WNPRC AGING COLONY RESOURCE

WNPRC 老化群体资源

• 批准号: 8173101
• 负责人: RICKI J COLMAN
• 金额: $ 23.27万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173101
• 关键词: 20 year old; Age-Years; Aging; Animals; Area; Body Composition; Bone Density; Caloric Restriction; Cognitive; Communication; Communities; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Dyslipidemias; Eating; Functional disorder; Funding; Grant; Health; Immunology; Individual; Institutes; Institution; Journals; Knowledge; Macaca mulatta; Measurement; Metabolic; Monitor; Motor Skills; Neuroendocrinology; Ovarian; Peer Review; Personal Satisfaction; Physical activity; Population; Primates; Protocols documentation; Publications; Reporting; Reproduction; Research; Research Personnel; Resource Allocation; Resources; Services; Source; Stem cells; Training; United States National Institutes of Health; Wisconsin; aged; glucose metabolism; journal article; medical attention; meetings; normal aging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To maintain and develop a specialized resource for studies related to aging. Allocation of Resource Access: The WNPRC has approximately 108 rhesus monkeys over 20 years of age. Support is provided in part by the National Institute of Aging to maintain these animals for studies relating to normal aging. During FY2009-2010, approximately 15 investigators used these animals in studies related to neuroendocrinology, calorie restriction, glucose metabolism, dyslipidemia, ovarian dysfunction, bone mineral density, osteoarthritis, immunology, stem cells, and reproduction. No request has been denied. Dissemination: Knowledge is disseminated to the scientific community via publications in peer reviewed journals and scientific meeting attendance. The Wisconsin National Primate Research Center also holds quarterly research retreats to create increased communication between the various service and resource units. Progress: During the current reporting year, approximately 15 investigators have utilized animals from the aging colony. We continue to monitor the health and well-being of all animals in the colony and evaluate aging individuals from the general colony to evaluate their appropriateness for inclusion in the aging colony. Highlights: The animals in Aged Rhesus Monkey Resource continue to receive excellent medical attention. Within the population, there is currently one very old (34 years of age) individual. Challenges: The major challenge associated with this resource is maintaining a healthy colony of an appropriate size to meet scientific need. Concerns: None. Training: Training is available on established protocols for food intake measurement, body composition assessment, physical activity monitoring, cognitive and motor skills assessment, and metabolic assessments. Training in all of these areas was carried out during the past year. Publications note: Aging Resource support is involved in numerous journal articles that depend in part or in full on WNPRC resources.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目标：维护和开发与衰老相关的研究的专门资源。 资源访问的分配： WNPRC 约有 108 只 20 岁以上的恒河猴。国家衰老研究所提供部分支持，以维持这些动物进行与正常衰老相关的研究。 2009-2010财年期间，大约15名研究人员使用这些动物进行与神经内分泌学、热量限制、葡萄糖代谢、血脂异常、卵巢功能障碍、骨矿物质密度、骨关节炎、免疫学、干细胞和生殖相关的研究。没有任何请求被拒绝。 传播： 知识通过同行评审期刊上的出版物和出席科学会议向科学界传播。威斯康星国家灵长类动物研究中心还每季度举办一次研究静修活动，以加强各个服务和资源单位之间的沟通。 进步： 在本报告年度，大约 15 名研究人员利用了来自老化群体的动物。 我们继续监测群体中所有动物的健康和福祉，并评估一般群体中的老龄个体，以评估它们是否适合纳入老龄群体。 亮点： 老年恒河猴资源中心的动物继续受到良好的医疗护理。人口中目前有一名老人（34 岁）。 挑战： 与该资源相关的主要挑战是维持适当规模的健康群体以满足科学需求。 担忧： 没有任何。 训练： 提供有关食物摄入测量、身体成分评估、身体活动监测、认知和运动技能评估以及代谢评估的既定方案的培训。 去年，我们在所有这些领域开展了培训。 出版物说明：许多期刊文章都涉及老龄化资源支持，这些文章部分或全部依赖于 WNPRC 资源。