Clinical and Pathological Studies in the Oldest Old

最古老的临床和病理学研究

基本信息

批准号：
7496763
负责人：
CLAUDIA H. KAWAS
金额：
$ 20.39万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-15 至 2008-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7496763
关键词：
Activities of Daily Living Age Age-Years Aged, 80 and over Aging Alleles Alzheimer&apos s Disease American Anti-Inflammatory Agents Anti-inflammatory Antioxidants Apolipoprotein E Ascorbic Acid Brain Cerebrum Cessation of life Characteristics Cholesterol Clinical Cognition Cognitive Cohort Studies Commit Condition Data Dementia Diet Disease Drops Drug usage Environmental Risk Factor Epidemiology Exercise Family history of Folate Frequencies Genetic Genotype Goals Habits Health Homocysteine Homocystine Ibuprofen Impaired cognition Incidence Individual Injury Intake Investigation Life Life Style Lipids Longevity Lower Extremity Measures Medical History Neurofibrillary Tangles Numbers Nutrient Oxidative Stress Pathology Performance Pharmaceutical Preparations Population Prevalence Proteins Range Rate Reporting Risk Risk Factors Sampling Studies Serum Folate Level Societies Vitamins aged aging brain cognitive function cohort experience falls follow-up functional decline member mortality neuroinflammation normal aging prospective social

项目摘要

CLINICAL ANDPATHOLOGICAL STUDIES IN THE OLDEST OLD In the next two decades, the numberof Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. The goals of this proposal are to investigate clinical,genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatorydrugs (NSAIDS). Our central hypothesis is that oxidative damage and inflammationin the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improvethe health of the oldest old. Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatorymarkers, and plaqueand tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatorycompounds. The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.

老年人的临床和病理学研究未来20年，90岁及以上的美国人数量将几乎翻倍，达到300万以上。由于之前的研究很少（如果有的话）年龄超过 90 岁的受试者，因此人们对这些先驱者或有关与该群体成功老龄化和健康相关的因素。该提案的目标是调查与高龄相关的临床、遗传和病理因素。我们将我们的调查与 1981 年启动的休闲世界队列研究相结合。20 多年来，队列研究会员 (N=13,979) 提供了病史和生活方式信息，包括疾病状况、家庭情况病史、锻炼、社交活动和药物使用，例如抗氧化剂和非甾体抗炎药（非甾体抗炎药）。我们的中心假设是，大脑中的氧化损伤和炎症会导致衰老、疾病和死亡，摄入抗氧化剂和非甾体抗炎药将减缓认知能力下降并改善老年人的健康。我们的具体目标是：(1) 检查 4,682 名达到该年龄的队列成员中与长寿相关的因素 90 人与未这样做的 6734 人进行比较，(2) 确定 1,644 人中痴呆症的患病率、发病率和危险因素 10 岁和 11 岁的在世队列成员，(3) 进行纵向随访以衡量这些年龄最大的老年受试者的认知和功能下降，以及（4）完成我们的临床研究健康和疾病中大脑衰老的病理相关性，重点关注大脑测量的关联氧化损伤、炎症标志物以及斑块和缠结病理学，因为它与临床状态和既往使用情况有关抗氧化剂和抗炎化合物。休闲世界队列研究为遗传和环境研究提供了独特的人群样本与老年人的长寿和成功老龄化相关的因素。拥有大量致力于主题和 20 年的前瞻性数据，我们提出的调查可以为理解做出很大贡献我们社会最年长成员的认知、功能能力和脑病理学。