M-CPP PET SCANNING IN ALCOHOLISM: EFFECTS OF SERTRALINE

M-CPP PET 扫描在酗酒中的应用：舍曲林的影响

• 批准号: 7605275
• 负责人: MONTE Stuart BUCHSBAUM
• 金额: $ 5.11万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605275
• 关键词: Alcohol abuse; Alcoholism; Brain; Chemicals; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Measurement; Patients; Pharmaceutical Preparations; Publications; Purpose; Research; Research Personnel; Resources; Scanning; Selective Serotonin Reuptake Inhibitor; Serotonin; Sertraline; Source; Subgroup; System; United States National Institutes of Health; Work; Zoloft; problem drinker

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A significant body of preclinial and clinical work demonstrates the involvement of the serotonin system in alcoholism. Recent publication of two successful clinical trials of serotonin reuptake inhibitors (e.g. sertraline or Zoloft) holds signicicant promise for the field. Both of these studies depended upon the division of their alcoholic patients into subgroups to reveal the medications' efficacy. The purpose of this study is two-fold. First, to determine the effect of a chemical called serotonin in the brains of people with alcohol abuse problems and to see if measurements of serotonin functioning can help predict who will respond successfully to treatment. Second, to study whether the medication Sertraline, which works with the brain's serotonin system, is effective in the treatment of people with alcohol abuse problems.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 大量的临床前和临床工作证明了血清素系统与酒精中毒有关。 最近发表的两项血清素再摄取抑制剂（例如舍曲林或左洛复）成功的临床试验为该领域带来了巨大的希望。 这两项研究都依赖于将酗酒患者分为亚组来揭示药物的疗效。 这项研究的目的有两个。 首先，确定一种名为血清素的化学物质对有酗酒问题的人大脑的影响，并了解血清素功能的测量是否可以帮助预测谁会对治疗产生成功反应。 其次，研究药物舍曲林（Sertraline）与大脑的血清素系统起作用，是否能有效治疗酗酒问题的人。