Claude D Pepper Older Americans Independence Center

克劳德·D·佩珀 (Claude D Pepper) 美国老年人独立中心

• 批准号: 7286346
• 负责人: ANDREW P GOLDBERG
• 金额: $ 137.17万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286346
• 关键词: Claude; Pepper; Older; Americans; Independence

DESCRIPTION (provided by applicant): The mission of the University of Maryland OAIC renewal is to conduct exercise and motor learning based rehabilitation research to optimize the recovery of older adults who have suffered a stroke, hip fracture or other chronic debilitating disease, and translate these findings into effective community-based rehabilitation programs. This will be accomplished through specific aims to: 1) conduct basic and clinical research examining the mechanisms underlying functional disabilities associated with chronic diseases of aging to characterize the functional impairments that define the disability phenotype across domains of neuromotor, muscular, metabolic, cardiovascular and psychosocial function; 2) apply these scientific findings to design novel exercise and motor learning-based rehabilitation strategies; 3) determine the mechanisms by which these rehabilitation interventions improve functional and clinical outcomes in older people with functional impairments; 4) translate efficacious rehabilitation strategies into community-based clinical studies; 5) support Pilot Exploratory Core (P/EC) Projects that study the mechanisms underlying the disability phenotype and functional and clinical responses to rehabilitation; and 6) foster the career development of junior faculty awardees (JFA's) into independent investigators and academic leaders in aging research. Our impetus to study rehabilitation in disability and aging is its critical importance for the health and quality of lifestyle older people living with chronic disability, and the dearth of mechanistic and translational research in this area of investigation. The UNIVERSITY OF MARYLAND-OAIC has an accomplished leadership team with expertise in aging research, administration and monitoring large programs, and assembling and motivating a multidisciplinary team of investigators. There is a Research Career Development Core (RCDC) that provides a mentor-based training program to promote the career development of JFA's, a P/EC with 5 studies congruent with OAIC goals, and 5 RCs in 1) Clinical and Translational Research Methods, 2) Neuromotor Function, 3) Applied Clinical Physiology, 4) Muscle Biology and Molecular Mechanisms of Inflammation, and 5) Biostatistics and Informatics. We are optimistic that UNIVERSITY OF MARYLAND-OAIC's research will change clinical practice by developing innovative, evidence-based exercise and motor learning rehabilitation programs that improve the functional and clinical outcomes of older people with disabilities to promote their recovery and independent living.

描述（由申请人提供）：马里兰州OAIC大学更新的使命是进行运动和运动学习的康复研究，以优化患有中风，髋部骨折或其他慢性衰老疾病的老年人的恢复，并将这些发现转化为有效的社区康复计划。这将通过以下特定目的来完成：1）进行基本和临床研究，研究与衰老慢性疾病相关的功能障碍的基本机制，以表征跨神经动物，肌肉，代谢，心血管和心理社会功能的跨性别障碍的功能障碍； 2）将这些科学发现应用于设计新颖的运动和基于运动学习的康复策略； 3）确定这些康复干预措施改善功能障碍老年人的功能和临床结果的机制； 4）将有效的康复策略转化为基于社区的临床研究； 5）支持试点探索性核心（P/EC）项目，该项目研究了残疾表型以及功能和临床对康复的临床反应的机制； 6）将初级教师获奖者（JFA）的职业发展促进了衰老研究的独立研究人员和学术领导者。我们在残疾和衰老中研究康复的动力是其对生活方式的健康和质量的至关重要的重要性，在这一调查领域的机械性和转化研究的缺乏以及缺乏机械性和转化研究。马里兰州 - 俄亥俄州大学拥有一支成就卓著的领导团队，具有老化的研究，管理和监视大型计划，以及组装和激励多学科研究人员的专业知识。有一个研究职业发展核心（RCDC）提供了基于导师的培训计划，以促进JFA的职业发展，P/EC，具有5个与OAIC目标一致的P/EC，以及5个RC，1）临床和翻译研究方法，2）Neuromotor功能，3）应用临床生理学，4）肌肉生物学和分子机械学及5）。 我们很乐观的是，马里兰州 - 俄亥俄州大学的研究将通过开发创新的，基于循证的运动和运动学习康复计划来改变临床实践，从而改善老年人残障人士的功能和临床结果，以促进其康复和独立生活。