LYSOSOMES IN ATHERSCLEROSIS

动脉粥样硬化中的溶酶体

• 批准号: 7605670
• 负责人: WALTER G JEROME
• 金额: $ 0.1万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605670
• 关键词: Acids; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Lysosomes; Membrane; Property; Research; Research Personnel; Resources; Source; Sterols; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesist hat "in cells with lysosomal sterol accumulation, the FC accummulation alters lysosomal membrane properties in ways that inhibit the ability of lysosomes to mainitain an acid pH".

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们假设“在具有溶酶体甾醇积累的细胞中，FC 积累以抑制溶酶体维持酸性 pH 的能力的方式改变溶酶体膜特性”。