Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional)

Claude D. Pepper 美国老年人独立中心（P30 临床试验可选）

• 批准号: 10294028
• 负责人: Richard H Fortinsky
• 金额: $ 148.41万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10294028
• 关键词: ARHGEF5 gene; Address; Affect; Aging; American; Area; Award; Behavior; Behavioral; Biological; Biological Markers; Capsicum; Caring; Clinical; Clinical Investigator; Clinical Trials; Cognition; Communities; Development; Discipline; Disease; Education; Effectiveness of Interventions; Elderly; Ensure; Environmental Risk Factor; Epidemiologist; Foundations; Funding; Genomic medicine; Geriatrics; Gerontology; Geroscience; Goals; Growth; Health; Heterogeneity; Home; Host Defense; Individual; Institution; Intervention; Knowledge; Leadership; Learning; Life; Medical Genetics; Mission; Outcome; Physiological; Pilot Projects; Research; Research Methodology; Research Personnel; Resources; Science; Scientist; Techniques; Testing; The Jackson Laboratory; Time; base; bench to bedside; career; clinical care; clinical translation; collaborative approach; community engagement; data resource; design; education research; experience; improved; innovation; insight; interdisciplinary approach; multidisciplinary; multiple chronic conditions; next generation; novel; novel strategies; population based; pre-clinical; pre-clinical research; precision medicine; preference; programs; ranpirnase; recruit; research study; social; social factors; synergism; tool; treatment response

PROJECT SUMMARY OVERALL This proposal seeks to establish the Claude D Pepper Older Americans Independence Center at UConn (UConn OAIC) with the overarching goal of developing clinical strategies for enhancing function and independence in older adults that are more precise, personalized, and effective. Our focus on Precision Gerontology has emerged through the collective experiences and insights of our multidisciplinary team of accomplished investigators in the UConn Center on Aging – all united by a shared commitment to improving the lives of older adults through research, education, and clinical care. Our emphasis on Precision Gerontology has been guided by three principles: 1. A growing heterogeneity or variability over time among individuals involving all aspects of aging that therefore necessitates a multidisciplinary team-based approach to aging research; 2. Increased heterogeneity or variability with aging in older adults’ responses to treatment, highlighting the need for better targeting; and 3. Recognition of a need to incorporate these considerations into the design and testing of novel geroscience-guided therapies. These objectives will be achieved by establishing a UConn OAIC through the coordinated activities of a Leadership and Administration Core (LAC), Recruitment and Community Engagement Core (RC1), Data Resource Core (RC2), Biomarker and Preclinical Research Core (RC3), Pilot and Exploratory Studies Core (PESC), and Research Education Component (REC). We will seek to address these goals through the following aims: Aim 1: To develop and refine new approaches to the study and clinical translation of Precision Gerontology. Aim 2: To develop and evaluate new research methods, techniques, and collaborative approaches required to advance the goals of Precision Gerontology. Aim 3: To identify, develop, and learn from experiences of the next generation of researchers poised to become leaders in geriatrics research related to the UConn OAIC focus. Aim 4: To select and support innovative pilot studies that show promise in helping to guide the design, funding, and completion of more definitive future research studies related to the UConn OAIC focus.

总体项目摘要 该提议旨在建立克劳德·普斯（Claude d Pepper）年龄较大的美国人独立中心 在UCONN（UCONN OAIC），其总体目标是制定临床策略 在更精确，个性化的老年人中增强功能和独立性 有效的。通过集体经验，我们对精确老年病的关注已经出现 以及我们在UCONN中心的跨学科研究人员的见解 衰老 - 全都通过共同致力于改善老年人生活的共同承诺 研究，教育和临床护理。 我们对精确的老年病的强调是由三个原则指导的：1。 个体之间的异质性或变异性，涉及衰老的各个方面 因此，必要的主题是一种基于多学科的团队研究的方法； 2。增加 在老年人对治疗的反应中，异质性或变异性随着衰老而变化，突出了 需要更好的定位； 3。认识到将这些考虑因素纳入 新型Geroscience引导疗法的设计和测试。 这些目标将通过通过协调的 领导力和管理核心（LAC），招聘和社区的活动 参与核心（RC1），数据资源核心（RC2），生物标志物和临床前研究 核心（RC3），飞行员和探索性研究核心（PESC）和研究教育部分 （rec）。 我们将寻求通过以下目标来解决这些目标： 目的1：开发和完善精度研究和临床翻译的新方法 老年学。 目标2：开发和评估新的研究方法，技术和协作 促进精确老年病目标所需的方法。 目标3：识别，发展和学习下一代研究人员的经验 准备成为与UConn OAIC重点有关的老年医学研究领导者。 目标4：选择和支持创新的试点研究，以显示有望帮助指导 设计，资金和完成更确定的未来研究研究 UCONN OAIC重点。