Adjunctive Psychotherapy for Teens with Bipolar Disorder

双相情感障碍青少年的辅助心理治疗

• 批准号: 7595739
• 负责人: STEFANIE A HLASTALA
• 金额: $ 14.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595739
• 关键词: Academy; Address; Adolescence; Adolescent; Adolescent Psychiatry; Adoption; Adult; Affective; American; Applications Grants; Area; Attention; Award; Behavioral; Bipolar Disorder; Child; Clinical; Conduct Clinical Trials; Data; Development; Diagnosis; Disease; Disease remission; Emotional; Etiology; Family; Goals; Guidelines; Impairment; Individual; Intervention; Intervention Studies; Investigation; K-Series Research Career Programs; Knowledge; Life; Life Style; Manuals; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Mood Disorders; Morbidity - disease rate; Occupational; Outcome; Pathogenesis; Pharmacological Treatment; Phase; Pilot Projects; Population; Procedures; Process; Psychopathology; Psychosocial Assessment and Care; Psychosocial Factor; Psychotherapy; Publishing; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Reporting; Research; Research Personnel; Research Project Grants; Sampling; Schools; Specific qualifier value; Suicide; Supervision; Symptoms; Teenagers; Testing; Time; Training; Youth; career development; design; experience; follow-up; infancy; instrument; interpersonal therapy; medication compliance; meetings; mortality; neglect; patient oriented; programs; psychoeducation; psychologic; psychosocial; research study; skills; skills training; social; treatment as usual; trial comparing

DESCRIPTION (provided by candidate): This grant application is for the Mentored Patient-Oriented Career Development (K23) Award. The objective of this award is to promote the candidate's long-term goal of conducting clinical trials of psychosocial interventions for adolescents with mood disorders, especially bipolar disorder, and to study the impact of these treatments on adolescent's symptomatic and psychosocial functioning. Developing effective psychosocial treatments for bipolar youth is an important priority. Current treatment guidelines by the American Academy of Child and Adolescent Psychiatry specify that adjunctive psychosocial therapies are almost always indicated in the treatment of bipolar disorder during adolescence. However, at this time, there are no empirically validated psychosocial treatments for bipolar youth. The career development activities described in this application will develop the candidate's knowledge and skills in 1) the diagnosis, psychosocial treatment, and accurate assessment of symptomatic and psychosocial functioning in adolescents with bipolar disorder; 2) the developmental factors that influence the etiology and clinical course of mood disorders during adolescence; 3) strategies to successfully engage mood disordered adolescents in multi-session psychosocial treatments; and 4) the reciprocal relationship between psychosocial factors and symptomatic functioning in bipolar youth. The research study will be comprised of 2 phases. Phase I is designed to integrate developmentally informed psychological, behavioral, and practical strategies into Interpersonal and Social Rhythm Therapy (IPSRT), an empirically supported psychosocial treatment for adults with bipolar disorder, to enhance the treatment of bipolar adolescents. This process will grow from mentored supervision from experts in the field of child/adolescent psychiatry, developmental psychopathology, and clinical intervention research. In addition, the candidate and project therapist will undertake the treatment of 10 pilot cases of bipolar adolescents. The second phase of the research plan consists of a small, preliminary, randomized trial comparing IPSRT-A to treatment as usual in a sample of adolescents with bipolar disorder. Subjects will be assessed at baseline, monthly during treatment, and 6- month follow-up. The skills, training, and pilot data obtained from this award will support the candidate's development of an R01 application in Years 03-05 of the award period.

描述（由候选人提供）：此赠款申请是针对受过指导的以患者为导向的职业发展（K23）奖的。该奖项的目的是促进候选人的长期目标，即对患有情绪障碍的青少年（尤其是双相情感障碍）进行心理心理干预的临床试验，并研究这些治疗对青少年症状和心理社会功能的影响。为躁郁症青年开发有效的社会心理治疗是重要的重点。美国儿童和青少年精神病学会的当前治疗指南指出，在青春期期间，辅助的心理社会疗法几乎总是在躁郁症的治疗中表明。但是，目前尚无经验验证的躁郁症青少年的社会心理治疗。本申请中描述的职业发展活动将在1）诊断，社会心理治疗以及对双相情感障碍青少年的症状和社会心理功能的准确评估中发展候选人的知识和技能； 2）影响青春期情绪障碍的病因和临床过程的发育因素； 3）成功吸引情绪失调的青少年的策略 多运动的社会心理治疗； 4）躁郁症青年的心理因素与有症状功能之间的相互关系。研究研究将由2个阶段组成。第一阶段旨在将发展知情的心理，行为和实际策略整合到人际和社会节奏疗法（IPSRT）中，这是一种对双相情感障碍成年人的经验支持的心理社会治疗，以增强双相情感青少年的治疗。这一过程将从来自儿童/青少年精神病学，发育心理病理学和临床干预研究领域的专家的指导监督中发展。此外，候选人和项目治疗师将对10例双极青少年进行治疗。研究计划的第二阶段是一个小的，初步的随机试验，该试验将IPSRT-A与往常治疗进行比较，在双相情感障碍的青少年样本中。受试者将在基线，治疗期间每月进行评估，并进行6个月的随访。从该奖项获得的技能，培训和试点数据将支持候选人在奖励期03-05年内开发R01申请。