AMINO ACIDS, SEROTONIN AND BODY WEIGHT REGULATION

氨基酸、血清素和体重调节

• 批准号: 7606938
• 负责人: DAVID C JIMERSON
• 金额: $ 4.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606938
• 关键词: Amino Acids; Anorexia Nervosa; Anxiety; Behavioral; Body Weight; Branched-Chain Amino Acids; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Disease; Distress; Double-Blind Method; Eating; Eating Disorders; Etiology; Family; Funding; Grant; Hydroxyindoleacetic Acid; Individual; Inpatients; Institution; Intervention; Medical; Mental disorders; Moods; Neuraxis; Neurotransmitters; Outpatients; Patients; Pattern; Pharmaceutical Preparations; Placebo Control; Positron-Emission Tomography; Randomized; Recovery; Recurrence; Refractory; Regulation; Relapse; Research; Research Personnel; Residual state; Resources; Serotonin; Shapes; Source; Symptoms; Therapeutic Effect; Therapeutic Human Experimentation; Thinking; Tryptophan; United States National Institutes of Health; Weight; Woman; mortality; prevent; psychosocial; receptor function; response; restoration; serotonin receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia nervosa (AN) is a serious psychiatric disorder resulting in psychosocial distress for patients and their families, potentially severe medical consequences, and substantial long-term mortality. Occuring most commonly in young women, the disorder is frequently refractory to currently available treatments. Moreover, weight restoration achieved during extended inpatient or outpatient treatment is often followed by recurrence of eating disorder symptoms and relapse to low weight. A major emphasis in current therapeutic research in AN is exploration of new interventions to stabilize recovery and prevent relapse in patients who have achieved weight restoration. This project focuses on stabilization of recovery in AN. Although the etiology of AN is unknown, altered regulation of the neurotransmitter serotonin in the central nervous system (CNS) is thought to contribute to preoccupation with body shape and weight, dysregulated eating patterns, persistent anxiety, and frequent mood fluctuations. Abnormalities in CNS serotonin regulation have also been identified in individuals who have recovered from AN, as reflected in elevated levels of the serotonin metabolite 5-HIAA in cerebrospinal fluid, alterations in serotonin receptor function in PET imaging studies and altered behavioral responses following administration of serotonin-active drugs. This project uses a randomized, placebo-controlled, double-blind crossover design to assess the potential therapeutic effects ofa mixture of branched-chain amino acids in individuals who have recovered from AN. It is hypothesized this intervention, by decreasing serotonin synthesis through lowered CNS tryptophan levels, will diminish residual eating disorder symptoms.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 神经性厌食症（AN）是一种严重的精神疾病，导致患者及其家人的社会心理困扰，潜在的严重医疗后果以及实质性的长期死亡率。 这种疾病最常见于年轻女性，经常对当前可用的治疗难治性。 此外，在延长的住院或门诊治疗期间实现的体重恢复通常是饮食失调症状的复发，并复发到低体重。 当前治疗研究的主要重点是探索新干预措施，以稳定恢复并防止恢复体重恢复的患者复发。 该项目着重于An中的恢复。 尽管AN的病因尚不清楚，但中枢神经系统（CNS）中神经递质5-羟色胺的调节被认为有助于对身体形状和体重，失调的饮食模式，持续性焦虑和频繁的情绪波动的关注。 在从AN中恢复的个体中也发现了CNS 5-羟色胺调节的异常，这反映在脑脊液中5-羟色胺代谢产物5-HIAA的水平升高，在PET成像研究中的血清素受体受体功能的改变，并改变了血清素蛋白的行为反应。活性药物。 该项目使用随机的，安慰剂对照的双盲跨界设计来评估从AN恢复的个体中分支链氨基酸混合物的潜在治疗作用。 通过降低CNS色氨酸水平降低5-羟色胺合成，可以减少残留饮食失调症症状，从而假设这种干预措施。