Neuropsychological Progression in New Onset Epilepsy

新发癫痫的神经心理学进展

• 批准号: 8438586
• 负责人: Bruce Phillip Hermann
• 金额: $ 59.89万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8438586
• 关键词: Adolescent; Adult; Affect; Age; Anatomy; Area; Benign; Brain; Child; Childhood; Clinical; Cognition; Cognition Disorders; Cognitive; Cohort Studies; Comorbidity; Development; Diagnosis; Employment; Epilepsy; Evolution; Exhibits; Family; Family history of; Funding; Image; Independent Living; Investigation; Life; Life Cycle Stages; Longevity; Marriage and Family; Medical; Modeling; Natural History; Nature; Neurobehavioral Manifestations; Newly Diagnosed; Outcome; Participant; Performance; Procedures; Psychiatric Diagnosis; Recording of previous events; Risk; Risk Factors; Rolandic Epilepsy; Role; Sample Size; Shapes; Structure; Syndrome; Techniques; Testing; Time; Work; adverse outcome; brain volume; cohort; insight; nervous system disorder; neural circuit; neurobehavioral; neuroimaging; neuropsychological; proband; prospective; social; white matter; young adult

DESCRIPTION (provided by applicant): Cognitive, academic, social and psychiatric abnormalities are common in childhood onset epilepsy, with enduring adverse consequences into adulthood, even among those with uncomplicated and remitted epilepsies. To understand the natural history of these lifespan issues, the initial funding cycle of our prospective cohort study (RO1-44351) examined children (ages 8-18) with newly diagnosed idiopathic epilepsies (n=75) and healthy controls (n=62), and followed them for 2 years with neuropsychological, psychiatric, and neuroimaging techniques. While informing the early natural history of cognitive, anatomic, and psychiatric abnormalities of childhood epilepsy, we also identified risk factors at the time of epilepsy diagnosis that predicted developmental trajectories two years following diagnosis. We hypothesize these same abnormalities will predict longer term outcomes in important areas of life performance (e.g., employment, independent living, educational attainment). In this competing renewal application, we propose to follow our original cohort to characterize and predict young adulthood outcomes, enrich the cohort with new onset epilepsy and control participants (n=150), and incorporate new procedures to test hypotheses regarding the effects of family history, disrupted neural circuitry, and epilepsy syndrome on life course. The specific aims of this competing renewal application are as follows: 1) Characterize the longer-term (10- year) social, educational, vocational, and psychiatric trajectories of childhood onset epilepsy and identify predictors of favorable and unfavorable young adult outcomes; 2) Clarify the role of family history to the presence of cognitive and psychiatric comorbidities in children with new onset epilepsy; 3) Characterize the relationship between abnormalities in brain volume, shape and connectivity with disordered cognition and psychiatric status; and 4) Identify syndrome-specific cognitive, psychiatric, and imaging abnormalities. PUBLIC HEALTH RELEVANCE: Childhood epilepsy is a prevalent neurological disorder associated with poor outcomes in key aspects of adult life (e.g., employment and finances; marriage and family; social and psychiatric status), but the predictors of these outcomes remain poorly understood. The results of this controlled prospective cohort investigation will provide what we believe are the earliest insights into the natural history of these problematic lifespan outcomes.

描述（由申请人提供）：认知，学术，社会和精神病异常在儿童时期癫痫病很常见，即使是成年后的持久后果，即使是那些具有简单和恢复癫痫病的人。为了了解这些寿命问题的自然历史，我们的前瞻性队列研究（RO1-44351）的最初资助周期检查了新诊断的特发性癫痫（n = 75）和健康对照（n = 62）的儿童（8-18岁）（n = 62），随后进行了2年的神经心理心理学，心理学，精神，Neuesiquick和Neureciquicagengic。在告知儿童癫痫的认知，解剖和精神病异常的早期自然史的同时，我们还确定了癫痫诊断时的危险因素，这些危险因素预测了诊断后两年的发育轨迹。我们假设这些相同的异常将预测生活表现重要领域的长期结局（例如，就业，独立生活，教育程度）。在此竞争性续约应用中，我们建议遵循我们的原始队列来表征和预测年轻成年后的结果，以新的发作癫痫和对照参与者（n = 150）丰富该同类群体，并结合了有关家庭历史的影响的新程序，以进行家庭历史的影响，神经循环中断，epilepsy consects on Life cyndre cyndre cyndre cyndre cyndre cyndre cyndre consents consent。这种竞争性更新应用的具体目的如下：1）表征童年发作性癫痫的长期（10年）社会，教育，职业和精神病学轨迹，并确定有利和不利的年轻成人成年结果的预测因素； 2）阐明家族史对具有新发作癫痫的儿童的认知和精神病合并症的作用； 3）表征大脑体积，形状和连通性异常与认知和精神病状态无序的关系； 4）确定综合征特异性的认知，精神病和成像异常。 公共卫生相关性：儿童癫痫是一种普遍的神经系统疾病，与成人生活的关键方面（例如，就业和财务状况；婚姻与家庭；社会和精神病地位）相关的不良结果相关，但这些结果的预测因素仍然很众所周知。这项受控的前瞻性队列调查的结果将提供我们认为是对这些有问题的寿命结果自然历史的最早见解。