CHANGES IN PLASMA CONCENTRATIONS OF SUGARS AND SUGAR ALCOHOLS AFTER MILK FEEDING

喂奶后血浆中糖和糖醇浓度的变化

• 批准号: 7605134
• 负责人: FREDERICK C BATTAGLIA
• 金额: $ 5.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605134
• 关键词: Blood flow; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Energy Intake; Enrollment; Erythritol; Fetal Growth Retardation; Funding; Gestational Diabetes; Glucose; Glycerol; Grant; Hepatic; High Pressure Liquid Chromatography; Human Milk; Infant; Inositol; Institution; Intake; Mannose; Measurement; Milk; Mothers; Newborn Infant; Nutrient; Plasma; Pregnancy; Research; Research Personnel; Resources; Risk; Source; Sugar Alcohols; Umbilical Blood; United States National Institutes of Health; feeding; fetal; sugar; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study in feeding newborn infants will examine whether some of the sugars and sugar alcohols in breast milk and formula show evidence of a postprandial increase in concentration. After a single milk feeding, concentrations of glucose, inositol, glycerol, erythritol, sorbital and mannose will be examined over 90 minutes following the feeding. Only infants taking in full caloric intake by milk feedings will be enrolled in the studies. The intake of each sugar and sugar alcohol will be calculated from the volume of feed and the concentrations of the sugars and alcohols in the milk used for the feeding. HPLC will be used for the carbohydrate measurements. It is anticipated that the magnitude of the postprandial peak for any single carbohydrate will be a function of the volume of the feeding and the duration of the feeding. The study will also compare postprandial concentrations of the sugars and sugar alcohols in a group of healthy, term infants to a group of "high risk" infants who are born to mothers whose pregnancies were complicated by either pre-existing or gestational diabetes (IDM), or intrauterine growth restriction (IUGR). Umbilical blood flow has been demonstrated to be significantly reduced in IUGR pregnancies which, in turn, reduce fetal hepatic blood flow. Therefore, the hepatic uptake of nutrients after a feeding may be significantly compromised in these high risk infants.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项针对新生婴儿的研究将检查母乳和配方奶中的某些糖和糖醇是否显示出餐后浓度增加的证据。喂养单一牛奶后，将在喂养后90分钟内检查葡萄糖，肌醇，甘油，嗜硫醇，s虫和甘露糖的浓度。研究只有牛奶喂养的全部热量摄入量的婴儿才会参加研究。每种糖和糖酒精的摄入量将根据饲料的量以及用于进食的牛奶中的糖和醇的浓度计算。 HPLC将用于碳水化合物测量。 预计任何单个碳水化合物的餐后峰的幅度将是进食体积和进食持续时间的函数。 该研究还将比较一群健康的，期限婴儿的糖和糖醇的餐后浓度与一组“高风险”婴儿出生于母亲出生的婴儿，他们的母亲因妊娠或妊娠糖尿病（IDM）（IDM）或肠内生长限制（IUGR）使他们的怀孕复杂化。 已经证明，脐带血流量已在IUGR妊娠中显着降低，这反过来降低了胎儿的肝血流。 因此，在这些高风险婴儿中，喂养后的肝摄取可能会受到显着损害。