2020 Cornea and Ocular Surface Biology and Pathology GRC/GRS

2020年角膜和眼表面生物学与病理学GRC/GRS

基本信息

批准号：
9913789
负责人：
Alexander V Ljubimov
金额：
$ 3.9万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2020-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913789
关键词：
Affect Atmosphere Awareness Basic Science Biology Blindness Cell Communication Cells Clinic Clinical Research Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Cornea Corneal Diseases Corneal dystrophy Data Discipline Disease Drug Delivery Systems Education Ensure Environment Ethical Issues Eye Feedback Film Fostering Foundations Fund Raising Funding Future Gender Generations Gland Goals Health Homeostasis Immunity Inflammation Inherited Injury International Italy Knowledge Lacrimal gland structure Learning Link Manuscripts Mentors Participant Pathology Pathway interactions Postdoctoral Fellow Proteomics Regulation Renaissance Request for Proposals Research Research Personnel Savings Scholarship Science Scientist Senior Scientist Site Students Testing Time Tissues Translating Transplantation Underrepresented Minority Update Viral Vector Virus Vision Vision research Visual Fields Visual impairment Woman Work aging population bench to bedside career cell type conjunctiva cost drug discovery drug testing exosome experience graduate student improved innovation meetings meibomian gland microbiome microbiota nanomedicine next generation novel novel strategies novel therapeutics ocular surface personalized medicine posters prevent programs social media stem cells success supportive environment symposium therapeutic development therapeutic gene transcriptome translational scientist treatment strategy unpublished works

项目摘要

Project Summary Vision depends on the integrity and functionality of ocular surface comprising cornea, conjunctiva, associated glands and tear film. Alteration of this integrated unit can result in visual impairment or blindness across the developed and developing world. Understanding the fundamentals of ocular surface homeostasis and disease together with innovative therapeutic developments is vital for the health of aging population and the economy. We seek support for a meeting of world leaders in vision research at the 2020 Gordon Research Conference on Cornea & Ocular Surface Biology & Pathology (GRC-COSBP), February 16-21 2020, the Renaissance Tuscany Il Ciocco, Lucca, Italy. Building on the success of previous GRC-COSBP we plan 9 scientific sessions on key paradigm shifting innovations in ocular surface biology and pathology. Sessions will comprise main 20-minute talks with 1-2 short talks invited from poster presentations and focused on young investigators to enable them to present their findings to the community. The session titles are: 1. Intrinsic microbiome and influences of microbiota from remote sites; 2. Exosomes in healthy and diseased ocular surface; 3. CRISPR/personalized medicine – therapeutic gene editing in corneal dystrophies; 4. Identification and generation of corneal stem cells and their use for transplantation; 5. Transcriptome and proteomics: corneal cell types and changes in disease; 6. Corneal neighbors affecting its function: conjunctiva, meibomian and lacrimal glands; 7. From discovery to clinic: drug testing and regulatory issues; 8. Advances in ocular surface drug delivery: viruses vs. nanoconstructs; and 9. Inflammation and immunity in ocular surface diseases. Early career scientists paired with established researchers will co-moderate the sessions. We are inviting a diverse, gender-balanced selection of 36 speakers focusing their talks on their unpublished data. Speakers include junior scientists and some outside of the vision field whose important studies have parallels and application to eye research. The inclusion of speakers outside of the eye field will foster discussions and collaborative opportunities across disciplines and between young investigators and leaders in the field. We request that speakers stay for the GRC duration. We will also hold 4th two-day Gordon Research Seminar (GRS) for graduate students and postdocs working in the ocular surface field immediately before GRC-COSBP. GRS facilitates interactions and opportunities for early career scientists to present data in a relaxed atmosphere and gain experience in conference organization and chairing sessions. Previous GRS participants have continued active participation in the GRC and we fully expect this to be the case in 2020. 2020 GRS and GRC-COSBP will continue the tradition of supporting future field leaders to interact with each other at the GRS and with established scientists at the GRC. The formed relationships are likely to last and be productive for many years. We encourage underrepresented minorities to attend GRC and GRS through GRC scholarships. We will keep the community aware of this GRC and program updates via social media. NEI support will greatly ensure the program quality and the ultimate success of the 2020 GRC-COSBP.

项目概要视力取决于眼表的完整性和功能性，包括角膜、结膜、相关组织等。腺体和泪膜的改变会导致视力障碍或失明。了解眼表稳态和疾病的基础知识。创新疗法的发展对于老龄化人口的健康和经济至关重要。我们寻求支持在 2020 年戈登研究会议上召开世界视觉研究领导人会议角膜和眼表生物学与病理学 (GRC-COSBP)，2020 年 2 月 16 日至 21 日，托斯卡纳文艺复兴酒店 Il Ciocco，卢卡，意大利在之前 GRC-COSBP 成功的基础上，我们计划举办 9 场关键的科学会议。眼表生物学和病理学的范式转变创新将包括 20 分钟的主要会议。由海报展示邀请的 1-2 场简短演讲，重点关注年轻研究者，使他们能够向社区展示他们的研究结果。会议标题是：1.内在微生物组及其影响。 2. 健康和患病眼表的微生物群；3. CRISPR/个性化医学——角膜营养不良的治疗性基因编辑；4.角膜干细胞的鉴定和生成；及其在移植中的应用； 5. 转录组和蛋白质组学：角膜细胞类型和疾病变化； 6. 影响其功能的角膜邻居：结膜、睑板腺和泪腺； 7. 从发现到临床：药物测试和监管问题；8.眼表药物输送的进展：病毒与纳米结构； 9. 眼表疾病中的炎症和免疫。研究人员将共同主持这些会议，我们邀请了 36 名多元化、性别平衡的演讲者。演讲者的演讲重点是未发表的数据，其中包括初级科学家和一些愿景之外的人。其重要研究与眼睛研究有相似之处和应用。眼领域的研究将促进跨学科和年轻人之间的讨论和合作机会我们要求发言人在 GRC 期间留下来。我们也将举行第四次会议。为期两天的戈登研究研讨会 (GRS)，面向从事眼表工作的研究生和博士后 GRS 之前的领域促进了早期职业科学家的互动和机会。在轻松的氛围中展示数据并获得会议组织和主持会议的经验。之前的 GRS 参与者继续积极参与 GRC，我们完全预计情况会如此 2020 年。2020 年 GRS 和 GRC-COSBP 将延续支持未来领域领导者与 GRS 中的彼此以及 GRC 中已建立的科学家之间形成的关系可能会持续下去。我们鼓励代表性不足的少数群体通过 GRC 参加 GRC 和 GRS。我们将通过社交媒体支持让社区了解 GRC 和计划的最新情况。将有力保障2020年GRC-COSBP的项目质量和最终成功。