Symptoms, Serotonin and Amino Acids in Anorexia Nervosa

神经性厌食症的症状、血清素和氨基酸

基本信息

批准号：
7229951
负责人：
DAVID C JIMERSON
金额：
$ 17.66万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-12-09 至 2009-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7229951
关键词：
Adverse effects Amino Acids Anorexia Nervosa Anxiety Applications Grants Aromatic Amino Acids Behavioral Body Weight Body Weight decreased Body mass index Branched-Chain Amino Acids Catecholamines Cerebrospinal Fluid Characteristics Clinical Clinical Chemistry Clinical Research Clinical Trials Clinical effectiveness Communities Condition Crossover Design Daily Data Disease Distress Double-Blind Method Eating Eating Disorders Effectiveness of Interventions Energy Intake Etiology Family Funding Health Hydroxyindoleacetic Acid Individual Inpatients Intervention Israel Laboratories Medical Medical center Mental disorders Monitor Moods Neuraxis Neurotransmitters Neutral Amino Acids Outcome Outcome Measure Outpatients Pathway interactions Patients Pattern Personal Satisfaction Pharmaceutical Preparations Phase Phenylalanine Placebo Control Placebos Plasma Positron-Emission Tomography Public Health Randomized Rate Recording of previous events Recovery Recruitment Activity Recurrence Refractory Regulation Relapse Research Personnel Residual state Risk Screening procedure Serotonin Shapes Symptoms Test Result Testing Therapeutic Effect Therapeutic Human Experimentation Thinking Tryptophan Tyrosine Visit Week Weight Woman base day design disorder later incidence prevention follow-up mortality neurochemistry prevent programs psychobiologic psychosocial receptor function response restoration serotonin receptor trait treatment program

项目摘要

DESCRIPTION (provided by applicant): Project Summary: Anorexia nervosa (AN) is a serious psychiatric disorder resulting in psychosocial distress for patients and their families, potentially severe medical consequences, and substantial long-term mortality. Occurring most commonly in young women, the disorder is frequently refractory to currently available treatments. Moreover, weight restoration achieved during extended inpatient or outpatient treatment is often followed by recurrence of eating disorder symptoms and relapse to low weight. A major emphasis in current therapeutic research in AN is exploration of new interventions to stabilize recovery and prevent relapse in patients who have achieved weight restoration. This exploratory grant application focuses on stabilization of recovery in AN. Although the etiology of AN is unknown, altered regulation of the neurotransmitter serotonin in the central nervous system (CNS) is thought to contribute to preoccupation with body shape and weight, dysregulated eating patterns, persistent anxiety, and frequent mood fluctuations. Abnormalities in CNS serotonin regulation have also been identified in individuals who have recovered from AN, as reflected in elevated levels of the serotonin metabolite 5-HIAA in cerebrospinal fluid, alterations in serotonin receptor function in PET imaging studies, and altered behavioral responses following administration of serotonin-active drugs. This project uses a randomized, placebo-controlled, double-blind crossover design to assess the potential therapeutic effects of a mixture of branched-chain amino acids in individuals who have recovered from AN. It is hypothesized this intervention, by decreasing serotonin synthesis through lowered CNS tryptophan levels, will diminish residual eating disorder symptoms. If the behavioral outcomes are positive and the amino acid mixture is well tolerated, results of this exploratory study will provide the basis for designing a larger controlled trial to test the effectiveness of this intervention in relapse prevention in the treatment of AN. Relevance to Public Health: Anorexia nervosa is a serious disorder involving abnormal eating patterns, severe weight loss and related psychiatric and medical problems. Following recovery from anorexia nervosa, relapse to low weight is a frequent problem. This exploratory study will assess whether abnormal regulation of the naturally occurring neurochemical serotonin may contribute to this important public health problem.

描述（由申请人提供）：项目摘要：神经性厌食症 (AN) 是一种严重的精神疾病，会给患者及其家人带来社会心理困扰、潜在的严重医疗后果以及大量的长期死亡率。这种疾病最常见于年轻女性，目前可用的治疗方法通常难以治愈。此外，在长期住院或门诊治疗期间实现体重恢复后，通常会出现饮食失调症状复发并复发至低体重。当前 AN 治疗研究的一个主要重点是探索新的干预措施，以稳定体重恢复的患者的恢复并防止复发。这项探索性拨款申请的重点是稳定 AN 的恢复。尽管 AN 的病因尚不清楚，但中枢神经系统 (CNS) 中神经递质血清素调节的改变被认为导致对体形和体重的关注、饮食模式失调、持续焦虑和频繁的情绪波动。在从 AN 中恢复的个体中也发现了中枢神经系统血清素调节的异常，这反映在脑脊液中血清素代谢物 5-HIAA 水平升高、PET 成像研究中血清素受体功能的改变以及给药后行为反应的改变。血清素活性药物。该项目采用随机、安慰剂对照、双盲交叉设计来评估支链氨基酸混合物对 AN 康复者的潜在治疗效果。据推测，这种通过降低中枢神经系统色氨酸水平来减少血清素合成的干预措施将减少残留的饮食失调症状。如果行为结果是积极的并且氨基酸混合物耐受性良好，这项探索性研究的结果将为设计更大规模的对照试验提供基础，以测试这种干预措施在预防 AN 治疗中复发的有效性。与公共卫生的相关性：神经性厌食症是一种严重的疾病，涉及异常饮食模式、严重体重减轻以及相关的精神和医疗问题。神经性厌食症康复后，体重复发是一个常见问题。这项探索性研究将评估自然产生的神经化学物质血清素的异常调节是否可能导致这一重要的公共卫生问题。