EPIDEMIOLOGY OF SLEEP-DISORDERED BREATHING IN ADULTS

成人睡眠呼吸障碍的流行病学

• 批准号: 2825127
• 负责人: TERRY B Young
• 金额: $ 89.41万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2825127
• 关键词: blood pressure; clinical research; cognition disorders; depression; disease /disorder etiology; disease /disorder proneness /risk; human middle age (35-64); human morbidity; human old age (65+); human subject; hypertension; longitudinal human study; obesity; pathologic process; polysomnography; racial /ethnic difference; respiratory airflow disorder; respiratory disorder epidemiology; sleep; sleep apnea; sleep disorders; southeast Asian; vehicular accident

The long-term goal of this study is to provide population-based knowledge as a foundation for developing strategies to reduce the occurrence and morbidity of sleep-disordered breathing (SDB). Toward this goal, we propose a longitudinal study of middle-aged adults to characterize the natural history and biologic spectrum of SDB and test hypotheses regarding SDB causes and consequences. Our specific aims, listed below, will be accomplished by conducting follow-up polysomnography and other protocols on an established cohort (n=1400) of men and women, ages 35-70, currently enrolled in the Wisconsin Sleep Cohort Study. The proposed follow-up studies will yield data spanning 5-15 years, with 2-5 data collection points. In addition, we propose to conduct home polysomnography protocols on 200 Hmong adults. Our aims are: 1) Describe with optimal parameters the natural history and biologic spectrum of SDB; 2) Test the role of obesity and other risk factors in the occurrence and progression of SDB; 3) Test the hypothesis that SDB has a causal role in the development and exacerbation of elevated blood pressure and other cardiovascular disease risk factors; 4) Test the hypothesis that SDB causes behavioral morbidity, including extreme daytime sleepiness, cognitive impairment, motor vehicle accidents, and depression. 5) Characterize SDB and other sleep disorders in Hmong, a minority population at high risk for sudden death during sleep.

这项研究的长期目标是提供基于人群的知识，以制定降低睡眠呼吸呼吸的发生和发病率（SDB）的策略的基础。为了实现这一目标，我们提出了一项对中年成年人的纵向研究，以表征SDB的自然历史和生物学谱以及有关SDB原因和后果的测试假设。下面列出的我们的具体目的将通过对目前已在威斯康星州睡眠队列研究中招收的男性和女性进行后续多仪表和其他方案来实现。 提出的后续研究将产生跨越5 - 15年的数据，并提供2-5个数据收集点。 此外，我们建议对200个苗族成年人进行家庭多摄影学方案。 我们的目标是：1）用最佳参数描述SDB的自然历史和生物谱； 2）测试肥胖和其他危险因素在SDB发生和进展中的作用； 3）检验以下假设：SDB在血压升高和其他心血管疾病危险因素的发展和加剧中具有因果关系； 4）检验SDB引起行为发病率的假设，包括极端的白天嗜睡，认知障碍，汽车事故和抑郁症。 5）以苗族的SDB和其他睡眠障碍为特征，在睡眠期间，少数族裔人口高风险。