METABOLIC CONSEQUENCES OF GROWTH FAILURE IN EXTREMELY LOW BIRTH WEIGHT INFANTS

极低出生体重婴儿生长障碍的代谢后果

• 批准号: 7379175
• 负责人: Scott C. Denne
• 金额: $ 4.35万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379175
• 关键词: METABOLIC; CONSEQUENCES; GROWTH; FAILURE; EXTREMELY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite continually improving survival rates, growth outcomes for premature extremely low birth weight (ELBW) infants remains exceptionally poor. Growth failure is nearly universal in these infants as they near term gestation. High rates of protein loss and elevated energy expenditures uncompensated by adequate nutritional intake appear to be primary factors in producing this growth failure, perhaps producing metabolic changes that prioritize survival over growth. The goal of the present proposal is to test the overall hypothesis that nutritional inadequacies of the extrauterine environment induce adaptive responses in protein metabolism, energy expenditure, insulin sensitivity, and endothelial function in ELBW infants which persist throughout infancy. Studies will be performed in ELBW and normal control infants at term gestation, 4 and 18 months of age. The following specific aims will be pursued: 1. To assess protein kinetics and protein catabolism during enteral feeding and in response to increased protein intake in ELBW infants throughout infancy. 2. To determine the rate of total energy expenditure, resting energy expenditure, and energy of activity in ELBW infants throughout infancy. 3. To examine insulin sensitivity in ELBW infants throughout infancy. 4. To evaluate endothelial function in ELBW infants throughout infancy. These studies may form the basis for improved clinical and nutritional strategies for these infants, as well as a future opportunity to more thoroughly explore the potential mechanisms underlying these adaptations.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。尽管存活率不断提高，早产极低出生体重（ELBW）婴儿的生长结果仍然非常差。由于这些婴儿临近足月妊娠，生长障碍几乎是普遍现象。蛋白质损失率高，能量消耗增加，而没有通过充足的营养摄入来补偿，这似乎是导致生长失败的主要因素，也许会产生代谢变化，使生存优先于生长。本提案的目的是检验总体假设，即宫外环境的营养不足会引起 ELBW 婴儿蛋白质代谢、能量消耗、胰岛素敏感性和内皮功能的适应性反应，这种反应在整个婴儿期持续存在。研究将在足月妊娠、4 个月和 18 个月的 ELBW 和正常对照婴儿中进行。将追求以下具体目标： 1. 评估肠内喂养期间的蛋白质动力学和蛋白质分解代谢以及对 ELBW 婴儿整个婴儿期蛋白质摄入量增加的反应。 2. 确定 ELBW 婴儿整个婴儿期的总能量消耗率、静息能量消耗率和活动能量率。 3. 检查ELBW婴儿整个婴儿期的胰岛素敏感性。 4. 评估 ELBW 婴儿整个婴儿期的内皮功能。这些研究可能为改善这些婴儿的临床和营养策略奠定基础，并为未来更彻底地探索这些适应的潜在机制提供机会。