Adjunctive Psychotherapy for Teens with Bipolar Disorder

双相情感障碍青少年的辅助心理治疗

• 批准号: 7046118
• 负责人: STEFANIE A HLASTALA
• 金额: $ 13.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7046118
• 关键词: adolescence (12-20); behavior modification; behavioral /social science research tag; bipolar depression; child mental disorders; clinical research; clinical trials; dyadic interaction; family structure /dynamics; functional ability; handbook; human subject; human therapy evaluation; lifestyle; mental disorder diagnosis; pathologic process; patient oriented research; psychological adaptation; psychological tests; psychopathology; psychosocial rehabilitation; psychotherapy; social integration; therapy design /development; videotape /videodisc

DESCRIPTION (provided by candidate): This grant application is for the Mentored Patient-Oriented Career Development (K23) Award. The objective of this award is to promote the candidate's long-term goal of conducting clinical trials of psychosocial interventions for adolescents with mood disorders, especially bipolar disorder, and to study the impact of these treatments on adolescent's symptomatic and psychosocial functioning. Developing effective psychosocial treatments for bipolar youth is an important priority. Current treatment guidelines by the American Academy of Child and Adolescent Psychiatry specify that adjunctive psychosocial therapies are almost always indicated in the treatment of bipolar disorder during adolescence. However, at this time, there are no empirically validated psychosocial treatments for bipolar youth. The career development activities described in this application will develop the candidate's knowledge and skills in 1) the diagnosis, psychosocial treatment, and accurate assessment of symptomatic and psychosocial functioning in adolescents with bipolar disorder; 2) the developmental factors that influence the etiology and clinical course of mood disorders during adolescence; 3) strategies to successfully engage mood disordered adolescents in multi-session psychosocial treatments; and 4) the reciprocal relationship between psychosocial factors and symptomatic functioning in bipolar youth. The research study will be comprised of 2 phases. Phase I is designed to integrate developmentally informed psychological, behavioral, and practical strategies into Interpersonal and Social Rhythm Therapy (IPSRT), an empirically supported psychosocial treatment for adults with bipolar disorder, to enhance the treatment of bipolar adolescents. This process will grow from mentored supervision from experts in the field of child/adolescent psychiatry, developmental psychopathology, and clinical intervention research. In addition, the candidate and project therapist will undertake the treatment of 10 pilot cases of bipolar adolescents. The second phase of the research plan consists of a small, preliminary, randomized trial comparing IPSRT-A to treatment as usual in a sample of adolescents with bipolar disorder. Subjects will be assessed at baseline, monthly during treatment, and 6- month follow-up. The skills, training, and pilot data obtained from this award will support the candidate's development of an R01 application in Years 03-05 of the award period.

描述（由候选人提供）：此补助金申请用于指导以患者为导向的职业发展 (K23) 奖。该奖项的目的是促进候选人的长期目标，即对患有情绪障碍，特别是双相情感障碍的青少年进行心理社会干预临床试验，并研究这些治疗对青少年症状和心理社会功能的影响。为躁郁症青少年开发有效的社会心理治疗方法是一个重要的优先事项。美国儿童和青少年精神病学学会当前的治疗指南明确指出，在青春期双相情感障碍的治疗中几乎总是需要辅助心理社会治疗。然而，目前还没有针对双相情感障碍青少年的经经验验证的心理社会治疗方法。本申请中描述的职业发展活动将培养候选人在以下方面的知识和技能：1）双相情感障碍青少年的诊断、心理社会治疗以及症状和心理社会功能的准确评估； 2）影响青春期情绪障碍病因和临床过程的发育因素； 3）成功让情绪障碍青少年参与的策略 多次心理社会治疗； 4）双相情感障碍青少年的心理社会因素与症状功能之间的相互关系。该研究将分为两个阶段。第一阶段旨在将发展性的心理、行为和实践策略整合到人际和社会节律治疗（IPSRT）中，这是一种针对成人双相情感障碍的经验支持的心理社会治疗，以加强对双相情感障碍青少年的治疗。这一过程将在儿童/青少年精神病学、发展精神病理学和临床干预研究领域专家的指导监督下发展。此外，候选人和项目治疗师将承担10个双向情感障碍青少年试点病例的治疗。研究计划的第二阶段包括一项小型、初步、随机试验，在双相情感障碍青少年样本中比较 IPSRT-A 与常规治疗。受试者将在基线、治疗期间每月以及 6 个月随访时接受评估。从该奖项获得的技能、培训和试点数据将支持候选人在奖项期间的第 03-05 年开发 R01 应用程序。