METABOLIC CONSEQUENCES OF GROWTH FAILURE IN EXTREMELY LOW BIRTH WEIGHT INFANTS

极低出生体重婴儿生长障碍的代谢后果

• 批准号: 7379175
• 负责人: Scott C. Denne
• 金额: $ 4.35万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379175
• 关键词: METABOLIC; CONSEQUENCES; GROWTH; FAILURE; EXTREMELY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite continually improving survival rates, growth outcomes for premature extremely low birth weight (ELBW) infants remains exceptionally poor. Growth failure is nearly universal in these infants as they near term gestation. High rates of protein loss and elevated energy expenditures uncompensated by adequate nutritional intake appear to be primary factors in producing this growth failure, perhaps producing metabolic changes that prioritize survival over growth. The goal of the present proposal is to test the overall hypothesis that nutritional inadequacies of the extrauterine environment induce adaptive responses in protein metabolism, energy expenditure, insulin sensitivity, and endothelial function in ELBW infants which persist throughout infancy. Studies will be performed in ELBW and normal control infants at term gestation, 4 and 18 months of age. The following specific aims will be pursued: 1. To assess protein kinetics and protein catabolism during enteral feeding and in response to increased protein intake in ELBW infants throughout infancy. 2. To determine the rate of total energy expenditure, resting energy expenditure, and energy of activity in ELBW infants throughout infancy. 3. To examine insulin sensitivity in ELBW infants throughout infancy. 4. To evaluate endothelial function in ELBW infants throughout infancy. These studies may form the basis for improved clinical and nutritional strategies for these infants, as well as a future opportunity to more thoroughly explore the potential mechanisms underlying these adaptations.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。尽管不断提高生存率，但早产（ELBW）婴儿的增长结果仍然异常差。在这些婴儿中，生长失败几乎是普遍的，因为它们的近期妊娠。蛋白质流失的高率和足够的营养摄入量无偿的能量消耗率高似乎是产生这种生长失败的主要因素，也许会产生代谢变化，使生存优先级优先于生长。本提案的目的是检验总体假设，即外泌氨酸外环境的营养不足会诱导蛋白质代谢，能量消耗，胰岛素敏感性和内皮功能的蛋白质代谢反应，而在整个婴儿期间持续存在。在期妊娠4个月和18个月大的期限内，将在ELBW和正常对照婴儿中进行研究。将追求以下具体目标：1。评估肠内喂养过程中蛋白质动力学和蛋白质分解代谢，并响应在整个婴儿期ELBW婴儿中蛋白质摄入量的增加。 2。确定整个婴儿期ELBW婴儿的总能量消耗，静息能量消耗和活动能量的速度。 3。检查整个婴儿期ELBW婴儿的胰岛素敏感性。 4。评估在整个婴儿期ELBW婴儿中的内皮功能。这些研究可能是改善这些婴儿临床和营养策略的基础，以及未来的机会，以更彻底地探索这些适应性的潜在机制。