RELATIONS BETWEEN URINE AND SERUM MEASURES OF IRON STATUS

尿液和血清铁状态测量之间的关系

• 批准号: 7607481
• 负责人: RICHARD M ALLEN
• 金额: $ 0.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607481
• 关键词: Age; Computer Retrieval of Information on Scientific Projects Database; Data; Etiology; Excretory function; Funding; Gender; Grant; Hour; Institution; Iron; Measures; Numbers; Race; Relative (related person); Research; Research Personnel; Resources; Restless Legs Syndrome; Serum; Source; Time; United States National Institutes of Health; Urine; iron metabolism; receptor; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). In a parallel study, these investigators are characterizing the mechanism of the relative iron deficiency observed in RLS and preliminary data implicate increased iron excretion as the etiology for reduced iron stores and the inability to maintain these stores. Preliminary data showed an unexpectedly strong relationship between 24 hour urinary iron excretion and night time transferring receptor (TfR) numbers. To confirm and better characterize the presumed inverse logarithmic relationship between iron excretion and serum TfR in normal controls, these investigators propose a descriptive study to analyze the 24 hour urine iron and serum TfR levels in 28 age, gender, and race-matched controls. These data will be used to establish the parameters of normal iron excretion and will be compared with the iron excretion observed in RLS subjects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这些研究人员已经证明，不宁腿综合征 (RLS) 受试者的铁代谢存在差异。在一项平行研究中，这些研究人员正在描述 RLS 中观察到的相对铁缺乏的机制，初步数据表明铁排泄增加是铁储存减少和无法维持这些储存的病因。初步数据显示，24 小时尿铁排泄量与夜间转移受体 (TfR) 数量之间存在出乎意料的密切关系。 为了证实并更好地表征正常对照中铁排泄与血清 TfR 之间假定的反对数关系，这些研究人员提出了一项描述性研究，分析 28 名年龄、性别和种族匹配对照的 24 小时尿铁和血清 TfR 水平。这些数据将用于建立正常铁排泄的参数，并将与 RLS 受试者中观察到的铁排泄进行比较。