A TRANSLATIONAL MODEL OF HEALTHY SOCIOEMOTIONAL AGING

健康社会情感老龄化的转化模型

基本信息

批准号：
9751681
负责人：
Eliza Bliss-Moreau
金额：
$ 19.3万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9751681
关键词：
12 year old 20 year old Adult Affect Affective Age Age-Years Aging Animal Behavior Animal Model Animals Anxiety Attention Autonomic nervous system Behavior Biological Biological Markers Biological Process Cognitive aging Complex Data Deterioration Development Elderly Electrocardiogram Emotional Eye Face Foundations Funding Future Goals Health Health Promotion Human Intervention Investigation Investments Laboratories Life Longitudinal Studies Macaca Macaca mulatta Mathematics Memory Modeling Monkeys Neuroanatomy Pattern Peripheral Personal Satisfaction Physiology Procedures Process Psychopathology Reporting Research Resources Sinus Arrhythmia Social Behavior Social Environment Social Interaction Stimulus Stress System Testing United States United States National Institutes of Health Uterus Visual attention Work age related aged aging population attentional bias behavior observation cohort effective intervention effective therapy electric impedance emotional experience experience experimental study healthy aging human model indexing innovation memory process middle age nonhuman primate predictive marker psychologic respiratory response social translational model young adult

项目摘要

Project Summary By 2060, there will be at least 98 million older adults (65 years of age or older) living in the United States (Colby & Ortman, 2014), underscoring the urgency to understand the biological processes that drive healthy, “successful” aging. While aging is accompanied by a host of negative changes (e.g., deterioration of memory), paradoxically, existing data demonstrate that social and emotional life actually get better with age. Older adults report more positive social experiences, more positive and/or less negative emotional experiences, and have biased attention towards positive and away from negative stimuli (e.g., Birditt et al., 2005; 2009; Luong et al., 2011; Gross et al., 1997; Carstensen et al., 2011; Isaacowitz et al., 2006a,b; Isaacowitz et al., 2008; Isaacowitz, 2012; Mather & Carstensen, 2003). This phenomenon is known as the “positivity effect” (Mather & Carstensen, 2005; Carstensen & Mikels, 2005). The goal of the proposed research is to take the first step in understanding the biological mechanisms that generate this “positivity effect” by establishing an animal model of healthy human socioemotional aging with the understanding that we must understand health to treat those who are not healthy. To that end, a suite of tests homologous to those used with humans will be used to evaluate socioemotional processes in rhesus macaques, and the translational relevance of those tests will be determined on a task-by-task basis. The proposed work will evaluate the social behavior of the animals, visual attention to positive and negative stimuli, and features of emotional responding associated with activity in the autonomic nervous system. The goal of the proposed research – to establish rhesus monkeys as a model for healthy socioemotional aging in humans – serves the long-term goal of understanding the biological mechanisms that support healthy socioemotional aging, which in turn will enable development of effective treatments and interventions to promote health and well-being in our aging population.

项目概要到 2060 年，将至少有 9800 万老年人（65 岁或以上）居住在美国（Colby & Ortman，2014），强调了了解推动健康的生物过程的紧迫性， “成功的”衰老虽然衰老伴随着许多负面变化（例如记忆力衰退），矛盾的是，现有数据表明，随着年龄的增长，社交和情感生活实际上会变得更好。报告更积极的社交经历、更积极和/或更少消极的情绪体验，并且有偏向于正面刺激而远离负面刺激（例如 Birditt 等人，2005 年；2009 年；Luong 等人， 2011；Carstensen 等人，2011；Isaacowitz 等人，2008； 2012；Mather & Carstensen，2003）。 2005；Carstensen & Mikels，2005）本研究的目标是迈出理解的第一步。通过建立健康的动物模型来产生这种“积极效应”的生物学机制人类社会情感衰老，我们必须了解健康才能治疗那些不健康的人为此，将使用一套与人类相同的测试来评估。恒河猴的社会情感过程，以及这些测试的翻译相关性将是拟议的工作将评估动物的社会行为、视觉行为。对积极和消极刺激的关注，以及与活动相关的情绪反应特征拟议研究的目标是建立恒河猴作为模型。人类健康的社会情感衰老——服务于理解生物学的长期目标支持健康的社会情感老龄化的机制，这反过来又将促进有效性的发展促进老龄化人口健康和福祉的治疗和干预措施。