NEUROPSYCHOLOGICAL PROGESSION IN NEW ONSET EPILEPSY

新发癫痫的神经心理学进展

• 批准号: 7955700
• 负责人: Bruce Phillip Hermann
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955700
• 关键词: Adult; Age; Brain; Cerebrum; Characteristics; Child; Childhood; Chronic; Clinical; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Diffusion Magnetic Resonance Imaging; Epilepsy; Etiology; Exhibits; Frequencies; Funding; Gender; Grant; Growth; Image; Impaired cognition; Institution; Investigation; Magnetic Resonance Imaging; Modeling; Morbidity - disease rate; Partial Epilepsies; Recording of previous events; Research; Research Personnel; Resources; Seizures; Severities; Source; Structure; Temporal Lobe Epilepsy; Time; United States National Institutes of Health; brain tissue; cognitive function; computational anatomy; longitudinal design; neuroimaging; neuropsychological; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our prior investigation of adults with chronic localization-related (temporal lobe) epilepsy and healthy controls has shown childhood onset epilepsy to be associated with a generalized adverse neurodevelopmental impact on brain structure and cognitive function (NS-37738). The purpose of this proposal is to directly characterize the timing, cause and consequences of this adverse neurodevelopmental impact. Using a combined cross-sectional and longitudinal design, 75 children (age 8-18) with new onset localization-related epilepsy will be compared to 75 age and gender matched controls. Cross-sectional and two-year longitudinal assessment of neuropsychological status and neuroimaging (quantitative MRI, diffusion tensor imaging, and magnetization transfer imaging) will be integrated with information regarding neurodevelopmental history, clinical epilepsy characteristics and psychiatric morbidity in order to clarify the timing, etiology and consequences of evident abnormalities in brain structure and cognition. We hypothesize the following: (1) children with new onset localization-related epilepsy will exhibit generalized cognitive impairment, generalized reduction in total brain tissue volumes (especially cerebral white matter volumes), and microstructural abnormalities in cerebral white matter compared to controls, (2) frequency of preexisting neurodevelopmental abnormalities will be significantly increased in children with new onset epilepsy compared to controls and will be associated with neuroimaging and cognitive abnormalities at epilepsy onset, (3) ongoing childhood onset epilepsy will be associated with lags in normal cognitive and brain development (especially cerebral white matter) and increased psychiatric morbidity compared to controls, and (4) earlier age of epilepsy onset will be the strongest predictor of lags in brain growth and cognitive development while seizure severity will be most strongly associated with increased psychiatric morbidity.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们先前对具有慢性定位相关（颞叶）癫痫和健康对照的成年人的研究表明，童年发作性癫痫与对脑结构和认知功能的一般性不良神经发育影响有关（NS-377738）。该提案的目的是直接表征这种不良神经发育影响的时间，原因和后果。使用横截面和纵向设计组合，将有75名具有新发作定位相关癫痫的儿童（8-18岁）与75岁和性别匹配的对照组相比。 Cross-sectional and two-year longitudinal assessment of neuropsychological status and neuroimaging (quantitative MRI, diffusion tensor imaging, and magnetization transfer imaging) will be integrated with information regarding neurodevelopmental history, clinical epilepsy characteristics and psychiatric morbidity in order to clarify the timing, etiology and consequences of evident abnormalities in brain structure and cognition.我们假设以下情况：（1）具有新发作定位相关癫痫的儿童将表现出普遍的认知障碍，总脑组织大容量的全面减少（尤其是脑白质体积）（尤其是脑白质体积），以及与对照组相比，脑白质的频率与新生素的频率相比，（2）具有较大的abnositive的频率，是（2）均具有新生素的频率，（2）与对照组相比癫痫病，将与癫痫发作时的神经影像和认知异常有关，（3）持续的儿童期癫痫将与正常的认知和脑发育中的滞后（尤其是脑白质）（尤其是脑白质）中的滞后以及与对照组相比，（4）与对照组相比，ePilepsys的增长年龄越来越强，脑发育率的增长是epilepsys的增长年龄。尽管癫痫发作的严重程度将与增加的精神病发病率最密切相关。