GH AND INSULIN RESISTANCE IN GIRLS WITH TURNER SYNDROME OR ISS

患有特纳综合征或 ISS 的女孩的 GH 和胰岛素抵抗

• 批准号: 7607065
• 负责人: Lynne L. Levitsky
• 金额: $ 0.03万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607065
• 关键词: Affect; Body Composition; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Fatty acid glycerol esters; Funding; Grant; Institution; Insulin Resistance; Lead; Magnetic Resonance Imaging; Measures; Muscle; Research; Research Personnel; Resources; Safety; Somatotropin; Source; Turner' s Syndrome; United States National Institutes of Health; girls; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance (IR) is associated with special stores of fat in muscle, which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, we will determine how GH affects muscle fat stores in girls receiving GH for short stature, both during and without GH treatment. Assessments include analyses of muscle fat by MRI, insulin sensitivity, and body composition. Our studies are intended to help us understand how GH causes IR and may lead to ways to increase its safety and effectiveness.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 胰岛素抵抗（IR）与肌肉中脂肪的特殊储存有关，可以通过MRI测量。生长激素（GH）治疗也可能导致IR。在这项研究中，我们将确定GH在接受GH的女性中如何影响GH的肌肉脂肪储存，无论是在GH治疗期间还是没有GH治疗。评估包括通过MRI对肌肉脂肪的分析，胰岛素敏感性和身体组成。我们的研究旨在帮助我们了解GH是如何引起IR的，并可能导致提高其安全性和有效性的方法。