Epidemiology of Sleep-Disordered Breathing in Adults

成人睡眠呼吸障碍的流行病学

基本信息

批准号：
7652075
负责人：
TERRY B Young
金额：
$ 105.88万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7652075
关键词：
Address Adult Age Age of Onset Age-Years Age-associated memory impairment Aging Alleles Apnea Apolipoprotein E Arts Attention Awareness Biological Markers Birth Blood Vessels Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Carotid Artery Plaques Cerebrovascular Disorders Characteristics Chronic Clinical Cohort Studies Communities Coronary heart disease Data Decision Making Development Diagnosis Disease Dual-Energy X-Ray Absorptiometry Echocardiography Elderly Epidemic Epidemiology Equilibrium Event Frequencies Functional disorder General Population Goals Grant Health Health Policy Health Promotion Heart High Prevalence Hypersomnolence Hypertension Image Impaired cognition Incidence Individual Injury Intervention Knowledge Left Ventricular Mass Longitudinal Studies Measures Memory Monitor Morbid Obesity Morbidity - disease rate Natural History Neuropsychological Tests Obesity Outcome Participant Patients Peer Review Peripheral Resistance Persons Polysomnography Population Population Study Positioning Attribute Prevalence Prevention Protocols documentation Public Health Publications Pulse Pressure Questionnaires Reaction Time Recording of previous events Research Resources Risk Risk Factors Role Sampling Seminal Severities Sleep Sleep Apnea Syndromes Sleep Disorders Sleeplessness Stereotyping Stroke Subgroup Techniques Testing Translations Ultrasonography Vascular Diseases Ventricular Wisconsin Woman World War II age related aged arterial tonometry base case finding clinical application cognitive function cohort demographics design executive function experience falls follow-up hypnotic indexing intima media men middle age mortality pre-clinical premature pressure prevent programs psychosocial public health relevance stressor vigilance

项目摘要

DESCRIPTION (provided by applicant): Sleep disordered breathing (SDB), described by the frequency of apnea and hypopnea events during sleep, is widely recognized as a highly prevalent but under-diagnosed condition that has a significant role in hypertension, cardiovascular and cerebrovascular disease, impaired cognitive function, hypersomnolence, decrements in daytime functioning and premature all-cause and cardiovascular mortality. Population studies over the 20 years have established the high prevalence of SDB and begun to identify the correlates and outcomes of SDB, but critical questions must be addressed to craft clinical and public health policy regarding the prevention and treatment of SDB. Important period effects that will change the SDB burden are occurring in the US, including aging of the large post World War II birth cohort, enhanced survival of older adults who have had different exposures during midlife to SDB risk factors, and an obesity epidemic. Data to address the public health burden of SDB under these new conditions are lacking. The research proposed here is designed to address the gap in understanding the burden of untreated SDB. With a 5-year continuation of the Wisconsin Sleep Cohort Study, a longitudinal study of SDB and other sleep disorders, we will continue to follow a community sample (n= 1522) of men and women, 30-60 years of age at baseline, who will have aged to 55-85 years over the continuation. With data spanning up to 25 years, with individual trajectories of data on SDB and other factors from middle to older age, we will optimally estimate the role of untreated SDB in preclinical and clinically evident cardiovascular and cerebrovascular disease (CVD/stroke), cognitive impairment, and chronic daytime dysfunction. We will also investigate the impact of age-related risk factors on sleep disorders. To achieve these goals, we will conduct follow-up protocols with overnight polysomnography, state of the art body habitus measures including DXA, echocardiography and vascular imaging, neuropsychologic test batteries, and other tests to extend our rich data on SDB status, risk factors, and outcomes. PUBLIC HEALTH RELEVANCE: The finding from the proposed longitudinal Wisconsin Sleep Cohort Study on the occurrence and progression of SDB, in a population transitioning from late middle to older age, and on the role SDB has in the development of morbidity and mortality will contribute needed new knowledge of public health significance. The findings will inform clinical decision making regarding what level of severity of SDB should be identified, whether subgroups should be targeted for case-finding, and decrease inequities due to referral and treatment based on incorrect SDB patient stereotypes. The findings will also inform public health policy regarding needed new resources, public programs designed to set goals to increase awareness of SDB, and to prevent SDB occurrence and progression, and to include SDB in federal health promotion and monitoring programs.

描述（由申请人提供）：睡眠不足的呼吸（SDB），用呼吸暂停和睡眠期间的呼吸道事件描述，被广泛认为是一种高度普遍但未诊断的状况，在高血压，心血管疾病，心血管疾病和脑疾病，障碍性障碍功能，高血压功能，高血压，高体积，欲望和疾病中的疾病中具有重要作用。在过去20年中，人口研究已经确定了SDB的较高流行率，并开始确定SDB的相关性和结果，但是必须解决有关预防和治疗SDB的临床和公共卫生政策的关键问题。在美国，将会改变SDB负担的重要时期影响，包括大型第二次世界大战后出生队列的衰老，在中年生活期间对SDB危险因素有不同暴露的老年人的生存增强，以及肥胖症的流行。在这些新条件下，缺乏解决SDB公共卫生负担的数据。此处提出的研究旨在解决了解未经处理的SDB负担的差距。随着威斯康星州睡眠队列研究的5年延续，对SDB和其他睡眠障碍的纵向研究，我们将继续跟随男性和女性的社区样本（n = 1522），基线为30-60岁，他们将在延长过程中年龄为55-85岁。随着数据的最高25年，随着SDB和其他年龄较大的其他因素的单个数据轨迹，我们将最佳地估计未经处理的SDB在临床前和临床上明显的心血管疾病和脑血管疾病（CVD/Stroke）（CVD/Stoke），认知障碍，以及慢性日期失调的作用。我们还将研究与年龄相关的危险因素对睡眠障碍的影响。为了实现这些目标，我们将使用隔夜多渗透学，最先进的身体习惯措施，包括DXA，超声心动图和血管成像，神经心理测试电池以及其他测试，以扩展我们对SDB状态，风险因素和目的的丰富数据，以扩展我们丰富的数据。公共卫生相关性：从拟议的威斯康星州纵向睡眠队列研究中，关于SDB发生和进展的纵向睡眠队列研究，从中期到年龄较大的人口中以及SDB在发病率和死亡率发展中的作用中，需要有助于新的公共健康意义知识。这些发现将为应识别SDB严重程度的临床决策提供依据，是否应针对调查病例调查，以及基于不正确的SDB患者刻板印象而引起的不平等和治疗引起的不平等。这些发现还将为公共卫生政策提供有关所需新资源的公共卫生政策，旨在设定目标以提高SDB认识以及防止SDB发生和进步的公共计划，并将SDB包括在联邦健康促进和监测计划中。