EPIDEMIOLOGY OF SLEEP-DISORDERED BREATHING

睡眠呼吸障碍的流行病学

• 批准号: 7607562
• 负责人: TERRY B Young
• 金额: $ 2.48万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607562
• 关键词: Address; Adult; Age; Cardiovascular system; Cerebrovascular Disorders; Chronic; Clinical; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Diagnosis; Enrollment; Epidemiology; Functional disorder; Funding; Grant; Health; Hypersomnolence; Hypertension; Individual; Injury; Institution; Mental Depression; Minority; Morbidity - disease rate; Occupational; Outcome; Participant; Prevention; Public Health; Quality of life; Recruitment Activity; Research; Research Personnel; Resources; Risk; Role; Sampling; Sleep; Sleep Apnea Syndromes; Source; Stroke; Time; United States National Institutes of Health; Wisconsin; Woman; cognitive function; men; middle age; mortality; pre-clinical; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [[from CRISP website (edited)] Sleep disordered breathing (SDB), is a widespread but under-diagnosed condition that may have a role in causing hypertension, cardiovascular, and cerebrovascular disease, hypersomnolence, and lower daytime functioning. However, findings thus far are not enough for determining rational clinical and public health responses. The long-term objective of this project is to determine how much morbidity and mortality from SDB could potentially be reduced with prevention or treatment of SDB. Because SDB is a chronic and severe condition and the health effects may take years to develop, samples over a period of time are essential. Also, SDB is high in middle age, but the long-term outcomes are conditions primarily occuring in older age (>60 years), requiring data on individuals as they move from middle to older age to validly estimate the morbidity risks attributable to SDB. Currently these data are lacking; this research proposed addresses the gap in understanding the burden of undiagnosed SDB in adults. We will investigate the role of SDB in oreclinical cardiovascular and cerebrovascular disease (CVD/stroke), incident CVD/stroke, mortality and in chronic daytime dysfunction. We will also investigate changes in SDB occurrence and its effects with aging from middle to older age. We are doing research on a subsample of 500 men and women who will transition from middle to older age (> 60 years) during the 5 years of the study. All minority participants enrolled in the Wisconsin Sleep Cohort Study (WSCS) will be recruited for both exams, regardless of age. We will assess the independent contribution of SDB to preclinical and overt CVD/stroke, hypersonmolence, cognitive function, occupational injury, depression and quality of life.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 [[来自 CRISP 网站（编辑）] 睡眠呼吸障碍 (SDB) 是一种普遍存在但诊断不足的疾病，可能导致高血压、心血管和脑血管疾病、嗜睡和白天功能下降。然而，迄今为止的发现还不足以确定合理的临床和公共卫生应对措施。 该项目的长期目标是确定通过预防或治疗 SDB 可以将 SDB 的发病率和死亡率降低多少。由于 SDB 是一种慢性且严重的疾病，其对健康的影响可能需要数年时间才能显现，因此一段时间内的样本至关重要。此外，SDB 在中年人群中较高，但长期结果是主要发生在老年（>60 岁）的情况，需要个人从中年向老年的数据来有效估计 SDB 的发病风险。 目前这些数据还缺乏；这项研究旨在解决对成人未确诊 SDB 负担的理解差距。我们将研究 SDB 在临床心脑血管疾病（CVD/中风）、CVD/中风事件、死亡率和慢性日间功能障碍中的作用。我们还将研究 SDB 发生的变化及其随中年老龄化的影响。 我们正在对 500 名男性和女性的子样本进行研究，他们将在 5 年的研究期间从中年过渡到老年（> 60 岁）。所有参加威斯康星州睡眠队列研究 (WSCS) 的少数族裔参与者，无论年龄大小，都将被招募参加这两项考试。 我们将评估 SDB 对临床前和明显的 CVD/中风、过度睡眠、认知功能、职业损伤、抑郁和生活质量的独立贡献。