our basic and clinical scientists. Brain donation is requested from all ADRC subjects, and is required on enrollment, except for DS subjects (50% autopsy participation) and minorities. We aggressively work to increase autopsy participation in these subjects. The Clinical Core, with expertise in neurology, neuropsychology, and nursing, interacts closely with all ADRC cores, NACC, and local and national researchers. Supporting the ADRC's experimental studies, the Clinical Core provides subjects and clinical data to Project 1, biological tissues and clinical data to Project 2, and human data for comparison studies in the transgenic investigations of Project 3. With our unique subject populations, the ADRC Clinical Core brings to UCI and the ADC system a central resource for innovative studies of aging and AD.

UCI ADRC 临床核心的主要职能是：招募、表征和 纵向跟踪受试者，作为我们对衰老和阿尔茨海默氏病的临床和神经生物学研究的一部分，并通过为临床试验、基因研究、组织储存库和成像协议。通过此次更新，临床核心响应了 RFA 和我们研究人员的需求，召集了三组受试者来检查与老年和唐氏综合症相关的认知状态。扩展了我们之前的受试者队列（临床队列，N=250），核心添加了两个 学科的特殊兴趣群体。 90 岁以上尸检队列（N = 100）提供了独特的机会，可以更好地了解人口增长最快的部分（最年长的老年人）的大脑/行为关系以及衰老的影响。我们中心还为 ADC 系统带来了另一个独特的队列，即成人唐氏综合症队列 (N=75)。这些科目采用与所有 ADRC 科目相同的方法，并为我们的基础和临床科学家的创新研究提供了机会。除 DS 受试者（50% 尸检参与）和少数族裔外，所有 ADRC 受试者均要求脑部捐赠，并且在入组时必须进行。我们积极努力增加尸检参与度 科目。临床核心拥有神经病学、神经心理学和护理方面的专业知识，与所有 ADRC 核心、NACC 以及当地和国家研究人员密切互动。临床核心支持 ADRC 的实验研究，为项目 1 提供受试者和临床数据，为项目 2 提供生物组织和临床数据，为项目 3 的转基因研究中的比较研究提供人体数据。凭借我们独特的受试者群体，ADRC 临床中心Core 为 UCI 和 ADC 系统带来了衰老和 AD 创新研究的核心资源。