ECOG-ACRIN Network Group Operations Center

ECOG-ACRIN 网络集团运营中心

基本信息

批准号：
9903239
负责人：
Peter J ODwyer
金额：
$ 807.88万
依托单位：
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-29 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9903239
关键词：
Adolescent and Young Adult Adult Affect American College of Radiology Imaging Network Automobile Driving Bioinformatics Biological Biological Assay Biological Markers Biometry Cancer Biology Cancer Center Cancer Patient Cancer Research Network Cancer Therapy Evaluation Program Caring Center for Translational Science Activities Clinical Markers Clinical Research Clinical Trials Clinical Trials Network Collaborations Communities Community Clinical Oncology Program Community Practice Complex Dana-Farber Cancer Institute Data Data Analyses Databases Development Diagnostic Imaging Discipline Disease Early Diagnosis Eastern Cooperative Oncology Group Effectiveness Environment Evolution Fostering Foundations Funding Future Goals Image Immunologics Immunology Infrastructure Institutes International Intervention Investigational Therapies Laboratories Lead Leadership Life Malignant Neoplasms Mentorship Modeling Monitor National Clinical Trials Network Oncology Outcomes Research Participant Patient Outcomes Assessments Patient Participation Patients Phase II Clinical Trials Phase III Clinical Trials Pilot Projects Population Positioning Attribute Prevalence Public Health Reporting Research Research Personnel Resources Risk Science Scientist Site Specialized Program of Research Excellence System Therapeutic Tissue imaging Translating Universities advanced disease advocacy organizations anticancer research base biobank biomarker-driven cancer clinical trial cancer therapy cancer type care outcomes career development comparative effectiveness data management data warehouse experience imaging study improved improved outcome innovation member molecular imaging multidisciplinary multimodality next generation novel operation programs quantitative imaging scientific organization screening standard of care treatment effect

项目摘要

Overall: Publicly-funded cancer clinical trials continue to establish new standards of care and improve outcomes for cancer patients. ECOG-ACRIN (EA) has instituted an organizational matrix based on the integration of biological and imaging studies with clinical trials of novel anti-cancer therapies to conduct cutting-edge clinical research and promote scientific discovery. We have incorporated expertise in imaging, cancer biology and therapy within our scientific organization, working closely with the biostatistics and data management centers at the Dana Farber Cancer Institute and Brown University, to propose a research plan that recognizes the importance of biomarkers to bring precisely targeted clinical trials to broad populations of cancer patients. The EA biorepositories, image databases, immunological laboratories, and associated translational science centers will bring together the correlative science studies that relate cancer biology to clinical markers of treatment effect in a data-rich environment. EA embraces the goals and spirit of the NCTN to conduct science-driven clinical trials to improve the lives of adults with cancer. EA clinical trials are implemented through an efficient operational infrastructure that enables access to cutting-edge treatments across the US from large cancer centers to community practices and assures accrual to complex trials in cancers of varying prevalence. Our science is driven by our membership, which includes the NCI-funded Cancer Centers, the Specialized Programs of Research Excellence (SPOREs), the ETCTN (Experimental Therapeutics Clinical Trials Network), the Quantitative Imaging Network (QIN), the NCTN Lead Academic Participating Sites (LAPS), and the National Community Oncology Research Programs (NCORP). As committed participants in the NCTN and in all aspects of CTEP-led cancer research, EA collaborates across the system to promote and advance the collective efforts of all of the groups. We make available the mentorship and opportunity needed to nourish the next generation of investigators. EA is positioned to make unique contributions to the NCTN, working to translate NCI-supported science into improved outcomes for cancer patients. This model, together with developing innovation in large data analysis, will yield high quality trials that have the potential to be practice-changing, applicable to both academic and community environments, and providing imaging and other biomarkers to identify patients who benefit most.

全面的：公共资助的癌症临床试验继续建立新的护理标准并改进癌症患者的结果。 ECOG-ACRIN (EA) 建立了一个基于关于生物和影像学研究与新型抗癌临床试验的整合疗法来进行尖端临床研究并促进科学发现。我们有将成像、癌症生物学和治疗方面的专业知识融入我们的科学组织中，与达纳法伯癌症中心的生物统计和数据管理中心密切合作研究所和布朗大学提出一项研究计划，承认其重要性生物标志物为广大癌症患者群体带来精确靶向的临床试验。这 EA 生物样本库、图像数据库、免疫实验室和相关转化科学中心将汇集与癌症生物学相关的相关科学研究在数据丰富的环境中治疗效果的临床标志。 EA 拥护目标和精神 NCTN 开展科学驱动的临床试验，以改善成人癌症患者的生活。 EA 临床试验是通过高效的运营基础设施实施的，该基础设施使从大型癌症中心到社区，都能获得美国各地的尖端治疗方法实践并确保对不同患病率的癌症进行复杂试验。我们的科学是由我们的会员推动的，其中包括 NCI 资助的癌症中心、专业卓越研究计划 (SPORE)、ETCTN（实验治疗临床 Trials Network）、定量成像网络（QIN）、NCTN 牵头学术参与站点 (LAPS) 和国家社区肿瘤学研究计划 (NCORP)。作为 NCTN 和 CTEP 主导的癌症研究各个方面的坚定参与者，EA 在整个系统内进行协作，以促进和推进所有团体的集体努力。我们提供培育下一代所需的指导和机会调查人员。 EA 致力于为 NCTN 做出独特贡献，致力于翻译 NCI 支持科学改善癌症患者的治疗结果。这个模型，连同开发大数据分析创新，将产生高质量的试验，有潜力改变实践，适用于学术和社区环境，并提供成像和其他生物标志物来识别最受益的患者。