Electrical Impedance Spectroscopy and Imaging

电阻抗光谱和成像

• 批准号: 7550197
• 负责人: ALEXANDER HARTOV
• 金额: $ 19万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7550197
• 关键词: Address; Age; Area; Biological; Biopsy; Blood; Blood Vessels; Breast; Cancer Detection; Cardiac; Caring; Clinical; Clinical Research; Collaborations; Collagen; Computer software; Data; Data Collection; Detection; Development; Diagnostic; Diagnostic Specificity; Differential Diagnosis; Disease; Disease regression; Edema; Electrodes; Epithelium; Evaluation; Excision; Extracellular Matrix; Fatty acid glycerol esters; Fibrosis; Foundations; Frequencies; Funding; Future; Goals; Growth; Histologic; Hormonal Change; Image; Image Analysis; Lesion; Liquid substance; Literature; Locally Advanced Malignant Neoplasm; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Measurement; Measures; Menstrual cycle; Modality; Monitor; Neoadjuvant Therapy; Operative Surgical Procedures; Palpable; Pathology; Patients; Performance; Play; Pliability; Positioning Attribute; Progress Reports; Property; Rate; Recruitment Activity; Research Design; Research Personnel; Resolution; Risk; Rodent Model; Role; Screening procedure; Signal Transduction; Source; Specificity; Spectrum Analysis; Statistically Significant; System; Technology; Testing; Therapeutic; Time; Tissues; Validation; Value Meaning; Variant; Water; Woman; base; breast density; cancer diagnosis; cancer therapy; cost; data acquisition; density; design; driving force; electric impedance; electrical property; image reconstruction; improved; in vivo; indexing; instrument; neoplastic; outcome forecast; pre-clinical; programs; prototype; response; size; tool; virtual

Data in the literature has consistently shown that there is not only significant inherent contrast in the electrical bioimpedance of normal and neoplastic breast tissue but also that spectroscopic response can provide important functional information. Further, efforts to develop tomographic imaging systems based on electrical impedance have matured to the point where many of its basic principles and practices are well understood. Project II, Electrical Impedance Spectroscopy and Imaging (EIS), has exploited this foundation to target identification of the most promising roles for EIS imaging in the setting of clinical breast care. During the current funding period, it has completed an ambitious effort to construct, deploy and initially evaluate an ultra-fast, multi-channel, multi-frequency imaging system capable of delivering a volumetric breast exam safely, comfortably and efficiently. The system and its prior prototypes have been used in well over 100 clinical sessions in order to (i) establish exam consistency, (ii) identify normative responses in breasts without disease, (iii) explore electrical property variations due to hormonal changes during the menstrual cycle and (iv) evaluate the detection and characterization of screening abnormalities. The driving force for Project II renewal is optimization, validation and thorough evaluation of the most recently installed EIS imaging system which is, by far, the most advanced version of the instrument that is expected to improve considerably the prior encouraging results. The specific aims for continuation include (1) data acquisition and breast interface optimization of electrode density, geometry, and registration for three-dimensional, high frequency EIS breast imaging, (2) software optimization for ultrafast frame-rates, multi-tone testing, virtual current drive along with three-dimensional high frequency image reconstruction, (3) development, validation and utilization of a probe-based measurement system suitable for studies of EIS-imaged breast tissues at the time of surgical resection, and (4) participation in clinical studies conducted through the Clinical Core which target screening abnormalities recommended for biopsy, palpable masses on clinical breast exams and locally-advanced cancers receiving neoadjuvant therapy. If successful, it is expected that these aims will generate sufficient evidence to allow convincing estimates of the potential of EIS breast imaging as an alternative for differential diagnosis and pilot data in support of a role in treatment prognosis and therapy monitoring to be made which would inform decisions on the initiation of multi-center trials with the technology in the future.

文献中的数据始终表明，不仅存在明显的固有对比度 正常和肿瘤性乳腺组织的电势不足，但光谱反应也可以 提供重要的功能信息。此外，为开发基于 电阻抗已经成熟到许多基本原理和实践都很好 理解。第二个项目，电阻抗光谱和成像（EIS）已利用了这一基础 目标鉴定在临床乳腺护理中，EIS成像最有希望的作用。 在当前的资金期间，它完成了雄心勃勃的努力，以建造，部署和最初 评估能够提供体积的超快速，多频道，多频成像系统 安全，舒适，有效地检查乳房检查。该系统及其先前的原型已在井中使用 超过100次临床会议以（i）建立考试一致性，（ii）确定在 乳房没有疾病，（iii）探索由于激素变化而导致的电特性变化 月经周期和（IV）评估筛查异常的检测和表征。驾驶 项目II更新的力量是对最近安装的优化，验证和彻底评估 EIS成像系统是迄今为止的最先进的仪器版本 改善先前令人鼓舞的结果。延续的具体目的包括（1）数据 电极密度，几何形状和注册的采集和乳房界面优化，用于三维， 高频EIS乳房成像，（2）超快框架速率的软件优化，多音调 测试，虚拟电流驱动器以及三维高频图像重建，（3） 基于探针的测量系统的开发，验证和利用适用于EIS成像的研究 手术切除时的乳腺组织，（4）参与进行的临床研究 通过临床核心，该临床核心筛查异常建议用于活检，可触及的质量 在临床乳房检查和接受新辅助治疗的局部癌症中。如果成功，那是 预计这些目标将产生足够的证据，以允许令人信服的估计值 EIS乳房成像是鉴别诊断和试点数据的替代方法，以支持治疗中的作用 预后和治疗监测将为多中心的启动提供决定 将来对技术进行试验。