ECOG-ACRIN NCORP Research Base

ECOG-ACRIN NCORP研究基地

• 批准号: 10603252
• 负责人: Peter J ODwyer
• 金额: $ 94.59万
• 依托单位: ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10603252
• 关键词: Adolescent and Young Adult; Adopted; Advocacy; Advocate; American College of Radiology Imaging Network; Area; Attention; Behavioral; Biological Markers; Biostatistical Methods; Breast Magnetic Resonance Imaging; Cancer Biology; Cancer Burden; Cancer Control; Cancer Prevention Trial; Cancer Research Network; Cancer Survivorship; Cardiotoxicity; Caring; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Clinical Oncology Program; Complex; Continuity of Patient Care; Data Science; Development; Diagnosis; Discipline; Early Diagnosis; Eastern Cooperative Oncology Group; Elderly; Ensure; Fostering; Funding; Goals; Image; Immunooncology; Influentials; Infrastructure; Institution; International; Intervention; Laboratories; Leadership; Malignant Neoplasms; Measurement; Medical; Minority; Mission; Monitor; National Cancer Institute; National Clinical Trials Network; Nursing Research; Participant; Patient Outcomes Assessments; Patients; Physicians; Population; Population Heterogeneity; Postdoctoral Fellow; Prevention; Prevention strategy; Prevention trial; Primary Prevention; Process; Provider; Quality of life; Reporting; Research; Research Design; Research Personnel; Research Support; Resources; Risk; Science; Scientist; Screening for cancer; Secondary Prevention; Sexual and Gender Minorities; Site; Symptoms; System; Therapeutic Trials; Tissue imaging; Translating; Translational Research; Underrepresented Minority; Underserved Population; Work; advanced disease; anticancer research; base; biobank; biomarker-driven; cancer care; cancer clinical trial; cancer prevention; cancer therapy; care delivery; career development; control trial; eHealth; ethnic minority; experience; financial toxicity; health equity; health related quality of life; high risk; high risk population; imaging biomarker; imaging modality; improved; individualized prevention; innovation; interest; member; minority engagement; multidisciplinary; novel; novel marker; oncology program; operation; overtreatment; personalized approach; physical symptom; precision oncology; prevent; programs; psychological symptom; racial minority; research study; rural dwellers; screening; support network; survivorship; symptom science; tissue biomarkers

Project Summary The ECOG-ACRIN Cancer Research Group (EA) is dedicated to decreasing the burden of cancer. EA is a vibrant member of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP), focused on practice-changing clinical and translational research across the cancer care continuum from prevention and early detection, through the management of advanced disease and its impact. As an NCORP Research Base, EA has engaged community providers and researchers to develop a robust research portfolio that spans Cancer Prevention, Cancer Control, and Cancer Care Delivery, aligned with the overall scientific themes of precision oncology, immuno-oncology, reducing overdiagnosis and overtreatment, and leveraging novel biomarker platforms. Cancer control trials examine and intervene on challenges associated with cancer and treatment-related symptoms and concerns. EA's portfolio of therapeutic trials yield opportunities to apply patient-reported outcomes measurement science to quantify health-related quality of life, symptoms, and domains most relevant to patients in the context of evolving treatment paradigms. Behavioral and biomarker-driven symptom interventions aim to improve quality of life and cancer survivorship. Cardiotoxicity research aims to mitigate risk through quantifying cardiotoxicity associated with treatment, identifying groups at risk, and advancing interventions to reduce risk. Prevention trials embrace the NCI's broad definition of prevention to include primary prevention, cancer screening, and secondary prevention and aim to identify high risk groups for precision prevention strategies. Cancer Care Delivery Research (CCDR) examines the complex interactions between patient, provider, and system factors that influence care, and adapts and evaluates interventions in heterogenous community oncology practices. Health equity research permeates EA science through embedding disparities-related research questions that span EA activities, adopting a broad view of underserved populations including adolescents and young adults, the elderly, racial and ethnic minorities, sexual and gender minorities and rural residents. Key collaborations with community-based oncology programs will ensure access to EA NCTN and NCORP trials in communities where patients receive their care. EA provides access to existing NCI-funded resources and a network of >10000 physicians, scientists, nurses, research associates (RAs), statisticians, biomedical information technologists, and patient advocates across approximately 600 institutions and organizations. EA has provided scientific leadership in the NCORP community through advancing rigorous, practice-changing clinical trials and translational research in cancer control, prevention and care delivery and is well poised to continue to support the NCI's mission to engage community-based diverse populations in cancer research.

项目概要 ECOG-ACRIN 癌症研究小组 (EA) 致力于减轻癌症负担。 EA 是国家临床试验网络 (NCTN) 和 NCI 社区肿瘤​​学的活跃成员 研究计划 (NCORP)，专注于改变实践的临床和转化研究 从预防和早期检测到先进的管理的癌症护理连续体 疾病及其影响。作为 NCORP 研究基地，EA 与社区提供商和 研究人员开发强大的研究组合，涵盖癌症预防、癌症控制和 癌症护理服务，与精准肿瘤学、免疫肿瘤学、 减少过度诊断和过度治疗，并利用新型生物标志物平台。癌症控制 试验检查和干预与癌症和治疗相关症状相关的挑战， 的担忧。 EA 的治疗试验组合为应用患者报告的结果提供了机会 测量科学来量化与健康相关的生活质量、症状和最相关的领域 治疗范式不断发展的背景下的患者。行为和生物标志物驱动的症状 干预措施旨在提高生活质量和癌症生存率。心脏毒性研究旨在 通过量化与治疗相关的心脏毒性、识别高危人群来降低风险，以及 推进干预措施以降低风险。预防试验遵循 NCI 对预防的广泛定义 包括一级预防、癌症筛查和二级预防，旨在识别高风险 精准预防策略小组。癌症护理服务研究 (CCDR) 检查 患者、提供者和影响护理的系统因素之间复杂的相互作用，并适应和 评估异质社区肿瘤学实践的干预措施。健康公平研究 通过嵌入跨越 EA 活动的与差异相关的研究问题，渗透到 EA 科学中， 对服务不足的人群采取广泛的看法，包括青少年、老年人、 种族和族裔少数群体、性少数群体和性别少数群体以及农村居民。主要合作伙伴 基于社区的肿瘤学计划将确保在社区中获得 EA NCTN 和 NCORP 试验 患者接受护理的地方。 EA 提供对 NCI 资助的现有资源和网络的访问 >10000 名医生、科学家、护士、研究员 (RA)、统计学家的生物医学信息 约 600 个机构和组织的技术专家和患者权益倡导者。 EA 有 通过推进严格的、改变实践的方式，在 NCORP 社区中提供科学领导 癌症控制、预防和护理服务方面的临床试验和转化研究已做好准备 继续支持 NCI 的使命，让社区多元化人群参与癌症研究 研究。