Symptoms, Serotonin and Amino Acids in Anorexia Nervosa

神经性厌食症的症状、血清素和氨基酸

• 批准号: 7032806
• 负责人: DAVID C JIMERSON
• 金额: $ 22.3万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-09 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7032806
• 关键词: aminoacid metabolism; anorexia nervosa; behavioral /social science research tag; body composition; body weight; branched chain aminoacid; clinical research; clinical trials; diet therapy; dietary supplements; female; human subject; neuropsychology; neurotransmitter metabolism; nutrient intake activity; nutrition related tag; patient oriented research; phenylalanine; relapse /recurrence; serotonin; tryptophan; tyrosine; women' s health

DESCRIPTION (provided by applicant): Project Summary: Anorexia nervosa (AN) is a serious psychiatric disorder resulting in psychosocial distress for patients and their families, potentially severe medical consequences, and substantial long-term mortality. Occurring most commonly in young women, the disorder is frequently refractory to currently available treatments. Moreover, weight restoration achieved during extended inpatient or outpatient treatment is often followed by recurrence of eating disorder symptoms and relapse to low weight. A major emphasis in current therapeutic research in AN is exploration of new interventions to stabilize recovery and prevent relapse in patients who have achieved weight restoration. This exploratory grant application focuses on stabilization of recovery in AN. Although the etiology of AN is unknown, altered regulation of the neurotransmitter serotonin in the central nervous system (CNS) is thought to contribute to preoccupation with body shape and weight, dysregulated eating patterns, persistent anxiety, and frequent mood fluctuations. Abnormalities in CNS serotonin regulation have also been identified in individuals who have recovered from AN, as reflected in elevated levels of the serotonin metabolite 5-HIAA in cerebrospinal fluid, alterations in serotonin receptor function in PET imaging studies, and altered behavioral responses following administration of serotonin-active drugs. This project uses a randomized, placebo-controlled, double-blind crossover design to assess the potential therapeutic effects of a mixture of branched-chain amino acids in individuals who have recovered from AN. It is hypothesized this intervention, by decreasing serotonin synthesis through lowered CNS tryptophan levels, will diminish residual eating disorder symptoms. If the behavioral outcomes are positive and the amino acid mixture is well tolerated, results of this exploratory study will provide the basis for designing a larger controlled trial to test the effectiveness of this intervention in relapse prevention in the treatment of AN. Relevance to Public Health: Anorexia nervosa is a serious disorder involving abnormal eating patterns, severe weight loss and related psychiatric and medical problems. Following recovery from anorexia nervosa, relapse to low weight is a frequent problem. This exploratory study will assess whether abnormal regulation of the naturally occurring neurochemical serotonin may contribute to this important public health problem.

描述（由申请人提供）：项目摘要：神经性厌食症（AN）是一种严重的精神疾病，导致患者及其家人的社会心理困扰，潜在的严重医疗后果以及实质性的长期死亡。这种疾病最常见于年轻女性，通常对当前可用的治疗难治性。此外，在延长的住院或门诊治疗期间实现的体重恢复通常是饮食失调症状的复发，并复发到低体重。当前治疗研究的主要重点是探索新干预措施，以稳定恢复并防止恢复体重恢复的患者复发。该探索性赠款申请的重点是稳定An。尽管AN的病因尚不清楚，但中枢神经系统（CNS）中神经递质5-羟色胺的调节被认为有助于对身体形状和体重，失调的饮食模式，持续性焦虑和频繁的情绪波动的关注。在从AN中恢复的个体中也发现了CNS 5-羟色胺调节的异常，这反映在脑脊液中5-羟色胺代谢产物5-HIAA水平的升高中，PET成像研究中5-羟色胺受体功能的改变，以及在血清素活性药物施用后的行为反应中改变了行为反应。该项目使用随机的，安慰剂对照的双盲跨界设计来评估从AN恢复的个体中分支链氨基酸混合物的潜在治疗作用。通过降低CNS色氨酸水平降低5-羟色胺合成，可以减少残留饮食失调症症状，从而假设这种干预措施。如果行为结果是阳性的，并且氨基酸混合物的耐受性良好，则该探索性研究的结果将为设计较大的对照试验提供基础，以测试该干预措施在治疗AN治疗时预防复发的有效性。与公共卫生有关：神经性厌食症是一种严重的疾病，涉及异常的饮食模式，严重的体重减轻以及相关的精神病和医学问题。从神经性厌食症中恢复后，复发到低体重是一个常见问题。这项探索性研究将评估对天然神经化学5-羟色胺的异常调节可能导致这一重要的公共卫生问题。