Cryosurgery with Electrical Impedance Tomography

电阻抗断层扫描冷冻手术

• 批准号: 6337677
• 负责人: ALEXANDER HARTOV
• 金额: $ 9.47万
• 依托单位: HANOVER MEDICAL IMAGING PROJECT, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2001-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337677
• 关键词: biomedical equipment development; computer program /software; computer system design /evaluation; cryoscience; cryosurgery; electrical impedance; electrodes; necrosis; phantom model; tomography

Cryosurgery consists of deep-freezing tissue in situ to destroy, manipulate or change its structure. It is only recently that cryosurgery has gained popularity as a minimally invasive procedure, thanks to the advances in modern imaging systems. Its use in deep soft tissues and on superficial lesions has been extensively documented and its effectiveness well established. The remaining obstacle to its more widespread use resides in estimating the extent of the ice ball during procedures and estimating the extent of necrosis. Immediately following cryosurgery. This has resulted in a slow adoption of its use, particularly in the US. We propose to combine cryosurgery with impedance measurements to obtain an accurate assessment of the size and shape of the ice ball during cryosurgery. A custom cryoprobe will be designed which will allow impedance measurements to be made during a procedure. In addition, an existing impedance analyzer will be used under computer control to perform the measurements in real time and reconstruct the ice ball shape and size using the impedance recorded. Finally a series of experiments in tissue- mimicking phantoms will be conducted to evaluate the system's capability in gauging the size and shape of the ice ball. PROPOSED COMMERCIAL APPLICATIONS: The remaining obstacle to the more widespread use of cryosurgery resides in estimating the extent of the ice ball during deep procedures and estimating the extent of necrosis immediately following cryosurgery. This has resulted in a slow adoption of its user, particularly in the US. We proposed to combine cryosurgery with Electrical Impedance Tomography (EIT) to obtain an accurate assessment of the size and shape of the ice ball during cryosurgical procedures. Hanover Medical Imaging Project LLC hopes to develop an effective method to accurately monitor the size of cryolesions. This collaboration between Hanover Medical Imaging Project LLC and CryoFlex, Inc., a firm that manufactures and distributes cryosurgery equipment may result in a very significant competitive advantage in the marketing of their devices. The integration of EIT capabilities with their existing equipment would constitutive a unique and possible very significant improvement in the current state of the art in cryosurgery.

冷冻手术由原位冻结组织组成，以破坏，操纵或改变其结构。直到最近，由于现代成像系统的进步，冷冻手术作为一种微创手术才获得流行。它在深软组织和浅表病变中的使用已得到广泛的记录，并且已建立了良好的有效性。其剩余的障碍更广泛地使用在估计手术过程中冰球的程度和估计坏死程度。冷冻手术后立即。这导致其使用的缓慢采用，尤其是在美国。我们建议将冷冻手术与阻抗测量相结合，以准确评估冷冻手术过程中冰球的大小和形状。将设计一个自定义的冷冻探针，这将允许在过程中进行阻抗测量。此外，将在计算机控制下使用现有的阻抗分析仪实时执行测量，并使用记录的阻抗重建冰球形状和大小。最后，将进行一系列模拟幻象的实验，以评估系统在测量冰球大小和形状方面的能力。拟议的商业应用：冷冻手术更广泛地使用的剩余障碍在于估计深度程序中冰球的程度，并估算冷冻外科后立即估算坏死的程度。这导致其用户的采用缓慢，尤其是在美国。我们建议将冷冻手术与电阻抗断层扫描（EIT）相结合，以准确评估冷冻手术过程中冰球的大小和形状。 Hanover Medical Imaging Project LLC希望开发一种有效的方法来准确监测哭泣的大小。汉诺威医学成像项目有限责任公司与Cryoflex，Inc。之间的这种合作，一家生产和分发冷冻手术设备的公司可能会在其设备的营销中带来非常重要的竞争优势。 EIT功能与其现有设备的集成将在冷冻手术中的当前最新状态构成且可能非常显着改善。