Cognitive, socioaffective, and neural development following fetal Zika virus infection

胎儿寨卡病毒感染后的认知、社会情感和神经发育

基本信息

批准号：
10404877
负责人：
Eliza Bliss-Moreau
金额：
$ 7.65万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-19 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10404877
关键词：
Address Affective Age Age-Months Animals Area Astrocytes Brain Brain region Cell Nucleus Child Cognition Cognitive Control Animal Data Development Developmental Delay Disorders Epidemic Erythrocytes Evaluation Exposure to Face Fetal Development Fetus Functional disorder Funding Head Health Homeostasis Human Human Pathology Immunohistochemistry Insula of Reil Lateral Geniculate Body Literature Macaca Macaca mulatta Magnetic Resonance Imaging Maps Measures Microcephaly Microglia Modeling Motor Motor Skills Neuraxis Neurons Oranges Outcome Pathology Pattern Personal Satisfaction Primates Procedures Process Property Psychopathology Research Research Project Grants Rest Sampling Sensorimotor functions Sensory Stimulus Stream Testing Time Tissue Harvesting Tissues Toddler Training Training Support Viremia Virus Diseases Vision Visual Visual Pathways Work ZIKA ZIKV infection Zika Virus area striata base behavior influence behavior measurement cohort cranium design doctoral student effective intervention effective therapy experience experimental study fetal in utero motor control neural network neurodevelopment neuroimaging nonhuman primate novel parent grant prospective relating to nervous system response sensory mechanism sensory stimulus somatosensory visual processing

项目摘要

Project Summary At its most extreme, fetal Zika virus infection causes microcephaly – the significant shrinking of the fetal brain and skull. Accumulating evidence suggests that microcephaly is just one possible outcome of fetal Zika virus infection, however, and that babies born with normal sized heads may have significant central nervous system pathology. The long-term consequences of this pathology are unknown, leaving open the possibility of a secondary epidemic resulting from compromised cognition and socioaffective processing that will occur as babies born during the epidemic age. The proposed work for this supplement augments the Parent Grant by carrying out evaluations of the consequences of this pathology on sensorimotor development of a cohort of nonhuman primates infected with Zika virus as fetuses and a group of procedure matched, non-infected controls. We will evaluate the extent to which maternal and fetal viremia influences behavioral and neural measures of sensorimotor function. Because macaques develop approximately four times faster than humans, we will be able to prospectively model pathology that arises – that is, we will be able to predict what pathology human babies, infected with Zika virus during the 2015-2016 epidemic, will experience as they grow up. Developmental modeling of this sort is critical for developing effective interventions and treatments to encourage healthy development and ameliorate psychopathology. Funding via this supplement will support the doctoral training of a scholar from a background that is underrepresented in, and typically excluded from, STEM.

项目概要在最极端的情况下，胎儿寨卡病毒感染会导致小头畸形——胎儿大脑显着萎缩越来越多的证据表明，小头畸形只是胎儿寨卡病毒的一种可能后果。然而，感染，并且出生时头部大小正常的婴儿可能具有重要的中枢神经系统这种病理学的长期后果尚不清楚，因此有可能发生。由于认知和社会情感处理受损而导致的继发性流行病将在以下情况发生：该补充计划的拟议工作通过以下方式增加了家长补助金。评估这种病理学对一组感觉运动发育的影响胎儿时感染寨卡病毒的非人类灵长类动物和一组程序匹配、未感染的灵长类动物我们将评估母体和胎儿病毒血症对行为和神经的影响程度。由于猕猴的发育速度大约是人类的四倍，我们将能够前瞻性地对出现的病理进行建模——也就是说，我们将能够预测什么病理 2015-2016年流行期间感染寨卡病毒的人类婴儿在成长过程中将会经历。此类发展模型对于制定有效的干预措施和治疗方法至关重要通过该补充品鼓励健康发展和改善精神病理学。对来自代表性不足且通常被排除在外的背景的学者进行博士培训干。