GROWTH HORMONE AND INSULIN RESISTANCE IN CHILDREN WITH INTRAUTERINE GROWTH REST

宫内生长休止儿童的生长激素和胰岛素抵抗

• 批准号: 7607121
• 负责人: Lynne L. Levitsky
• 金额: $ 0.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607121
• 关键词: Body Composition; Child; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Fatty acid glycerol esters; Fetal Growth; Funding; Grant; Institution; Insulin Resistance; Lead; Low Birth Weight Infant; Magnetic Resonance Imaging; Measures; Muscle; Research; Research Personnel; Resources; Rest; Safety; Somatotropin; Source; United States National Institutes of Health; hormone therapy; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance (IR) is associated with special stores of fat in muscle which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, the effect of GH on muscle fat stores will be examined in children who are short due to low birthweight before and after receiving GH therapy. Assessments include MRI analysis of muscle fat, insulin sensitivity, and body composition. Our studies are intended to determine how GH causes IR and may lead to ways to increase its safety and effectiveness.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 胰岛素抵抗（IR）与可以通过MRI测量的肌肉中脂肪的特殊储存。 生长激素（GH）治疗也可能导致IR。 在这项研究中，将在接受GH疗法前后出生的儿童中检查GH对肌肉脂肪储存的影响。 评估包括对肌肉脂肪的MRI分析，胰岛素敏感性和身体组成。 我们的研究旨在确定GH如何引起IR，并可能导致提高其安全性和有效性的方法。