ROLE OF GHRELIN AND PYY IN POSTPARTUM BODY WEIGHT REGULATION

GHRELIN 和 PYY 在产后体重调节中的作用

• 批准号: 8167815
• 负责人: ENNETTE LARSON-MEYER
• 金额: $ 12.41万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167815
• 关键词: Appetite Regulation; Birth; Blood; Body Composition; Body Weight; Body fat; Breast Feeding; Child; Childbirth; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Development; Enrollment; Fasting; Funding; Grant; Hormones; Human Milk; Infant; Institution; Measurement; Metabolism; Obesity; Overweight; Postpartum Period; Regulation; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Source; United States National Institutes of Health; Woman; child bearing; ghrelin; polypeptide; pregnant; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Large scale studies have suggested that childbearing is an important contributor to the development of obesity in many women, and that breastfeeding may be protective against risk of overweight or obesity in the mom and in the infant. It is possible that ghrelin and polypeptide YY (PYY), two recently discovered gut hormones involved in appetite regulation, are altered after child birth and with breastfeeding and are associated with body weight/body fat retention (or loss) after childbirth. It is also plausible that ghrelin and PYY are present in human milk where they may regulate appetite in the breastfed infant. The specific aims of this project are to: 1) determine whether fasting or meal-induced blood levels of these appetite regulating hormones differ between breastfeeding, non-breastfeeding and non-pregnant controls; 2) assess whether these hormones are involved in body weight regulation after childbirth; and 3) determine whether breast milk contains these two hormones. The study will enroll 15-20 breastfeeding women and 15-20 non-breastfeeding women four weeks after delivery; and 15-20 -never pregnant controls. Volunteers will have measurements of their body weight, body composition and resting metabolism, as well as their ghrelin and PYY responses to a standardized breakfast meal. Volunteers' body weight and body composition will be followed for 1 year after delivery. The breastfeeding women will also provide samples of breast milk for analysis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 大规模研究表明，生育是许多妇女肥胖发展的重要贡献，并且母乳喂养可能可以防止妈妈和婴儿中超重或肥胖的风险。生长素和多肽YY（PYY）可能是最近发现的两种参与食欲调节的肠道激素，在儿童出生和母乳喂养后会改变，并与分娩后的体重/体重/体重/体重/体重/体重/体重脂肪（或损失）有关。生长素和PYY存在于人类牛奶中，它们可以调节母乳喂养婴儿的食欲，这也是合理的。该项目的具体目的是：1）确定在母乳喂养，非胸外喂养和非妊娠控制剂之间，这些食欲的禁食或进餐引起的血液水平是否有所不同； 2）评估这些激素是否参与分娩后体重调节； 3）确定母乳是否含有这两种激素。该研究将在分娩后四个星期招收15-20名母乳喂养妇女和15-20名非胸外喂养妇女；和15-20-永不怀孕的对照。志愿者将测量其体重，身体成分和静息代谢，以及对标准化早餐餐的生长素和PYY反应。分娩后将遵循志愿者的体重和身体成分。母乳喂养的妇女还将提供母乳样本进行分析。