ENDOTHELIAL DYSFUNCTION IN TERM AND NEAR-TERM NEONATES WITH PULMONARY HYPERTENS

患有肺动脉高压的足月和近足月新生儿的内皮功能障碍

• 批准号: 7606488
• 负责人: Scott C. Denne
• 金额: $ 0.72万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606488
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; Infant; Institution; Knowledge; Lung; Morbidity - disease rate; Persistent Fetal Circulation Syndrome; Play; Purpose; Research; Research Personnel; Resources; Role; Source; Techniques; United States National Institutes of Health; experience; mortality; neonatal pulmonary hypertension; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent pulmonary hypertension of the newborn (PPHN) is an important cause of morbidity and mortality in term and near-term infants. There is accumulating evidence, largely from animal studies, that abnormalities of endothelial function may play a role in PPHN. To our knowledge, there is no information specifically assessing endothelial function in neonates who have experienced PPHN. The purpose of this study is to provide preliminary information about possible endothelial dysfunction in PPHN using a noninvasive technique.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 新生儿持续性肺动脉高压（PPHN）是足月儿和近足月儿发病和死亡的重要原因。 越来越多的证据（主要来自动物研究）表明，内皮功能异常可能在 PPHN 中发挥作用。 据我们所知，没有专门评估经历过 PPHN 的新生儿内皮功能的信息。 本研究的目的是使用无创技术提供有关 PPHN 中可能的内皮功能障碍的初步信息。