NEUROBEHAVIORAL FEATURES OF MESIAL TEMPORAL LOBE EPILEPSY

内侧颞叶癫痫的神经行为特征

• 批准号: 7607500
• 负责人: Bruce Phillip Hermann
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607500
• 关键词: Adverse effects; Age; Brain; Chronic; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Epilepsy; Face; Functional Magnetic Resonance Imaging; Funding; Gender; Grant; Impaired cognition; Institution; Investigation; Language; Magnetic Resonance Imaging; Measures; Medical; Memory; Mental Depression; Neurobiology; Process; Purpose; Research; Research Personnel; Resolution; Resources; Source; Speed; Structure; Temporal Lobe; Temporal Lobe Epilepsy; Testing; Time; United States National Institutes of Health; base; brain tissue; design; early onset; neurobehavioral; neuropsychological; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from CRISP website) We are proposing the first prospective investigation designed to detect progressive adverse effects of chronic early onset (less than age 14) temporal lobe epilepsy (TLE) on brain structure and function. This proposed study will combine high- resolution quantitative MRI volumetrics, comprehensive neuropsychological assessment, and an fMRI memory activation task. The purpose of this investigation is to test the hypothesis that early onset TLE is associated with a generalized adverse neurodevelopmental impact on both brain structure and function. If this is proven, that may constitute an early-acquired neurobiological vulnerability for progressive cognitive decline in the face of ongoing chronic epilepsy. We will do a longitudinal examination of 80 early onset TLE subjects and 80 age and gender matched controls that were initially seen for baseline testing four to five years earlier. All subjects will again undergo cognitive assessment and whole brain quantitative MRI volumetrics and a subset of subjects will undergo an fMRI object memory task. It is predicted that: (1) cognitive decline in this four-five year interval will be greater for early onset TLE subjects compared to controls, (2) decline will be most evident among those with longer duration of epilepsy, and for measures of memory function, speeded cognitive processing and non-verbal abilities compared to language based tasks, (3) test-retest cognitive decline shown by early onset TLE subjects will be predicted by time total brain tissue volume and proportional brain tissue lost over the test- retest interval, and (4) increasing chronicity of epilepsy will be associated with decreasing mesial temporal lobe activation on an fMRI object memory task. Additional analyses will examine the impact of specific epilepsy course variables, depression, and associated chronic medical illness on longitudinal changes in TLE.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 （来自Crisp网站） 我们提出了第一次旨在检测慢性早期发作（小于14岁）颞叶癫痫（TLE）对大脑结构和功能的渐进性不良反应的前瞻性研究。这项提出的研究将结合高分辨率定量MRI体积，全面的神经心理学评估和fMRI记忆激活任务。这项研究的目的是检验以下假设：早期发作与对大脑结构和功能的普遍不良神经发育影响有关。 如果证明这一点，这可能构成了面对持续的慢性癫痫的早期认知下降的早期神经生物学脆弱性。我们将对80名早期受试者和80岁的年龄以及性别匹配的控制措施进行纵向检查，这些对照最初是四到五年前的基线测试。所有受试者都将再次接受认知评估和整个大脑定量MRI体积，一部分受试者将执行fMRI对象记忆任务。 可以预料的是，（1）与对照组相比，早期发作的受试者的认知能力下降将更大，（2）在癫痫病持续时间更长的人中，下降最明显，对于记忆功能持续时间较长，衡量标准的措施，与语言的范围相比，通过（3）测试量的预测量相比，（3）速度降低了，（3）速度降低的能力，（3）预测量的预测量，（3）（3）测试量的预期范围（3）（3）（3）（3）（3）（3）（3）（3）（3）（3）（3）。比例的脑组织在重新测试间隔中丢失，并且（4）癫痫的慢性增加将与fMRI对象记忆任务上的介体颞叶激活减少有关。 其他分析将检查特定的癫痫病程变量，抑郁症和相关的慢性医学疾病对TLE纵向变化的影响。